Breath profiles by electronic nose correlate with systemic markers but not ozone response
Summary Background The evaluation of exhaled breath profiles by electronic nose (eNose) is considered as a promising non-invasive diagnostic tool, and the discrimination of breathprints between patients with COPD and asthma has been reported. The aim of this study was to assess, whether exhaled brea...
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Published in | Respiratory medicine Vol. 105; no. 9; pp. 1352 - 1363 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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01.09.2011
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Abstract | Summary Background The evaluation of exhaled breath profiles by electronic nose (eNose) is considered as a promising non-invasive diagnostic tool, and the discrimination of breathprints between patients with COPD and asthma has been reported. The aim of this study was to assess, whether exhaled breath profile analysis can detect the inflammatory airway response induced by ozone inhalation. Methods In a randomized double-blind, cross-over study 14 healthy ozone-responsive subjects were exposed to 250 ppb ozone and filtered room air for 3 h with intermittent exercise. Blood biomarkers, exhaled NO, exhaled CO, and breathprints (Cyranose 320® ) were assessed prior and at 3 time points up to 24 h post exposure. Induced sputum was collected at baseline and 3 h post exposure. Multivariate analysis of eNose data was performed using transformed and normalized datasets. Results Significantly increased numbers of sputum and blood neutrophils were observed after ozone, whereas the eNose signals showed no differences between exposures and no correlation with neutrophilic airway inflammation. However, independent of ozone exposure, sensor data correlated with serum SP-D levels and to a smaller extent with blood neutrophil numbers. Conclusions Exhaled breath profiles as measured by the Cyranose 320® did not reflect airway responses to ozone. This suggests that exhaled volatiles did not change with ozone challenges or that the changes were below the detection limits. Conversely, the correlation of eNose signals with blood neutrophils and serum SP-D, i.e. markers of systemic inflammation and lung permeability, suggested that the Cyranose 320® can detect volatile organic compounds of systemic origin. |
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AbstractList | Summary Background The evaluation of exhaled breath profiles by electronic nose (eNose) is considered as a promising non-invasive diagnostic tool, and the discrimination of breathprints between patients with COPD and asthma has been reported. The aim of this study was to assess, whether exhaled breath profile analysis can detect the inflammatory airway response induced by ozone inhalation. Methods In a randomized double-blind, cross-over study 14 healthy ozone-responsive subjects were exposed to 250 ppb ozone and filtered room air for 3 h with intermittent exercise. Blood biomarkers, exhaled NO, exhaled CO, and breathprints (Cyranose 320® ) were assessed prior and at 3 time points up to 24 h post exposure. Induced sputum was collected at baseline and 3 h post exposure. Multivariate analysis of eNose data was performed using transformed and normalized datasets. Results Significantly increased numbers of sputum and blood neutrophils were observed after ozone, whereas the eNose signals showed no differences between exposures and no correlation with neutrophilic airway inflammation. However, independent of ozone exposure, sensor data correlated with serum SP-D levels and to a smaller extent with blood neutrophil numbers. Conclusions Exhaled breath profiles as measured by the Cyranose 320® did not reflect airway responses to ozone. This suggests that exhaled volatiles did not change with ozone challenges or that the changes were below the detection limits. Conversely, the correlation of eNose signals with blood neutrophils and serum SP-D, i.e. markers of systemic inflammation and lung permeability, suggested that the Cyranose 320® can detect volatile organic compounds of systemic origin. The evaluation of exhaled breath profiles by electronic nose (eNose) is considered as a promising non-invasive diagnostic tool, and the discrimination of breathprints between patients with COPD and asthma has been reported. The aim of this study was to assess, whether exhaled breath profile analysis can detect the inflammatory airway response induced by ozone inhalation. In a randomized double-blind, cross-over study 14 healthy ozone-responsive subjects were exposed to 250 ppb ozone and filtered room air for 3h with intermittent exercise. Blood biomarkers, exhaled NO, exhaled CO, and breathprints (Cyranose 320(®)) were assessed prior and at 3 time points up to 24h post exposure. Induced sputum was collected at baseline and 3h post exposure. Multivariate analysis of eNose data was performed using transformed and normalized datasets. Significantly increased numbers of sputum and blood neutrophils were observed after ozone, whereas the eNose signals showed no differences between exposures and no correlation with neutrophilic airway inflammation. However, independent of ozone exposure, sensor data correlated with serum SP-D levels and to a smaller extent with blood neutrophil numbers. Exhaled breath profiles as measured by the Cyranose 320(®) did not reflect airway responses to ozone. This suggests that exhaled volatiles did not change with ozone challenges or that the changes were below the detection limits. Conversely, the correlation of eNose signals with blood neutrophils and serum SP-D, i.e. markers of systemic inflammation and lung permeability, suggested that the Cyranose 320(®) can detect volatile organic compounds of systemic origin. The evaluation of exhaled breath profiles by electronic nose (eNose) is considered as a promising non-invasive diagnostic tool, and the discrimination of breathprints between patients with COPD and asthma has been reported. The aim of this study was to assess, whether exhaled breath profile analysis can detect the inflammatory airway response induced by ozone inhalation. In a randomized double-blind, cross-over study 14 healthy ozone-responsive subjects were exposed to 250 ppb ozone and filtered room air for 3 h with intermittent exercise. Blood biomarkers, exhaled NO, exhaled CO, and breathprints (Cyranose 320 ®) were assessed prior and at 3 time points up to 24 h post exposure. Induced sputum was collected at baseline and 3 h post exposure. Multivariate analysis of eNose data was performed using transformed and normalized datasets. Significantly increased numbers of sputum and blood neutrophils were observed after ozone, whereas the eNose signals showed no differences between exposures and no correlation with neutrophilic airway inflammation. However, independent of ozone exposure, sensor data correlated with serum SP-D levels and to a smaller extent with blood neutrophil numbers. Exhaled breath profiles as measured by the Cyranose 320 ® did not reflect airway responses to ozone. This suggests that exhaled volatiles did not change with ozone challenges or that the changes were below the detection limits. Conversely, the correlation of eNose signals with blood neutrophils and serum SP-D, i.e. markers of systemic inflammation and lung permeability, suggested that the Cyranose 320 ® can detect volatile organic compounds of systemic origin. The evaluation of exhaled breath profiles by electronic nose (eNose) is considered as a promising non-invasive diagnostic tool, and the discrimination of breathprints between patients with COPD and asthma has been reported. The aim of this study was to assess, whether exhaled breath profile analysis can detect the inflammatory airway response induced by ozone inhalation. In a randomized double-blind, cross-over study 14 healthy ozone-responsive subjects were exposed to 250ppb ozone and filtered room air for 3h with intermittent exercise. Blood biomarkers, exhaled NO, exhaled CO, and breathprints (Cyranose 320® ) were assessed prior and at 3 time points up to 24h post exposure. Induced sputum was collected at baseline and 3h post exposure. Multivariate analysis of eNose data was performed using transformed and normalized datasets. Significantly increased numbers of sputum and blood neutrophils were observed after ozone, whereas the eNose signals showed no differences between exposures and no correlation with neutrophilic airway inflammation. However, independent of ozone exposure, sensor data correlated with serum SP-D levels and to a smaller extent with blood neutrophil numbers. Exhaled breath profiles as measured by the Cyranose 320® did not reflect airway responses to ozone. This suggests that exhaled volatiles did not change with ozone challenges or that the changes were below the detection limits. Conversely, the correlation of eNose signals with blood neutrophils and serum SP-D, i.e. markers of systemic inflammation and lung permeability, suggested that the Cyranose 320® can detect volatile organic compounds of systemic origin. |
Author | Holz, Olaf Krug, Norbert Müller, Meike Koch, Wolfgang Biller, Heike Windt, Horst Hohlfeld, Jens M Jörres, Rudolf A |
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Keywords | Volatile organic compounds Ozone challenge Non-invasive monitoring Electronic nose Biological marker Ozone Systemic Profile Nose Non invasive method compounds Disseminated Volatile organic Monitoring Pneumology |
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Snippet | Summary Background The evaluation of exhaled breath profiles by electronic nose (eNose) is considered as a promising non-invasive diagnostic tool, and the... The evaluation of exhaled breath profiles by electronic nose (eNose) is considered as a promising non-invasive diagnostic tool, and the discrimination of... |
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SubjectTerms | Adult Air pollution Asthma Asthma - diagnosis Biological and medical sciences Biomarkers Biomarkers - analysis Biomarkers - metabolism Biosensing Techniques - instrumentation Biosensing Techniques - methods Breath Tests - instrumentation Breath Tests - methods Cross-Over Studies Data processing Discriminant analysis Double-Blind Method Electronic nose Exhalation Female Humans Male Medical sciences Methods Multivariate Analysis Nitric oxide Nitric Oxide - analysis Nitric Oxide - metabolism Non-invasive monitoring Ozone Ozone challenge Pneumology Principal components analysis Pulmonary Disease, Chronic Obstructive - diagnosis Pulmonary/Respiratory Sputum - metabolism Studies Volatile organic compounds Volatile Organic Compounds - analysis Volatile Organic Compounds - metabolism |
Title | Breath profiles by electronic nose correlate with systemic markers but not ozone response |
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