The fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals

• Published in: Scientific reports Vol. 6; no. 1; p. 22279
• Main Authors: Lea, Richard G., Amezaga, Maria R., Loup, Benoit, Mandon-Pépin, Béatrice, Stefansdottir, Agnes, Filis, Panagiotis, Kyle, Carol, Zhang, Zulin, Allen, Ceri, Purdie, Laura, Jouneau, Luc, Cotinot, Corinne, Rhind, Stewart M., Sinclair, Kevin D., Fowler, Paul A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.03.2016; Nature Publishing Group
• Subjects: 13; 45/77; 631/136; 631/136/1455; 82; 82/51; 82/79; Agricultural practices; Animals; Anogenital; Biosolids; Chemicals; Development Biology; Environmental Pollutants - toxicity; Exposure; Female; Fertilizers; Fetus - anatomy & histology; Fetus - drug effects; Fetuses; Follicles; Gene Expression Regulation, Developmental - drug effects; Gestation; Humanities and Social Sciences; Laminin - metabolism; Life Sciences; Liver; Liver - drug effects; Liver - metabolism; Maternal Exposure; multidisciplinary; Nuclear Proteins - metabolism; Offspring; Ovarian Follicle - drug effects; Ovarian Follicle - embryology; Ovarian Follicle - metabolism; Ovaries; Ovary - drug effects; Ovary - embryology; Ovary - metabolism; Pasture; Polybrominated diphenyl ethers; Pregnancy; Protein Transport - drug effects; Proteome - metabolism; Reproductive Biology; Reproductive status; Science; Science (multidisciplinary); Sewage; Sewage - chemistry; Sewage sludge; Sheep - embryology; Sheep - genetics; Sludge; Time Factors; Transcriptome - drug effects; Transcriptome - genetics; enzyme expression; identification; primordial follicle; liver; disruption; in utero exposure; postnatal exposure; maternal smoking; sewage sludge; sheep ovary

The development of fetal ovarian follicles is a critical determinant of adult female reproductive competence. Prolonged exposure to environmental chemicals (ECs) can perturb this process with detrimental consequences for offspring. Here we report on the exposure of pregnant ewes to an environmental...