The fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals

The development of fetal ovarian follicles is a critical determinant of adult female reproductive competence. Prolonged exposure to environmental chemicals (ECs) can perturb this process with detrimental consequences for offspring. Here we report on the exposure of pregnant ewes to an environmental...

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Published inScientific reports Vol. 6; no. 1; p. 22279
Main Authors Lea, Richard G., Amezaga, Maria R., Loup, Benoit, Mandon-Pépin, Béatrice, Stefansdottir, Agnes, Filis, Panagiotis, Kyle, Carol, Zhang, Zulin, Allen, Ceri, Purdie, Laura, Jouneau, Luc, Cotinot, Corinne, Rhind, Stewart M., Sinclair, Kevin D., Fowler, Paul A.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 02.03.2016
Nature Publishing Group
Subjects
13
45/77
631/136
631/136/1455
82
82/51
82/79
Agricultural practices
Animals
Anogenital
Biosolids
Chemicals
Development Biology
Environmental Pollutants - toxicity
Exposure
Female
Fertilizers
Fetus - anatomy & histology
Fetus - drug effects
Fetuses
Follicles
Gene Expression Regulation, Developmental - drug effects
Gestation
Humanities and Social Sciences
Laminin - metabolism
Life Sciences
Liver
Liver - drug effects
Liver - metabolism
Maternal Exposure
multidisciplinary
Nuclear Proteins - metabolism
Offspring
Ovarian Follicle - drug effects
Ovarian Follicle - embryology
Ovarian Follicle - metabolism
Ovaries
Ovary - drug effects
Ovary - embryology
Ovary - metabolism
Pasture
Polybrominated diphenyl ethers
Pregnancy
Protein Transport - drug effects
Proteome - metabolism
Reproductive Biology
Reproductive status
Science
Science (multidisciplinary)
Sewage
Sewage - chemistry
Sewage sludge
Sheep - embryology
Sheep - genetics
Sludge
Time Factors
Transcriptome - drug effects
Transcriptome - genetics
enzyme expression
identification
primordial follicle
liver
disruption
in utero exposure
postnatal exposure
maternal smoking
sewage sludge
sheep ovary
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Abstract The development of fetal ovarian follicles is a critical determinant of adult female reproductive competence. Prolonged exposure to environmental chemicals (ECs) can perturb this process with detrimental consequences for offspring. Here we report on the exposure of pregnant ewes to an environmental mixture of ECs derived from pastures fertilized with sewage sludge (biosolids): a common global agricultural practice. Exposure of pregnant ewes to ECs over 80 day periods during early, mid or late gestation reduced the proportion of healthy early stage fetal follicles comprising the ovarian reserve. Mid and late gestation EC exposures had the most marked effects, disturbing maternal and fetal liver chemical profiles, masculinising fetal anogenital distance and greatly increasing the number of altered fetal ovarian genes and proteins. In conclusion, differential temporal sensitivity of the fetus and its ovaries to EC mixtures has implications for adult ovarian function following adverse exposures during pregnancy.
AbstractList The development of fetal ovarian follicles is a critical determinant of adult female reproductive competence. Prolonged exposure to environmental chemicals (ECs) can perturb this process with detrimental consequences for offspring. Here we report on the exposure of pregnant ewes to an environmental mixture of ECs derived from pastures fertilized with sewage sludge (biosolids): a common global agricultural practice. Exposure of pregnant ewes to ECs over 80 day periods during early, mid or late gestation reduced the proportion of healthy early stage fetal follicles comprising the ovarian reserve. Mid and late gestation EC exposures had the most marked effects, disturbing maternal and fetal liver chemical profiles, masculinising fetal anogenital distance and greatly increasing the number of altered fetal ovarian genes and proteins. In conclusion, differential temporal sensitivity of the fetus and its ovaries to EC mixtures has implications for adult ovarian function following adverse exposures during pregnancy.
ArticleNumber 22279
Author Kyle, Carol
Cotinot, Corinne
Loup, Benoit
Mandon-Pépin, Béatrice
Amezaga, Maria R.
Fowler, Paul A.
Stefansdottir, Agnes
Filis, Panagiotis
Purdie, Laura
Jouneau, Luc
Lea, Richard G.
Rhind, Stewart M.
Sinclair, Kevin D.
Zhang, Zulin
Allen, Ceri
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Copyright The Author(s) 2016
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Issue 1
Keywords enzyme expression
identification
primordial follicle
liver
disruption
in utero exposure
postnatal exposure
maternal smoking
sewage sludge
sheep ovary
Language English
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These authors jointly supervised this work.
Deceased.
Present address: Research and Development Office, NHS Grampian, Foresterhill, Aberdeen, AB25 2ZB, UK.
Present address: Centre for Integrative Physiology, University of Edinburgh, EH8 9XD, UK.
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Snippet The development of fetal ovarian follicles is a critical determinant of adult female reproductive competence. Prolonged exposure to environmental chemicals...
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Agricultural practices
Animals
Anogenital
Biosolids
Chemicals
Development Biology
Environmental Pollutants - toxicity
Exposure
Female
Fertilizers
Fetus - anatomy & histology
Fetus - drug effects
Fetuses
Follicles
Gene Expression Regulation, Developmental - drug effects
Gestation
Humanities and Social Sciences
Laminin - metabolism
Life Sciences
Liver
Liver - drug effects
Liver - metabolism
Maternal Exposure
multidisciplinary
Nuclear Proteins - metabolism
Offspring
Ovarian Follicle - drug effects
Ovarian Follicle - embryology
Ovarian Follicle - metabolism
Ovaries
Ovary - drug effects
Ovary - embryology
Ovary - metabolism
Pasture
Polybrominated diphenyl ethers
Pregnancy
Protein Transport - drug effects
Proteome - metabolism
Reproductive Biology
Reproductive status
Science
Science (multidisciplinary)
Sewage
Sewage - chemistry
Sewage sludge
Sheep - embryology
Sheep - genetics
Sludge
Time Factors
Transcriptome - drug effects
Transcriptome - genetics
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Title The fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals
URI https://link.springer.com/article/10.1038/srep22279
https://www.ncbi.nlm.nih.gov/pubmed/26931299
https://www.proquest.com/docview/1898704482
https://search.proquest.com/docview/1770219448
https://hal.inrae.fr/hal-02641103
https://pubmed.ncbi.nlm.nih.gov/PMC4773987
Volume 6
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