Rapid dramatic alterations to the tumor microstructure in pancreatic cancer following irreversible electroporation ablation
NanoKnife (Angiodynamics, Inc., NY, USA) or irreversible electroporation (IRE) is a newly available ablation technique to induce the formation of nanoscale pores within the cell membrane in targeted tissues. The purpose of this study was to elucidate morphological alterations following 30 min of IRE...
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| Published in | Nanomedicine (London, England) Vol. 9; no. 8; pp. 1181 - 1192 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Future Medicine Ltd
01.06.2014
Future Medicine |
| Subjects | |
| Online Access | Get full text |
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| Abstract | NanoKnife
(Angiodynamics, Inc., NY, USA) or irreversible electroporation (IRE) is a newly available ablation technique to induce the formation of nanoscale pores within the cell membrane in targeted tissues. The purpose of this study was to elucidate morphological alterations following 30 min of IRE ablation in a mouse model of pancreatic cancer.
Immunohistochemistry markers were compared with diffusion-weighted MRI apparent diffusion coefficient measurements before and after IRE ablation.
Immunohistochemistry apoptosis index measurements were significantly higher in IRE-treated tumors than in controls. Rapid tissue alterations after 30 min of IRE ablation procedures (structural and morphological alterations along with significantly elevated apoptosis markers) were consistently observed and well correlated to apparent diffusion coefficient measurements.
This imaging assay offers the potential to serve as an
biomarker for noninvasive detection of tumor response following IRE ablation.
Original submitted 2 October 2012; Revised submitted 12 March 2013 |
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| AbstractList | NanoKnife
(Angiodynamics, Inc., NY, USA) or irreversible electroporation (IRE) is a newly available ablation technique to induce the formation of nanoscale pores within the cell membrane in targeted tissues. The purpose of this study was to elucidate morphological alterations following 30 min of IRE ablation in a mouse model of pancreatic cancer.
Immunohistochemistry markers were compared with diffusion-weighted MRI apparent diffusion coefficient measurements before and after IRE ablation.
Immunohistochemistry apoptosis index measurements were significantly higher in IRE-treated tumors than in controls. Rapid tissue alterations after 30 min of IRE ablation procedures (structural and morphological alterations along with significantly elevated apoptosis markers) were consistently observed and well correlated to apparent diffusion coefficient measurements.
This imaging assay offers the potential to serve as an
biomarker for noninvasive detection of tumor response following IRE ablation.
Original submitted 2 October 2012; Revised submitted 12 March 2013 AIMNanoKnife(®) (Angiodynamics, Inc., NY, USA) or irreversible electroporation (IRE) is a newly available ablation technique to induce the formation of nanoscale pores within the cell membrane in targeted tissues. The purpose of this study was to elucidate morphological alterations following 30 min of IRE ablation in a mouse model of pancreatic cancer. MATERIALS & METHODSImmunohistochemistry markers were compared with diffusion-weighted MRI apparent diffusion coefficient measurements before and after IRE ablation. RESULTSImmunohistochemistry apoptosis index measurements were significantly higher in IRE-treated tumors than in controls. Rapid tissue alterations after 30 min of IRE ablation procedures (structural and morphological alterations along with significantly elevated apoptosis markers) were consistently observed and well correlated to apparent diffusion coefficient measurements. DISCUSSIONThis imaging assay offers the potential to serve as an in vivo biomarker for noninvasive detection of tumor response following IRE ablation. NanoKnife(®) (Angiodynamics, Inc., NY, USA) or irreversible electroporation (IRE) is a newly available ablation technique to induce the formation of nanoscale pores within the cell membrane in targeted tissues. The purpose of this study was to elucidate morphological alterations following 30 min of IRE ablation in a mouse model of pancreatic cancer. Immunohistochemistry markers were compared with diffusion-weighted MRI apparent diffusion coefficient measurements before and after IRE ablation. Immunohistochemistry apoptosis index measurements were significantly higher in IRE-treated tumors than in controls. Rapid tissue alterations after 30 min of IRE ablation procedures (structural and morphological alterations along with significantly elevated apoptosis markers) were consistently observed and well correlated to apparent diffusion coefficient measurements. This imaging assay offers the potential to serve as an in vivo biomarker for noninvasive detection of tumor response following IRE ablation. Aim: NanoKnife super( registered ) (Angiodynamics, Inc., NY, USA) or irreversible electroporation (IRE) is a newly available ablation technique to induce the formation of nanoscale pores within the cell membrane in targeted tissues. The purpose of this study was to elucidate morphological alterations following 30 min of IRE ablation in a mouse model of pancreatic cancer. Materials & methods: Immunohistochemistry markers were compared with diffusion-weighted MRI apparent diffusion coefficient measurements before and after IRE ablation. Results: Immunohistochemistry apoptosis index measurements were significantly higher in IRE-treated tumors than in controls. Rapid tissue alterations after 30 min of IRE ablation procedures (structural and morphological alterations along with significantly elevated apoptosis markers) were consistently observed and well correlated to apparent diffusion coefficient measurements. Discussion: This imaging assay offers the potential to serve as an in vivo biomarker for noninvasive detection of tumor response following IRE ablation. Original submitted 2 October 2012; Revised submitted 12 March 2013 Aim: NanoKnife® (Angiodynamics, Inc., NY, USA) or irreversible electroporation (IRE) is a newly available ablation technique to induce the formation of nanoscale pores within the cell membrane in targeted tissues. The purpose of this study was to elucidate morphological alterations following 30 min of IRE ablation in a mouse model of pancreatic cancer. Materials & methods: Immunohistochemistry markers were compared with diffusion-weighted MRI apparent diffusion coefficient measurements before and after IRE ablation. Results: Immunohistochemistry apoptosis index measurements were significantly higher in IRE-treated tumors than in controls. Rapid tissue alterations after 30 min of IRE ablation procedures (structural and morphological alterations along with significantly elevated apoptosis markers) were consistently observed and well correlated to apparent diffusion coefficient measurements. Discussion: This imaging assay offers the potential to serve as an in vivo biomarker for noninvasive detection of tumor response following IRE ablation. Original submitted 2 October 2012; Revised submitted 12 March 2013 |
| Author | Procissi, Daniel Tyler, Patrick Li, Weiguo Larson, Andrew C Zhang, Zhuoli Omary, Reed A |
| AuthorAffiliation | 3Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA 1Department of Radiology, Northwestern University, 737 N. Michigan Avenue, 16th Floor, Chicago, IL 60611, USA 2Robert H Lurie Comprehensive Cancer Center, Northwestern University, 737 N. Michigan Avenue, 16th Floor, Chicago, IL 60611, USA |
| AuthorAffiliation_xml | – name: 1Department of Radiology, Northwestern University, 737 N. Michigan Avenue, 16th Floor, Chicago, IL 60611, USA – name: 2Robert H Lurie Comprehensive Cancer Center, Northwestern University, 737 N. Michigan Avenue, 16th Floor, Chicago, IL 60611, USA – name: 3Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA – name: 3 Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA – name: 2 Robert H Lurie Comprehensive Cancer Center, Northwestern University, 737 N. Michigan Avenue, 16th Floor, Chicago, IL 60611, USA – name: 1 Department of Radiology, Northwestern University, 737 N. Michigan Avenue, 16th Floor, Chicago, IL 60611, USA |
| Author_xml | – sequence: 1 givenname: Zhuoli surname: Zhang fullname: Zhang, Zhuoli – sequence: 2 givenname: Weiguo surname: Li fullname: Li, Weiguo – sequence: 3 givenname: Daniel surname: Procissi fullname: Procissi, Daniel – sequence: 4 givenname: Patrick surname: Tyler fullname: Tyler, Patrick – sequence: 5 givenname: Reed A surname: Omary fullname: Omary, Reed A – sequence: 6 givenname: Andrew C surname: Larson fullname: Larson, Andrew C |
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| Keywords | Immunohistochemistry MRI biomarker Processing pancreatic cancer Surgery Pancreas cancer Diffusion coefficient Biological markers Irreversible electroporation Nanomedicine Pancreatic disease Cell killing Treatment efficiency NanoKnife NMR imaging Instrumentation therapy Ablation Anatomic pathology Animals therapy response Medical imagery Digestive diseases Mice Microstructure Cancer Apoptosis apoptosis irreversible electroporation |
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| Snippet | NanoKnife
(Angiodynamics, Inc., NY, USA) or irreversible electroporation (IRE) is a newly available ablation technique to induce the formation of nanoscale... NanoKnife(®) (Angiodynamics, Inc., NY, USA) or irreversible electroporation (IRE) is a newly available ablation technique to induce the formation of nanoscale... Aim: NanoKnife® (Angiodynamics, Inc., NY, USA) or irreversible electroporation (IRE) is a newly available ablation technique to induce the formation of... AIMNanoKnife(®) (Angiodynamics, Inc., NY, USA) or irreversible electroporation (IRE) is a newly available ablation technique to induce the formation of... Aim: NanoKnife super( registered ) (Angiodynamics, Inc., NY, USA) or irreversible electroporation (IRE) is a newly available ablation technique to induce the... |
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| SubjectTerms | Ablation Techniques - methods Animals apoptosis Biological and medical sciences Cell Line, Tumor Cross-disciplinary physics: materials science; rheology Electroporation - methods Exact sciences and technology Gastroenterology. Liver. Pancreas. Abdomen Humans irreversible electroporation Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Materials science Medical sciences Mice Mice, Inbred BALB C MRI biomarker Multiple tumors. Solid tumors. Tumors in childhood (general aspects) NanoKnife Nanoscale materials and structures: fabrication and characterization Pancreas - pathology Pancreas - surgery Pancreatic cancer Pancreatic Neoplasms - pathology Pancreatic Neoplasms - surgery Physics therapy response Tumors |
| Title | Rapid dramatic alterations to the tumor microstructure in pancreatic cancer following irreversible electroporation ablation |
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