Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth

• Published in: Nature communications Vol. 8; no. 1; pp. 15080 - 17
• Main Authors: Shi, Yu, Ping, Yi-Fang, Zhou, Wenchao, He, Zhi-Cheng, Chen, Cong, Bian, Bai-Shi-Jiao, Zhang, Lin, Chen, Lu, Lan, Xun, Zhang, Xian-Chao, Zhou, Kai, Liu, Qing, Long, Hua, Fu, Ti-Wei, Zhang, Xiao-Ning, Cao, Mian-Fu, Huang, Zhi, Fang, Xiaoguang, Wang, Xiuxing, Feng, Hua, Yao, Xiao-Hong, Yu, Shi-Cang, Cui, You-Hong, Zhang, Xia, Rich, Jeremy N, Bao, Shideng, Bian, Xiu-Wu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/31; 13/51; 13/89; 14/19; 14/5; 42; 631/67/1922; 631/67/327; 631/67/580; 631/67/71; Brain cancer; Humanities and Social Sciences; Infiltration; Medical prognosis; multidisciplinary; Science; Science (multidisciplinary); Signal transduction; Stem cells; Tumors; United States > US; China

Intense infiltration of tumour-associated macrophages (TAMs) facilitates malignant growth of glioblastoma (GBM), but the underlying mechanisms remain undefined. Herein, we report that TAMs secrete abundant pleiotrophin (PTN) to stimulate glioma stem cells (GSCs) through its receptor PTPRZ1 thus prom...