Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth
Intense infiltration of tumour-associated macrophages (TAMs) facilitates malignant growth of glioblastoma (GBM), but the underlying mechanisms remain undefined. Herein, we report that TAMs secrete abundant pleiotrophin (PTN) to stimulate glioma stem cells (GSCs) through its receptor PTPRZ1 thus prom...
Saved in:
| Published in | Nature communications Vol. 8; no. 1; pp. 15080 - 17 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
01.06.2017
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Intense infiltration of tumour-associated macrophages (TAMs) facilitates malignant growth of glioblastoma (GBM), but the underlying mechanisms remain undefined. Herein, we report that TAMs secrete abundant pleiotrophin (PTN) to stimulate glioma stem cells (GSCs) through its receptor PTPRZ1 thus promoting GBM malignant growth through PTN–PTPRZ1 paracrine signalling. PTN expression correlates with infiltration of CD11b
+
/CD163
+
TAMs and poor prognosis of GBM patients. Co-implantation of M2-like macrophages (MLCs) promoted GSC-driven tumour growth, but silencing PTN expression in MLCs mitigated their pro-tumorigenic activity. The PTN receptor PTPRZ1 is preferentially expressed in GSCs and also predicts GBM poor prognosis. Disrupting PTPRZ1 abrogated GSC maintenance and tumorigenic potential. Moreover, blocking the PTN–PTPRZ1 signalling by shRNA or anti-PTPRZ1 antibody potently suppressed GBM tumour growth and prolonged animal survival. Our study uncovered a critical molecular crosstalk between TAMs and GSCs through the PTN–PTPRZ1 paracrine signalling to support GBM malignant growth, indicating that targeting this signalling axis may have therapeutic potential.
Tumour-associated macrophages (TAMs) facilitate malignant growth of glioblastoma (GBM). Here, the authors show that TAMs support glioma stem cell renewal via paracrine signalling to the pleiotrophin receptor PTPRZ1 and that blocking this axis results in increased survival of tumour-bearing animals. |
|---|---|
| AbstractList | Intense infiltration of tumour-associated macrophages (TAMs) facilitates malignant growth of glioblastoma (GBM), but the underlying mechanisms remain undefined. Herein, we report that TAMs secrete abundant pleiotrophin (PTN) to stimulate glioma stem cells (GSCs) through its receptor PTPRZ1 thus promoting GBM malignant growth through PTN–PTPRZ1 paracrine signalling. PTN expression correlates with infiltration of CD11b
+
/CD163
+
TAMs and poor prognosis of GBM patients. Co-implantation of M2-like macrophages (MLCs) promoted GSC-driven tumour growth, but silencing PTN expression in MLCs mitigated their pro-tumorigenic activity. The PTN receptor PTPRZ1 is preferentially expressed in GSCs and also predicts GBM poor prognosis. Disrupting PTPRZ1 abrogated GSC maintenance and tumorigenic potential. Moreover, blocking the PTN–PTPRZ1 signalling by shRNA or anti-PTPRZ1 antibody potently suppressed GBM tumour growth and prolonged animal survival. Our study uncovered a critical molecular crosstalk between TAMs and GSCs through the PTN–PTPRZ1 paracrine signalling to support GBM malignant growth, indicating that targeting this signalling axis may have therapeutic potential.
Tumour-associated macrophages (TAMs) facilitate malignant growth of glioblastoma (GBM). Here, the authors show that TAMs support glioma stem cell renewal via paracrine signalling to the pleiotrophin receptor PTPRZ1 and that blocking this axis results in increased survival of tumour-bearing animals. Intense infiltration of tumour-associated macrophages (TAMs) facilitates malignant growth of glioblastoma (GBM), but the underlying mechanisms remain undefined. Herein, we report that TAMs secrete abundant pleiotrophin (PTN) to stimulate glioma stem cells (GSCs) through its receptor PTPRZ1 thus promoting GBM malignant growth through PTN-PTPRZ1 paracrine signalling. PTN expression correlates with infiltration of CD11b+ /CD163+ TAMs and poor prognosis of GBM patients. Co-implantation of M2-like macrophages (MLCs) promoted GSC-driven tumour growth, but silencing PTN expression in MLCs mitigated their pro-tumorigenic activity. The PTN receptor PTPRZ1 is preferentially expressed in GSCs and also predicts GBM poor prognosis. Disrupting PTPRZ1 abrogated GSC maintenance and tumorigenic potential. Moreover, blocking the PTN-PTPRZ1 signalling by shRNA or anti-PTPRZ1 antibody potently suppressed GBM tumour growth and prolonged animal survival. Our study uncovered a critical molecular crosstalk between TAMs and GSCs through the PTN-PTPRZ1 paracrine signalling to support GBM malignant growth, indicating that targeting this signalling axis may have therapeutic potential. Intense infiltration of tumour-associated macrophages (TAMs) facilitates malignant growth of glioblastoma (GBM), but the underlying mechanisms remain undefined. Herein, we report that TAMs secrete abundant pleiotrophin (PTN) to stimulate glioma stem cells (GSCs) through its receptor PTPRZ1 thus promoting GBM malignant growth through PTN-PTPRZ1 paracrine signalling. PTN expression correlates with infiltration of CD11b /CD163 TAMs and poor prognosis of GBM patients. Co-implantation of M2-like macrophages (MLCs) promoted GSC-driven tumour growth, but silencing PTN expression in MLCs mitigated their pro-tumorigenic activity. The PTN receptor PTPRZ1 is preferentially expressed in GSCs and also predicts GBM poor prognosis. Disrupting PTPRZ1 abrogated GSC maintenance and tumorigenic potential. Moreover, blocking the PTN-PTPRZ1 signalling by shRNA or anti-PTPRZ1 antibody potently suppressed GBM tumour growth and prolonged animal survival. Our study uncovered a critical molecular crosstalk between TAMs and GSCs through the PTN-PTPRZ1 paracrine signalling to support GBM malignant growth, indicating that targeting this signalling axis may have therapeutic potential. Tumour-associated macrophages (TAMs) facilitate malignant growth of glioblastoma (GBM). Here, the authors show that TAMs support glioma stem cell renewal via paracrine signalling to the pleiotrophin receptor PTPRZ1 and that blocking this axis results in increased survival of tumour-bearing animals. Intense infiltration of tumour-associated macrophages (TAMs) facilitates malignant growth of glioblastoma (GBM), but the underlying mechanisms remain undefined. Herein, we report that TAMs secrete abundant pleiotrophin (PTN) to stimulate glioma stem cells (GSCs) through its receptor PTPRZ1 thus promoting GBM malignant growth through PTN-PTPRZ1 paracrine signalling. PTN expression correlates with infiltration of CD11b+/CD163+ TAMs and poor prognosis of GBM patients. Co-implantation of M2-like macrophages (MLCs) promoted GSC-driven tumour growth, but silencing PTN expression in MLCs mitigated their pro-tumorigenic activity. The PTN receptor PTPRZ1 is preferentially expressed in GSCs and also predicts GBM poor prognosis. Disrupting PTPRZ1 abrogated GSC maintenance and tumorigenic potential. Moreover, blocking the PTN-PTPRZ1 signalling by shRNA or anti-PTPRZ1 antibody potently suppressed GBM tumour growth and prolonged animal survival. Our study uncovered a critical molecular crosstalk between TAMs and GSCs through the PTN-PTPRZ1 paracrine signalling to support GBM malignant growth, indicating that targeting this signalling axis may have therapeutic potential.Intense infiltration of tumour-associated macrophages (TAMs) facilitates malignant growth of glioblastoma (GBM), but the underlying mechanisms remain undefined. Herein, we report that TAMs secrete abundant pleiotrophin (PTN) to stimulate glioma stem cells (GSCs) through its receptor PTPRZ1 thus promoting GBM malignant growth through PTN-PTPRZ1 paracrine signalling. PTN expression correlates with infiltration of CD11b+/CD163+ TAMs and poor prognosis of GBM patients. Co-implantation of M2-like macrophages (MLCs) promoted GSC-driven tumour growth, but silencing PTN expression in MLCs mitigated their pro-tumorigenic activity. The PTN receptor PTPRZ1 is preferentially expressed in GSCs and also predicts GBM poor prognosis. Disrupting PTPRZ1 abrogated GSC maintenance and tumorigenic potential. Moreover, blocking the PTN-PTPRZ1 signalling by shRNA or anti-PTPRZ1 antibody potently suppressed GBM tumour growth and prolonged animal survival. Our study uncovered a critical molecular crosstalk between TAMs and GSCs through the PTN-PTPRZ1 paracrine signalling to support GBM malignant growth, indicating that targeting this signalling axis may have therapeutic potential. Intense infiltration of tumour-associated macrophages (TAMs) facilitates malignant growth of glioblastoma (GBM), but the underlying mechanisms remain undefined. Herein, we report that TAMs secrete abundant pleiotrophin (PTN) to stimulate glioma stem cells (GSCs) through its receptor PTPRZ1 thus promoting GBM malignant growth through PTN–PTPRZ1 paracrine signalling. PTN expression correlates with infiltration of CD11b + /CD163 + TAMs and poor prognosis of GBM patients. Co-implantation of M2-like macrophages (MLCs) promoted GSC-driven tumour growth, but silencing PTN expression in MLCs mitigated their pro-tumorigenic activity. The PTN receptor PTPRZ1 is preferentially expressed in GSCs and also predicts GBM poor prognosis. Disrupting PTPRZ1 abrogated GSC maintenance and tumorigenic potential. Moreover, blocking the PTN–PTPRZ1 signalling by shRNA or anti-PTPRZ1 antibody potently suppressed GBM tumour growth and prolonged animal survival. Our study uncovered a critical molecular crosstalk between TAMs and GSCs through the PTN–PTPRZ1 paracrine signalling to support GBM malignant growth, indicating that targeting this signalling axis may have therapeutic potential. |
| ArticleNumber | 15080 |
| Author | Yu, Shi-Cang Zhang, Xian-Chao Ping, Yi-Fang Rich, Jeremy N Cao, Mian-Fu Huang, Zhi Bian, Xiu-Wu Zhou, Wenchao He, Zhi-Cheng Long, Hua Lan, Xun Bao, Shideng Chen, Cong Zhang, Lin Cui, You-Hong Fu, Ti-Wei Zhang, Xia Fang, Xiaoguang Feng, Hua Bian, Bai-Shi-Jiao Zhou, Kai Chen, Lu Liu, Qing Yao, Xiao-Hong Zhang, Xiao-Ning Shi, Yu Wang, Xiuxing |
| Author_xml | – sequence: 1 givenname: Yu surname: Shi fullname: Shi, Yu organization: Institute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical University, The Key Laboratory of Tumour Immunopathology, The Ministry of Education of China – sequence: 2 givenname: Yi-Fang surname: Ping fullname: Ping, Yi-Fang organization: Institute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical University, The Key Laboratory of Tumour Immunopathology, The Ministry of Education of China – sequence: 3 givenname: Wenchao surname: Zhou fullname: Zhou, Wenchao organization: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic – sequence: 4 givenname: Zhi-Cheng surname: He fullname: He, Zhi-Cheng organization: Institute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical University, The Key Laboratory of Tumour Immunopathology, The Ministry of Education of China – sequence: 5 givenname: Cong surname: Chen fullname: Chen, Cong organization: Institute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical University, The Key Laboratory of Tumour Immunopathology, The Ministry of Education of China, Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic – sequence: 6 givenname: Bai-Shi-Jiao surname: Bian fullname: Bian, Bai-Shi-Jiao organization: Department of Ophthalmology, Southwest Hospital, The Third Military Medical University – sequence: 7 givenname: Lin surname: Zhang fullname: Zhang, Lin organization: Department of Neurology, Xijing Hospital, The Fourth Military Medical University – sequence: 8 givenname: Lu surname: Chen fullname: Chen, Lu organization: Institute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical University, The Key Laboratory of Tumour Immunopathology, The Ministry of Education of China – sequence: 9 givenname: Xun surname: Lan fullname: Lan, Xun organization: Department of Genetics, Stanford University – sequence: 10 givenname: Xian-Chao surname: Zhang fullname: Zhang, Xian-Chao organization: Institute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical University, The Key Laboratory of Tumour Immunopathology, The Ministry of Education of China – sequence: 11 givenname: Kai surname: Zhou fullname: Zhou, Kai organization: Institute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical University, The Key Laboratory of Tumour Immunopathology, The Ministry of Education of China – sequence: 12 givenname: Qing surname: Liu fullname: Liu, Qing organization: Institute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical University, The Key Laboratory of Tumour Immunopathology, The Ministry of Education of China – sequence: 13 givenname: Hua surname: Long fullname: Long, Hua organization: Institute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical University, The Key Laboratory of Tumour Immunopathology, The Ministry of Education of China – sequence: 14 givenname: Ti-Wei surname: Fu fullname: Fu, Ti-Wei organization: Institute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical University, The Key Laboratory of Tumour Immunopathology, The Ministry of Education of China – sequence: 15 givenname: Xiao-Ning surname: Zhang fullname: Zhang, Xiao-Ning organization: Institute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical University, The Key Laboratory of Tumour Immunopathology, The Ministry of Education of China – sequence: 16 givenname: Mian-Fu surname: Cao fullname: Cao, Mian-Fu organization: Institute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical University, The Key Laboratory of Tumour Immunopathology, The Ministry of Education of China – sequence: 17 givenname: Zhi surname: Huang fullname: Huang, Zhi organization: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic – sequence: 18 givenname: Xiaoguang surname: Fang fullname: Fang, Xiaoguang organization: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic – sequence: 19 givenname: Xiuxing surname: Wang fullname: Wang, Xiuxing organization: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic – sequence: 20 givenname: Hua surname: Feng fullname: Feng, Hua organization: Department of Neurosurgery, Southwest Hospital, The Third Military Medical University – sequence: 21 givenname: Xiao-Hong surname: Yao fullname: Yao, Xiao-Hong organization: Institute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical University, The Key Laboratory of Tumour Immunopathology, The Ministry of Education of China – sequence: 22 givenname: Shi-Cang surname: Yu fullname: Yu, Shi-Cang organization: Institute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical University, The Key Laboratory of Tumour Immunopathology, The Ministry of Education of China – sequence: 23 givenname: You-Hong surname: Cui fullname: Cui, You-Hong organization: Institute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical University, The Key Laboratory of Tumour Immunopathology, The Ministry of Education of China – sequence: 24 givenname: Xia surname: Zhang fullname: Zhang, Xia organization: Institute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical University, The Key Laboratory of Tumour Immunopathology, The Ministry of Education of China – sequence: 25 givenname: Jeremy N surname: Rich fullname: Rich, Jeremy N organization: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic – sequence: 26 givenname: Shideng surname: Bao fullname: Bao, Shideng email: baos@ccf.org organization: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic – sequence: 27 givenname: Xiu-Wu surname: Bian fullname: Bian, Xiu-Wu email: bianxiuwu@263.net organization: Institute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical University, The Key Laboratory of Tumour Immunopathology, The Ministry of Education of China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28569747$$D View this record in MEDLINE/PubMed |
| BookMark | eNptkt9rFDEQxxep2Fr75LsEfBH0NNlNdpMXQYo_CgWLnC--hEl2di9HdnMmOUXwjzfXa-VampeEmc9882VmnlZHc5ixqp4z-pbRRr6bbZimxASV9FF1UlPOFqyrm6OD93F1ltKaltMoJjl_Uh3XUrSq491J9Xe5ncI2LiClYB1k7MkENobNCkZMJKGNmJFsPLqQd2E3kxzIJoYplPjV8urbD0aSG2fw3s0jKfnRu2A8pBwmICnjRCx6n8gQIsnX35Exht959ax6PIBPeHZzn1bfP31cnn9ZXH79fHH-4XJhBavzorGDBdnggBIkE4xBh0bWFDrDBTedEkbUA9JeKStUNwhlRMsH6EEpA71oTquLvW4fYK030U0Q_-gATl8HQhw1xOysRz1YRntuOBgJHBtreC2Npdg1jaxbrorW-73WZmsm7C3OOYK_I3o3M7uVHsMvLXjLuKJF4NWNQAw_t5iynlzaNQhmDNukmaIFqxvGCvryHrouzSud3lOsbZXcOXpx6Oi_ldshF4DtgTLXlCIO2roM2YWdQec1o3q3S_pgl0rN63s1t7IP02_2dCrUPGI8MPoA_g-v_N4q |
| CitedBy_id | crossref_primary_10_1002_advs_202207067 crossref_primary_10_1038_s41467_022_28372_y crossref_primary_10_1016_j_canlet_2024_216801 crossref_primary_10_1016_j_lfs_2023_121558 crossref_primary_10_1038_s41467_025_56547_w crossref_primary_10_1186_s13046_024_03050_7 crossref_primary_10_1038_s41419_023_05555_z crossref_primary_10_1089_ars_2023_0262 crossref_primary_10_1016_j_intimp_2023_109990 crossref_primary_10_1002_mco2_341 crossref_primary_10_1016_j_cpt_2023_11_002 crossref_primary_10_3390_metabo12030243 crossref_primary_10_1186_s40659_024_00546_6 crossref_primary_10_3390_cancers11020241 crossref_primary_10_1016_j_prp_2023_155064 crossref_primary_10_1080_2162402X_2019_1601478 crossref_primary_10_3389_fphar_2020_00368 crossref_primary_10_1007_s11060_025_04989_z crossref_primary_10_1007_s11010_019_03571_2 crossref_primary_10_1016_j_it_2021_02_004 crossref_primary_10_1186_s13578_022_00913_4 crossref_primary_10_1002_advs_202105938 crossref_primary_10_3390_cancers13040614 crossref_primary_10_1002_1878_0261_13657 crossref_primary_10_3389_fonc_2022_822085 crossref_primary_10_1016_j_celrep_2024_115149 crossref_primary_10_1155_2023_7944102 crossref_primary_10_1084_jem_20220610 crossref_primary_10_1016_j_gendis_2023_05_025 crossref_primary_10_1038_s41392_025_02124_y crossref_primary_10_1016_j_cell_2017_08_011 crossref_primary_10_3389_fimmu_2023_1238233 crossref_primary_10_3390_cells14060413 crossref_primary_10_1002_path_5984 crossref_primary_10_1038_s41598_024_65018_z crossref_primary_10_3389_fgene_2022_1033572 crossref_primary_10_1016_j_heliyon_2024_e27004 crossref_primary_10_3389_fimmu_2020_01281 crossref_primary_10_1038_s41374_021_00724_0 crossref_primary_10_1038_s43018_021_00267_9 crossref_primary_10_1016_j_canlet_2019_04_003 crossref_primary_10_1038_s42003_021_02258_z crossref_primary_10_1093_neuonc_noab302 crossref_primary_10_3389_fonc_2022_1022716 crossref_primary_10_3390_ijms251910839 crossref_primary_10_1016_j_canlet_2022_215605 crossref_primary_10_1038_s41374_019_0345_3 crossref_primary_10_3389_fphar_2019_00377 crossref_primary_10_1038_s41388_021_02010_1 crossref_primary_10_1038_s41598_023_45249_2 crossref_primary_10_3389_fcell_2021_657472 crossref_primary_10_1186_s12964_018_0304_4 crossref_primary_10_3389_fgene_2022_882004 crossref_primary_10_1016_j_intimp_2020_107265 crossref_primary_10_1155_2023_6510571 crossref_primary_10_1038_s41568_021_00366_w crossref_primary_10_1016_j_jconrel_2022_11_025 crossref_primary_10_3390_ijms232415612 crossref_primary_10_3389_fimmu_2025_1529847 crossref_primary_10_1016_j_ejphar_2024_176692 crossref_primary_10_1016_j_stem_2019_11_015 crossref_primary_10_1007_s12539_024_00657_4 crossref_primary_10_3390_biom13020339 crossref_primary_10_1038_s41467_020_16789_2 crossref_primary_10_1038_s41467_020_16827_z crossref_primary_10_1136_jitc_2024_008967 crossref_primary_10_3389_fonc_2021_751792 crossref_primary_10_1101_gad_324301_119 crossref_primary_10_3389_fcell_2021_706286 crossref_primary_10_3389_fgene_2022_954713 crossref_primary_10_1186_s12916_024_03573_y crossref_primary_10_1038_s41388_018_0515_6 crossref_primary_10_3389_fimmu_2021_800128 crossref_primary_10_3389_fimmu_2020_544563 crossref_primary_10_1016_j_jbc_2023_105128 crossref_primary_10_1158_2326_6066_CIR_23_1094 crossref_primary_10_2147_OTT_S257050 crossref_primary_10_3390_cancers16213683 crossref_primary_10_1080_14728222_2020_1762568 crossref_primary_10_3390_cancers13174255 crossref_primary_10_1016_j_cellsig_2024_111191 crossref_primary_10_3390_ijms222413382 crossref_primary_10_1158_1078_0432_CCR_17_1628 crossref_primary_10_3390_life12081225 crossref_primary_10_3390_s24092865 crossref_primary_10_1534_genetics_118_300864 crossref_primary_10_1186_s12974_020_1709_8 crossref_primary_10_1016_j_ccell_2024_03_013 crossref_primary_10_1158_0008_5472_CAN_24_0018 crossref_primary_10_1016_j_heliyon_2024_e40806 crossref_primary_10_1007_s12539_019_00325_y crossref_primary_10_1016_j_celrep_2023_113022 crossref_primary_10_1016_j_bcp_2022_114955 crossref_primary_10_1155_2022_8903482 crossref_primary_10_1016_j_foodres_2023_113770 crossref_primary_10_1002_jev2_12278 crossref_primary_10_1016_j_tranon_2023_101790 crossref_primary_10_1038_s41467_023_39933_0 crossref_primary_10_1016_j_cell_2020_04_055 crossref_primary_10_1111_cns_13892 crossref_primary_10_1186_s40478_021_01124_7 crossref_primary_10_1016_j_bbrc_2020_10_037 crossref_primary_10_1016_j_cytogfr_2024_10_009 crossref_primary_10_1016_j_advnut_2023_05_007 crossref_primary_10_3389_fcell_2022_902394 crossref_primary_10_1016_j_actbio_2025_01_050 crossref_primary_10_1093_neuonc_noy032 crossref_primary_10_3389_fonc_2023_990551 crossref_primary_10_1016_j_heliyon_2023_e19114 crossref_primary_10_7554_eLife_52253 crossref_primary_10_1016_j_cej_2023_145557 crossref_primary_10_3390_ijms21155497 crossref_primary_10_1093_noajnl_vdaa055 crossref_primary_10_3389_fonc_2021_638397 crossref_primary_10_1089_ten_tea_2020_0335 crossref_primary_10_3389_fonc_2024_1498524 crossref_primary_10_1002_cbic_202400848 crossref_primary_10_31083_j_fbl2812362 crossref_primary_10_1007_s10120_024_01486_6 crossref_primary_10_1038_s41467_024_52888_0 crossref_primary_10_1136_jitc_2024_009175 crossref_primary_10_1002_smll_202301439 crossref_primary_10_1186_s40478_024_01755_6 crossref_primary_10_1016_j_isci_2024_109270 crossref_primary_10_1016_j_canlet_2019_09_004 crossref_primary_10_3389_fneur_2022_1047162 crossref_primary_10_3390_cancers16142500 crossref_primary_10_1158_2326_6066_CIR_21_1050 crossref_primary_10_3390_biom12060850 crossref_primary_10_1172_JCI129061 crossref_primary_10_1039_C9NR06505A crossref_primary_10_1002_prm2_12090 crossref_primary_10_3389_fonc_2023_1111570 crossref_primary_10_3390_cancers16020308 crossref_primary_10_1038_s41388_022_02393_9 crossref_primary_10_3390_ijms21155278 crossref_primary_10_3389_fimmu_2022_845223 crossref_primary_10_1111_cas_14078 crossref_primary_10_1093_nar_gkac200 crossref_primary_10_3389_fcell_2021_729136 crossref_primary_10_1016_j_csbj_2024_11_016 crossref_primary_10_3389_fimmu_2022_819080 crossref_primary_10_1016_j_cell_2018_09_038 crossref_primary_10_1073_pnas_2222084120 crossref_primary_10_1002_mco2_176 crossref_primary_10_1021_acs_nanolett_2c01863 crossref_primary_10_1038_s41422_020_0338_1 crossref_primary_10_1007_s10014_021_00404_3 crossref_primary_10_1172_JCI143397 crossref_primary_10_3390_ijms24098093 crossref_primary_10_1002_ctm2_181 crossref_primary_10_1002_ctm2_70013 crossref_primary_10_1002_adtp_202400100 crossref_primary_10_1016_j_ydbio_2025_02_004 crossref_primary_10_1038_s41419_018_1015_x crossref_primary_10_1186_s12883_024_03558_7 crossref_primary_10_3389_fimmu_2022_841404 crossref_primary_10_1038_s41467_021_27667_w crossref_primary_10_1080_2162402X_2023_2290790 crossref_primary_10_26599_BSA_2020_9050015 crossref_primary_10_1038_s41388_019_0952_x crossref_primary_10_3390_biomedicines13030695 crossref_primary_10_1016_j_bbadis_2023_166695 crossref_primary_10_1016_j_isci_2022_105329 crossref_primary_10_1016_j_humpath_2019_12_007 crossref_primary_10_1038_s41698_024_00522_z crossref_primary_10_1038_s41419_023_05753_9 crossref_primary_10_1038_s41467_020_18582_7 crossref_primary_10_3389_fimmu_2022_974996 crossref_primary_10_1038_s41598_023_48116_2 crossref_primary_10_1111_bpa_12690 crossref_primary_10_3390_molecules23020395 crossref_primary_10_1016_j_ccell_2023_03_004 crossref_primary_10_3390_cancers11040469 crossref_primary_10_3390_ijms23084414 crossref_primary_10_1007_s12032_022_01885_8 crossref_primary_10_1038_s41418_022_00969_2 crossref_primary_10_3788_LOP231182 crossref_primary_10_1111_cas_15773 crossref_primary_10_1016_j_ijrobp_2024_09_007 crossref_primary_10_1039_D1RA06705B crossref_primary_10_1016_j_canlet_2018_11_016 crossref_primary_10_3389_fimmu_2025_1530305 crossref_primary_10_1038_s41419_018_0957_3 crossref_primary_10_1016_j_canlet_2024_217400 crossref_primary_10_3390_cancers14051126 crossref_primary_10_1111_cas_14427 crossref_primary_10_3389_fimmu_2022_964898 crossref_primary_10_1093_neuonc_noac063 crossref_primary_10_1016_j_cellsig_2024_111231 crossref_primary_10_1021_acsabm_1c00461 crossref_primary_10_1016_j_critrevonc_2025_104657 crossref_primary_10_1016_j_isci_2022_104179 crossref_primary_10_1111_cns_13120 crossref_primary_10_1038_s41422_021_00528_3 crossref_primary_10_3390_brainsci13091269 crossref_primary_10_3390_cancers15051557 crossref_primary_10_1038_s41698_024_00717_4 crossref_primary_10_2147_JHC_S493675 crossref_primary_10_3389_fmolb_2022_974156 crossref_primary_10_1016_j_tips_2022_04_002 crossref_primary_10_1080_14737175_2018_1510321 crossref_primary_10_1186_s13148_023_01446_4 crossref_primary_10_1111_bpa_12776 crossref_primary_10_1002_cnr2_70137 crossref_primary_10_1016_j_cell_2023_12_013 crossref_primary_10_1007_s10555_023_10100_7 crossref_primary_10_1152_ajpheart_00400_2021 crossref_primary_10_3390_ijms22115775 crossref_primary_10_3390_ijms222413211 crossref_primary_10_3390_cancers15153843 crossref_primary_10_3389_fimmu_2024_1434300 crossref_primary_10_1016_j_xcrm_2024_101914 crossref_primary_10_1007_s12975_024_01265_6 crossref_primary_10_1016_j_cellsig_2023_110731 crossref_primary_10_1007_s00262_021_02885_9 crossref_primary_10_1016_j_pharmthera_2021_107985 crossref_primary_10_1016_j_imbio_2019_10_002 crossref_primary_10_1007_s12672_024_01464_5 crossref_primary_10_1186_s12935_018_0620_1 crossref_primary_10_1093_procel_pwae012 crossref_primary_10_1002_ctm2_70160 crossref_primary_10_3390_cancers15133458 crossref_primary_10_1186_s40478_021_01156_z crossref_primary_10_1038_s41392_020_0110_5 crossref_primary_10_3390_cells10092361 crossref_primary_10_3389_fimmu_2020_00140 crossref_primary_10_1038_s41420_022_01081_7 crossref_primary_10_1186_s13059_020_02140_x crossref_primary_10_3389_fimmu_2022_823910 crossref_primary_10_62347_EAQW3113 crossref_primary_10_1007_s10120_024_01567_6 crossref_primary_10_18632_oncotarget_22819 |
| Cites_doi | 10.1038/ki.2011.305 10.1158/2159-8290.CD-15-0583 10.1038/nm.3337 10.1016/j.bbrc.2005.05.007 10.1038/nn.4185 10.1038/onc.2014.75 10.1634/stemcells.2007-0372 10.1093/bioinformatics/bth349 10.1038/nm.3355 10.1158/1078-0432.CCR-04-0713 10.1182/blood-2006-08-042374 10.3390/cancers6020723 10.1023/A:1013805915224 10.1038/nature05236 10.1053/j.gastro.2014.08.039 10.1073/pnas.0704366104 10.4238/2015.May.18.23 10.1093/jnen/62.12.1265 10.1016/j.it.2015.02.004 10.1073/pnas.041608698 10.1093/neuonc/not082 10.1073/pnas.1217002110 10.1158/0008-5472.CAN-08-0643 10.1158/1078-0432.CCR-14-2807 10.1016/j.cell.2013.02.021 10.1038/ncb3090 10.1016/j.cell.2014.02.030 10.1038/nm.2119 10.1016/j.jim.2009.06.008 10.1136/gutjnl-2014-308176 10.1038/nrc3973 10.1111/j.1600-065X.2008.00607.x 10.1038/sj.onc.1210949 10.1016/j.ccr.2006.11.020 10.4049/jimmunol.1103248 10.1016/j.ccr.2009.03.018 10.1093/jnci/84.24.1926 10.1016/j.immuni.2014.06.010 10.1016/j.stem.2011.04.013 10.1093/neuonc/noq082 10.1038/sj.cdd.4402011 10.1002/(SICI)1097-0215(19990702)82:1<12::AID-IJC3>3.0.CO;2-O 10.1038/onc.2013.590 10.1038/onc.2013.168 10.1093/jnci/dju162 10.1016/j.ccell.2015.02.015 10.1016/j.febslet.2006.06.041 10.1016/S1471-4906(02)02302-5 10.1074/jbc.M502614200 10.1016/j.jocn.2015.02.008 10.1126/scisignal.aaa1690 10.1002/path.2370 10.3389/fonc.2012.00192 10.1038/279328a0 10.1016/j.ccr.2011.03.004 10.1158/1078-0432.CCR-12-1940 10.1006/abbi.2001.2705 10.7314/APJCP.2015.16.4.1421 10.1093/nar/gki093 10.1186/1471-2407-12-537 10.1007/s00404-010-1693-9 10.1073/pnas.020487997 10.1016/j.addr.2014.08.012 10.1016/S1470-2045(09)70025-7 10.1158/0008-5472.CAN-13-2169 10.1038/cdd.2016.110 10.1593/neo.81040 10.1242/dev.121.1.37 10.1684/ecn.2009.0172 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2017 Copyright Nature Publishing Group Jun 2017 Copyright © 2017, The Author(s) 2017 The Author(s) |
| Copyright_xml | – notice: The Author(s) 2017 – notice: Copyright Nature Publishing Group Jun 2017 – notice: Copyright © 2017, The Author(s) 2017 The Author(s) |
| DBID | C6C AAYXX CITATION NPM 3V. 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7T7 7TM 7TO 7X7 7XB 88E 8AO 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA ARAPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7P P5Z P62 P64 PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS RC3 SOI 7X8 5PM DOA |
| DOI | 10.1038/ncomms15080 |
| DatabaseName | Springer Nature OA Free Journals CrossRef PubMed ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Ecology Abstracts Entomology Abstracts (Full archive) Environment Abstracts Immunology Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Aerospace Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Biological Science Collection ProQuest Health & Medical Collection Medical Database Biological Science Database Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China Genetics Abstracts Environment Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ - Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed Publicly Available Content Database ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (New) ProQuest Medical Library (Alumni) Advanced Technologies & Aerospace Collection ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Entomology Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) AIDS and Cancer Research Abstracts ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Immunology Abstracts Environment Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Publicly Available Content Database PubMed MEDLINE - Academic CrossRef |
| Database_xml | – sequence: 1 dbid: C6C name: Springer Nature OA Free Journals url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 3 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 2041-1723 |
| EndPage | 17 |
| ExternalDocumentID | oai_doaj_org_article_fc10d4b4ab8a4e3cb428bc0e73382649 PMC5461490 4322636355 28569747 10_1038_ncomms15080 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GeographicLocations | United States--US China |
| GeographicLocations_xml | – name: China – name: United States--US |
| GrantInformation_xml | – fundername: NINDS NIH HHS grantid: R01 NS099175 – fundername: NCI NIH HHS grantid: R01 CA184090 – fundername: NINDS NIH HHS grantid: R01 NS091080 |
| GroupedDBID | --- 0R~ 39C 3V. 53G 5VS 70F 7X7 88E 8AO 8FE 8FG 8FH 8FI 8FJ AAHBH AAJSJ ABUWG ACGFO ACGFS ACIWK ACMJI ACPRK ACSMW ADBBV ADFRT ADMLS ADRAZ AENEX AEUYN AFKRA AFRAH AHMBA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH AOIJS ARAPS ASPBG AVWKF AZFZN BAPOH BBNVY BCNDV BENPR BGLVJ BHPHI BPHCQ BVXVI C6C CCPQU DIK EBLON EBS EE. EMOBN F5P FEDTE FYUFA GROUPED_DOAJ HCIFZ HMCUK HVGLF HYE HZ~ KQ8 LK8 M1P M48 M7P M~E NAO O9- OK1 P2P P62 PIMPY PQQKQ PROAC PSQYO RNS RNT RNTTT RPM SNYQT SV3 TSG UKHRP AASML AAYXX CITATION PHGZM PHGZT NPM 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7T7 7TM 7TO 7XB 8FD 8FK AARCD AZQEC C1K DWQXO FR3 GNUQQ H94 K9. P64 PJZUB PKEHL PPXIY PQEST PQGLB PQUKI PRINS RC3 SOI 7X8 5PM PUEGO |
| ID | FETCH-LOGICAL-c512t-3cfca83efe8a81511a7eb820a7b454b795b52fe0d99c597f59b564fada99bad53 |
| IEDL.DBID | M48 |
| ISSN | 2041-1723 |
| IngestDate | Wed Aug 27 01:30:35 EDT 2025 Thu Aug 21 13:18:23 EDT 2025 Fri Jul 11 16:47:58 EDT 2025 Wed Aug 13 04:08:25 EDT 2025 Thu Apr 03 07:06:47 EDT 2025 Thu Apr 24 23:12:59 EDT 2025 Tue Jul 01 02:31:42 EDT 2025 Fri Feb 21 02:41:48 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c512t-3cfca83efe8a81511a7eb820a7b454b795b52fe0d99c597f59b564fada99bad53 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1038/ncomms15080 |
| PMID | 28569747 |
| PQID | 1904166989 |
| PQPubID | 546298 |
| PageCount | 17 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_fc10d4b4ab8a4e3cb428bc0e73382649 pubmedcentral_primary_oai_pubmedcentral_nih_gov_5461490 proquest_miscellaneous_1904902311 proquest_journals_1904166989 pubmed_primary_28569747 crossref_citationtrail_10_1038_ncomms15080 crossref_primary_10_1038_ncomms15080 springer_journals_10_1038_ncomms15080 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 20170601 2017-06-01 |
| PublicationDateYYYYMMDD | 2017-06-01 |
| PublicationDate_xml | – month: 6 year: 2017 text: 20170601 day: 1 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Nature communications |
| PublicationTitleAbbrev | Nat Commun |
| PublicationTitleAlternate | Nat Commun |
| PublicationYear | 2017 |
| Publisher | Nature Publishing Group UK Nature Publishing Group Nature Portfolio |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Portfolio |
| References | Ye (CR11) 2012; 189 Wan (CR15) 2014; 147 Lathia, Heddleston, Venere, Rich (CR3) 2011; 8 Saldanha (CR69) 2004; 20 Cheng (CR41) 2013; 153 Prosniak (CR6) 2013; 19 Bao (CR21) 2006; 444 Wang (CR42) 2015; 34 Wei (CR46) 2013; 110 Miao (CR45) 2015; 34 Zhou, Bao (CR17) 2014; 6 Wellstein (CR58) 2012; 2 Soh (CR44) 2007; 25 Morello, Sadelain, Adusumilli (CR53) 2016; 6 Chen (CR54) 2007; 110 Zhang (CR61) 2015; 8 Calabrese (CR19) 2007; 11 Yamashina (CR50) 2014; 74 Wagner (CR16) 1999; 82 Kawachi, Fujikawa, Maeda, Noda (CR30) 2001; 98 Yokoi (CR24) 2012; 81 Ma, Ye, Xie, Zhou, Lu (CR33) 2011; 284 Lu-Emerson (CR7) 2013; 15 Stupp (CR1) 2009; 10 Garris, Pittet (CR4) 2013; 19 Hambardzumyan, Gutmann, Kettenmann (CR5) 2015; 19 Guryanova (CR40) 2011; 19 Noy, Pollard (CR51) 2014; 41 Mantovani, Sozzani, Locati, Allavena, Sica (CR9) 2002; 23 Makinoshima (CR32) 2012; 12 Friedman (CR43) 1992; 84 Allavena, Sica, Garlanda, Mantovani (CR10) 2008; 222 Michelotti (CR59) 2016; 65 Mitsiadis (CR23) 1995; 121 Komohara, Ohnishi, Kuratsu, Takeya (CR39) 2008; 216 Zhou (CR13) 2015; 17 Xu (CR12) 2014; 106 Himburg (CR60) 2010; 16 Koyama-Nasu (CR62) 2014; 33 Pyonteck (CR14) 2013; 19 Rape, Ananthanarayanan, Kumar (CR2) 2014; 79–80 Ostuni, Kratochvill, Murray, Natoli (CR8) 2015; 36 Suva (CR68) 2014; 157 Grzelinski (CR55) 2009; 11 Deuel, Zhang, Yeh, Silos-Santiago, Wang (CR29) 2002; 397 Shi (CR64) 2017; 24 Martin-Manso (CR38) 2008; 68 Fukada (CR63) 2006; 580 Koren, Anderson, Larrick (CR37) 1979; 279 Chang (CR26) 2007; 104 Goldmann, Otto, Vollmer (CR35) 2000; 38 Papadimitriou (CR25) 2009; 20 Shi (CR65) 2015; 21 Pariser, Ezquerra, Herradon, Perez-Pinera, Deuel (CR31) 2005; 332 Melero (CR52) 2015; 15 Meng (CR28) 2000; 97 Chen (CR36) 2005; 33 Tang, Feng, Ye (CR47) 2007; 14 Morokoff, Ng, Gogos, Kaye (CR49) 2015; 22 Wu (CR18) 2010; 12 Li (CR20) 2009; 15 Gunther (CR67) 2008; 27 Camp, Dolled-Filhart, Rimm (CR70) 2004; 10 Lu (CR57) 2005; 280 An, Li, Cheng (CR48) 2015; 14 Hu, Smyth (CR66) 2009; 347 Ulbricht (CR34) 2003; 62 Deininger, Pater, Strik, Meyermann (CR22) 2001; 55 Du, Shi, Ji, Yu (CR27) 2015; 16 Ruffell, Coussens (CR56) 2015; 27 Y Chang (BFncomms15080_CR26) 2007; 104 M Grzelinski (BFncomms15080_CR55) 2009; 11 HS Friedman (BFncomms15080_CR43) 1992; 84 L Cheng (BFncomms15080_CR41) 2013; 153 L An (BFncomms15080_CR48) 2015; 14 H Chen (BFncomms15080_CR54) 2007; 110 I Melero (BFncomms15080_CR52) 2015; 15 XZ Ye (BFncomms15080_CR11) 2012; 189 P Allavena (BFncomms15080_CR10) 2008; 222 RL Camp (BFncomms15080_CR70) 2004; 10 T Yamashina (BFncomms15080_CR50) 2014; 74 B Ruffell (BFncomms15080_CR56) 2015; 27 Y Wei (BFncomms15080_CR46) 2013; 110 JD Lathia (BFncomms15080_CR3) 2011; 8 W Zhou (BFncomms15080_CR17) 2014; 6 H Makinoshima (BFncomms15080_CR32) 2012; 12 S Wagner (BFncomms15080_CR16) 1999; 82 MH Deininger (BFncomms15080_CR22) 2001; 55 H Kawachi (BFncomms15080_CR30) 2001; 98 ML Suva (BFncomms15080_CR68) 2014; 157 HA Himburg (BFncomms15080_CR60) 2010; 16 Z Wang (BFncomms15080_CR42) 2015; 34 BS Soh (BFncomms15080_CR44) 2007; 25 S Bao (BFncomms15080_CR21) 2006; 444 OA Guryanova (BFncomms15080_CR40) 2011; 19 A Rape (BFncomms15080_CR2) 2014; 79–80 H Miao (BFncomms15080_CR45) 2015; 34 Y Shi (BFncomms15080_CR65) 2015; 21 H Yokoi (BFncomms15080_CR24) 2012; 81 D Hambardzumyan (BFncomms15080_CR5) 2015; 19 A Mantovani (BFncomms15080_CR9) 2002; 23 S Xu (BFncomms15080_CR12) 2014; 106 TA Mitsiadis (BFncomms15080_CR23) 1995; 121 R Ostuni (BFncomms15080_CR8) 2015; 36 GA Michelotti (BFncomms15080_CR59) 2016; 65 Y Shi (BFncomms15080_CR64) 2017; 24 A Morokoff (BFncomms15080_CR49) 2015; 22 C Calabrese (BFncomms15080_CR19) 2007; 11 S Wan (BFncomms15080_CR15) 2014; 147 K Meng (BFncomms15080_CR28) 2000; 97 G Martin-Manso (BFncomms15080_CR38) 2008; 68 KV Lu (BFncomms15080_CR57) 2005; 280 TF Deuel (BFncomms15080_CR29) 2002; 397 Y Chen (BFncomms15080_CR36) 2005; 33 AJ Saldanha (BFncomms15080_CR69) 2004; 20 Y Komohara (BFncomms15080_CR39) 2008; 216 M Prosniak (BFncomms15080_CR6) 2013; 19 R Noy (BFncomms15080_CR51) 2014; 41 Y Hu (BFncomms15080_CR66) 2009; 347 HS Gunther (BFncomms15080_CR67) 2008; 27 M Fukada (BFncomms15080_CR63) 2006; 580 A Wu (BFncomms15080_CR18) 2010; 12 T Goldmann (BFncomms15080_CR35) 2000; 38 A Morello (BFncomms15080_CR53) 2016; 6 E Papadimitriou (BFncomms15080_CR25) 2009; 20 Y Ma (BFncomms15080_CR33) 2011; 284 HS Koren (BFncomms15080_CR37) 1979; 279 H Pariser (BFncomms15080_CR31) 2005; 332 SM Pyonteck (BFncomms15080_CR14) 2013; 19 X Tang (BFncomms15080_CR47) 2007; 14 ZY Du (BFncomms15080_CR27) 2015; 16 L Zhang (BFncomms15080_CR61) 2015; 8 C Lu-Emerson (BFncomms15080_CR7) 2013; 15 A Wellstein (BFncomms15080_CR58) 2012; 2 R Stupp (BFncomms15080_CR1) 2009; 10 Z Li (BFncomms15080_CR20) 2009; 15 R Koyama-Nasu (BFncomms15080_CR62) 2014; 33 W Zhou (BFncomms15080_CR13) 2015; 17 U Ulbricht (BFncomms15080_CR34) 2003; 62 C Garris (BFncomms15080_CR4) 2013; 19 20882291 - Arch Gynecol Obstet. 2011 Sep;284(3):699-704 11795867 - Arch Biochem Biophys. 2002 Jan 15;397(2):162-71 1334154 - J Natl Cancer Inst. 1992 Dec 16;84(24):1926-31 20667896 - Neuro Oncol. 2010 Nov;12(11):1113-25 10706604 - Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2603-8 26645582 - Sci Signal. 2015 Dec 08;8(406):ra125 19477429 - Cancer Cell. 2009 Jun 2;15(6):501-13 25743809 - Asian Pac J Cancer Prev. 2015;16(4):1421-5 22664874 - J Immunol. 2012 Jul 1;189(1):444-53 16814777 - FEBS Lett. 2006 Jul 24;580(17):4051-6 19269895 - Lancet Oncol. 2009 May;10 (5):459-66 17578909 - Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10888-93 17823238 - Stem Cells. 2007 Dec;25(12):3029-37 24726434 - Cell. 2014 Apr 24;157(3):580-94 10360813 - Int J Cancer. 1999 Jul 2;82(1):12-6 21481791 - Cancer Cell. 2011 Apr 12;19(4):498-511 24704830 - Oncogene. 2015 Mar 12;34(11):1407-19 25580734 - Nat Cell Biol. 2015 Feb;17(2):170-82 18364000 - Immunol Rev. 2008 Apr;222:155-61 15908427 - J Biol Chem. 2005 Jul 22;280(29):26953-64 23540695 - Cell. 2013 Mar 28;153(1):139-52 18037961 - Oncogene. 2008 May 1;27(20):2897-909 21549324 - Cell Stem Cell. 2011 May 6;8(5):482-5 20305662 - Nat Med. 2010 Apr;16(4):475-82 24638980 - Cancer Res. 2014 May 15;74(10):2698-709 25770924 - Trends Immunol. 2015 Apr;36(4):229-39 24100977 - Nat Med. 2013 Oct;19(10):1207-8 25858805 - Cancer Cell. 2015 Apr 13;27(4):462-72 24675569 - Cancers (Basel). 2014 Mar 26;6(2):723-40 26713745 - Nat Neurosci. 2016 Jan;19(1):20-7 17051156 - Nature. 2006 Dec 7;444(7120):756-60 25957782 - J Clin Neurosci. 2015 Aug;22(8):1219-26 11859968 - J Neurooncol. 2001 Dec;55(3):141-7 15608170 - Nucleic Acids Res. 2005 Jan 1;33(Database issue):D169-73 24056773 - Nat Med. 2013 Oct;19(10):1264-72 25174308 - Adv Drug Deliv Rev. 2014 Dec 15;79-80:172-83 23741072 - Clin Cancer Res. 2013 Jul 15;19(14):3776-86 23828240 - Neuro Oncol. 2013 Aug;15(8):1079-87 23569237 - Proc Natl Acad Sci U S A. 2013 Apr 23;110(17 ):6829-34 26205340 - Nat Rev Cancer. 2015 Aug;15(8):457-72 18553315 - J Pathol. 2008 Sep;216(1):15-24 23170925 - BMC Cancer. 2012 Nov 21;12:537 16841086 - Cell Death Differ. 2007 Feb;14(2):368-77 450085 - Nature. 1979 May 24;279(5711):328-31 12401408 - Trends Immunol. 2002 Nov;23(11):549-55 26023083 - Clin Cancer Res. 2015 Sep 1;21(17):4004-13 14692702 - J Neuropathol Exp Neurol. 2003 Dec;62(12):1265-75 15925565 - Biochem Biophys Res Commun. 2005 Jul 8;332(3):664-9 25596181 - Gut. 2016 Apr;65(4):683-92 19177199 - Neoplasia. 2009 Feb;11(2):145-56 24488013 - Oncogene. 2015 Jan 29;34(5):558-67 23267434 - Front Oncol. 2012 Dec 19;2:192 25035953 - Immunity. 2014 Jul 17;41(1):49-61 25181692 - Gastroenterology. 2014 Dec;147(6):1393-404 21881556 - Kidney Int. 2012 Jan;81(2):160-9 26125726 - Genet Mol Res. 2015 May 18;14(2):5304-9 20167557 - Eur Cytokine Netw. 2009 Dec;20(4):180-90 18757424 - Cancer Res. 2008 Sep 1;68(17):7090-9 17369488 - Blood. 2007 Jul 1;110(1):287-95 26503962 - Cancer Discov. 2016 Feb;6(2):133-46 15180930 - Bioinformatics. 2004 Nov 22;20(17):3246-8 24974128 - J Natl Cancer Inst. 2014 Jun 28;106(8):null 17222791 - Cancer Cell. 2007 Jan;11(1):69-82 19567251 - J Immunol Methods. 2009 Aug 15;347(1-2):70-8 23686309 - Oncogene. 2014 Apr 24;33(17):2236-44 10763119 - Folia Histochem Cytobiol. 2000;38(1):19-20 7867507 - Development. 1995 Jan;121(1):37-51 27740621 - Cell Death Differ. 2017 Jan;24(1):167-180 11381105 - Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6593-8 15534099 - Clin Cancer Res. 2004 Nov 1;10(21):7252-9 |
| References_xml | – volume: 81 start-page: 160 year: 2012 end-page: 169 ident: CR24 article-title: Pleiotrophin triggers inflammation and increased peritoneal permeability leading to peritoneal fibrosis publication-title: Kidney Int. doi: 10.1038/ki.2011.305 – volume: 38 start-page: 19 year: 2000 end-page: 20 ident: CR35 article-title: A receptor-type protein tyrosine phosphatase PTP zeta is expressed in human cutaneous melanomas publication-title: Folia Histochem. Cytobiol. – volume: 6 start-page: 133 year: 2016 end-page: 146 ident: CR53 article-title: Mesothelin-targeted CARs: driving T cells to solid tumors publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-15-0583 – volume: 19 start-page: 1264 year: 2013 end-page: 1272 ident: CR14 article-title: CSF-1R inhibition alters macrophage polarization and blocks glioma progression publication-title: Nat. Med. doi: 10.1038/nm.3337 – volume: 332 start-page: 664 year: 2005 end-page: 669 ident: CR31 article-title: Fyn is a downstream target of the pleiotrophin/receptor protein tyrosine phosphatase beta/zeta-signaling pathway: regulation of tyrosine phosphorylation of Fyn by pleiotrophin publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2005.05.007 – volume: 19 start-page: 20 year: 2015 end-page: 27 ident: CR5 article-title: The role of microglia and macrophages in glioma maintenance and progression publication-title: Nat. Neurosci. doi: 10.1038/nn.4185 – volume: 34 start-page: 1407 year: 2015 end-page: 1419 ident: CR42 article-title: Oncogenic miR-20a and miR-106a enhance the invasiveness of human glioma stem cells by directly targeting TIMP-2 publication-title: Oncogene doi: 10.1038/onc.2014.75 – volume: 25 start-page: 3029 year: 2007 end-page: 3037 ident: CR44 article-title: Pleiotrophin enhances clonal growth and long-term expansion of human embryonic stem cells publication-title: Stem Cells doi: 10.1634/stemcells.2007-0372 – volume: 20 start-page: 3246 year: 2004 end-page: 3248 ident: CR69 article-title: Java Treeview—extensible visualization of microarray data publication-title: Bioinformatics doi: 10.1093/bioinformatics/bth349 – volume: 19 start-page: 1207 year: 2013 end-page: 1208 ident: CR4 article-title: Therapeutically reeducating macrophages to treat GBM publication-title: Nat. Med. doi: 10.1038/nm.3355 – volume: 10 start-page: 7252 year: 2004 end-page: 7259 ident: CR70 article-title: X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-04-0713 – volume: 110 start-page: 287 year: 2007 end-page: 295 ident: CR54 article-title: Pleiotrophin is highly expressed by myeloma cells and promotes myeloma tumor growth publication-title: Blood doi: 10.1182/blood-2006-08-042374 – volume: 6 start-page: 723 year: 2014 end-page: 740 ident: CR17 article-title: Reciprocal supportive interplay between glioblastoma and tumor-associated macrophages publication-title: Cancers doi: 10.3390/cancers6020723 – volume: 55 start-page: 141 year: 2001 end-page: 147 ident: CR22 article-title: Macrophage/microglial cell subpopulations in glioblastoma multiforme relapses are differentially altered by radiochemotherapy publication-title: J. Neurooncol. doi: 10.1023/A:1013805915224 – volume: 444 start-page: 756 year: 2006 end-page: 760 ident: CR21 article-title: Glioma stem cells promote radioresistance by preferential activation of the DNA damage response publication-title: Nature doi: 10.1038/nature05236 – volume: 147 start-page: 1393 year: 2014 end-page: 1404 ident: CR15 article-title: Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells publication-title: Gastroenterology doi: 10.1053/j.gastro.2014.08.039 – volume: 104 start-page: 10888 year: 2007 end-page: 10893 ident: CR26 article-title: Secretion of pleiotrophin stimulates breast cancer progression through remodeling of the tumor microenvironment publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0704366104 – volume: 14 start-page: 5304 year: 2015 end-page: 5309 ident: CR48 article-title: Fyn arrests swainsonine-induced apoptosis in 293T cells via Akt and its phosphorylation publication-title: Genet. Mol. Res. doi: 10.4238/2015.May.18.23 – volume: 62 start-page: 1265 year: 2003 end-page: 1275 ident: CR34 article-title: Expression and function of the receptor protein tyrosine phosphatase zeta and its ligand pleiotrophin in human astrocytomas publication-title: J. Neuropathol. Exp. Neurol. doi: 10.1093/jnen/62.12.1265 – volume: 36 start-page: 229 year: 2015 end-page: 239 ident: CR8 article-title: Macrophages and cancer: from mechanisms to therapeutic implications publication-title: Trends Immunol. doi: 10.1016/j.it.2015.02.004 – volume: 98 start-page: 6593 year: 2001 end-page: 6598 ident: CR30 article-title: Identification of GIT1/Cat-1 as a substrate molecule of protein tyrosine phosphatase zeta/beta by the yeast substrate-trapping system publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.041608698 – volume: 15 start-page: 1079 year: 2013 end-page: 1087 ident: CR7 article-title: Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma publication-title: Neuro Oncol. doi: 10.1093/neuonc/not082 – volume: 20 start-page: 180 year: 2009 end-page: 190 ident: CR25 article-title: Roles of pleiotrophin in tumor growth and angiogenesis publication-title: Eur. Cytokine Netw. – volume: 110 start-page: 6829 year: 2013 end-page: 6834 ident: CR46 article-title: Activation of PI3K/Akt pathway by CD133-p85 interaction promotes tumorigenic capacity of glioma stem cells publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1217002110 – volume: 68 start-page: 7090 year: 2008 end-page: 7099 ident: CR38 article-title: Thrombospondin 1 promotes tumor macrophage recruitment and enhances tumor cell cytotoxicity of differentiated U937 cells publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-08-0643 – volume: 21 start-page: 4004 year: 2015 end-page: 4013 ident: CR65 article-title: miR-663 suppresses oncogenic function of CXCR4 in glioblastoma publication-title: Clin Cancer Res. doi: 10.1158/1078-0432.CCR-14-2807 – volume: 153 start-page: 139 year: 2013 end-page: 152 ident: CR41 article-title: Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth publication-title: Cell doi: 10.1016/j.cell.2013.02.021 – volume: 17 start-page: 170 year: 2015 end-page: 182 ident: CR13 article-title: Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth publication-title: Nat. Cell Biol. doi: 10.1038/ncb3090 – volume: 157 start-page: 580 year: 2014 end-page: 594 ident: CR68 article-title: Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells publication-title: Cell doi: 10.1016/j.cell.2014.02.030 – volume: 16 start-page: 475 year: 2010 end-page: 482 ident: CR60 article-title: Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells publication-title: Nat. Med. doi: 10.1038/nm.2119 – volume: 347 start-page: 70 year: 2009 end-page: 78 ident: CR66 article-title: ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays publication-title: J. Immunol. Methods doi: 10.1016/j.jim.2009.06.008 – volume: 65 start-page: 683 year: 2016 end-page: 692 ident: CR59 article-title: Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches publication-title: Gut doi: 10.1136/gutjnl-2014-308176 – volume: 15 start-page: 457 year: 2015 end-page: 472 ident: CR52 article-title: Evolving synergistic combinations of targeted immunotherapies to combat cancer publication-title: Nat. Rev. Cancer doi: 10.1038/nrc3973 – volume: 222 start-page: 155 year: 2008 end-page: 161 ident: CR10 article-title: The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance publication-title: Immunol. Rev. doi: 10.1111/j.1600-065X.2008.00607.x – volume: 27 start-page: 2897 year: 2008 end-page: 2909 ident: CR67 article-title: Glioblastoma-derived stem cell-enriched cultures form distinct subgroups according to molecular and phenotypic criteria publication-title: Oncogene doi: 10.1038/sj.onc.1210949 – volume: 11 start-page: 69 year: 2007 end-page: 82 ident: CR19 article-title: A perivascular niche for brain tumor stem cells publication-title: Cancer Cell doi: 10.1016/j.ccr.2006.11.020 – volume: 189 start-page: 444 year: 2012 end-page: 453 ident: CR11 article-title: Tumor-associated microglia/macrophages enhance the invasion of glioma stem-like cells via TGF-beta1 signaling pathway publication-title: J. Immunol. doi: 10.4049/jimmunol.1103248 – volume: 15 start-page: 501 year: 2009 end-page: 513 ident: CR20 article-title: Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells publication-title: Cancer Cell doi: 10.1016/j.ccr.2009.03.018 – volume: 84 start-page: 1926 year: 1992 end-page: 1931 ident: CR43 article-title: Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme publication-title: J. Natl Cancer Inst. doi: 10.1093/jnci/84.24.1926 – volume: 41 start-page: 49 year: 2014 end-page: 61 ident: CR51 article-title: Tumor-associated macrophages: from mechanisms to therapy publication-title: Immunity doi: 10.1016/j.immuni.2014.06.010 – volume: 8 start-page: 482 year: 2011 end-page: 485 ident: CR3 article-title: Deadly teamwork: neural cancer stem cells and the tumor microenvironment publication-title: Cell Stem Cell doi: 10.1016/j.stem.2011.04.013 – volume: 12 start-page: 1113 year: 2010 end-page: 1125 ident: CR18 article-title: Glioma cancer stem cells induce immunosuppressive macrophages/microglia publication-title: Neuro Oncol. doi: 10.1093/neuonc/noq082 – volume: 14 start-page: 368 year: 2007 end-page: 377 ident: CR47 article-title: Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival publication-title: Cell Death Differ. doi: 10.1038/sj.cdd.4402011 – volume: 82 start-page: 12 year: 1999 end-page: 16 ident: CR16 article-title: Microglial/macrophage expression of interleukin 10 in human glioblastomas publication-title: Int. J. Cancer doi: 10.1002/(SICI)1097-0215(19990702)82:1<12::AID-IJC3>3.0.CO;2-O – volume: 34 start-page: 558 year: 2015 end-page: 567 ident: CR45 article-title: EphA2 promotes infiltrative invasion of glioma stem cells through cross-talk with Akt and regulates stem cell properties publication-title: Oncogene doi: 10.1038/onc.2013.590 – volume: 33 start-page: 2236 year: 2014 end-page: 2244 ident: CR62 article-title: The pleiotrophin-ALK axis is required for tumorigenicity of glioblastoma stem cells publication-title: Oncogene doi: 10.1038/onc.2013.168 – volume: 106 start-page: dju16 year: 2014 ident: CR12 article-title: Effect of miR-142-3p on the M2 macrophage and therapeutic efficacy against murine glioblastoma publication-title: J. Natl Cancer Inst. doi: 10.1093/jnci/dju162 – volume: 27 start-page: 462 year: 2015 end-page: 472 ident: CR56 article-title: Macrophages and therapeutic resistance in cancer publication-title: Cancer Cell doi: 10.1016/j.ccell.2015.02.015 – volume: 580 start-page: 4051 year: 2006 end-page: 4056 ident: CR63 article-title: Protein tyrosine phosphatase receptor type Z is inactivated by ligand-induced oligomerization publication-title: FEBS Lett. doi: 10.1016/j.febslet.2006.06.041 – volume: 23 start-page: 549 year: 2002 end-page: 555 ident: CR9 article-title: Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes publication-title: Trends Immunol. doi: 10.1016/S1471-4906(02)02302-5 – volume: 280 start-page: 26953 year: 2005 end-page: 26964 ident: CR57 article-title: Differential induction of glioblastoma migration and growth by two forms of pleiotrophin publication-title: J. Biol. Chem. doi: 10.1074/jbc.M502614200 – volume: 22 start-page: 1219 year: 2015 end-page: 1226 ident: CR49 article-title: Molecular subtypes, stem cells and heterogeneity: Implications for personalised therapy in glioma publication-title: J. Clin. Neurosci. doi: 10.1016/j.jocn.2015.02.008 – volume: 8 start-page: ra125 year: 2015 ident: CR61 article-title: Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas publication-title: Sci. Signal doi: 10.1126/scisignal.aaa1690 – volume: 216 start-page: 15 year: 2008 end-page: 24 ident: CR39 article-title: Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas publication-title: J. Pathol. doi: 10.1002/path.2370 – volume: 2 start-page: 192 year: 2012 ident: CR58 article-title: ALK receptor activation, ligands and therapeutic targeting in glioblastoma and in other cancers publication-title: Front. Oncol. doi: 10.3389/fonc.2012.00192 – volume: 279 start-page: 328 year: 1979 end-page: 331 ident: CR37 article-title: activation of a human macrophage-like cell line publication-title: Nature doi: 10.1038/279328a0 – volume: 19 start-page: 498 year: 2011 end-page: 511 ident: CR40 article-title: Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3 publication-title: Cancer Cell doi: 10.1016/j.ccr.2011.03.004 – volume: 19 start-page: 3776 year: 2013 end-page: 3786 ident: CR6 article-title: Glioma grade is associated with the accumulation and activity of cells bearing M2 monocyte markers publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-12-1940 – volume: 397 start-page: 162 year: 2002 end-page: 171 ident: CR29 article-title: Pleiotrophin: a cytokine with diverse functions and a novel signaling pathway publication-title: Arch. Biochem. Biophys. doi: 10.1006/abbi.2001.2705 – volume: 16 start-page: 1421 year: 2015 end-page: 1425 ident: CR27 article-title: Serum pleiotrophin could be an early indicator for diagnosis and prognosis of non-small cell lung cancer publication-title: Asian Pac. J. Cancer Prev. doi: 10.7314/APJCP.2015.16.4.1421 – volume: 33 start-page: D169 year: 2005 end-page: D173 ident: CR36 article-title: SPD—a web-based secreted protein database publication-title: Nucleic Acids Res. doi: 10.1093/nar/gki093 – volume: 12 start-page: 537 year: 2012 ident: CR32 article-title: PTPRZ1 regulates calmodulin phosphorylation and tumor progression in small-cell lung carcinoma publication-title: BMC Cancer doi: 10.1186/1471-2407-12-537 – volume: 284 start-page: 699 year: 2011 end-page: 704 ident: CR33 article-title: Significance of PTPRZ1 and CIN85 expression in cervical carcinoma publication-title: Arch. Gynecol. Obstet. doi: 10.1007/s00404-010-1693-9 – volume: 97 start-page: 2603 year: 2000 end-page: 2608 ident: CR28 article-title: Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.020487997 – volume: 79–80 start-page: 172 year: 2014 end-page: 183 ident: CR2 article-title: Engineering strategies to mimic the glioblastoma microenvironment publication-title: Adv Drug Deliv. Rev. doi: 10.1016/j.addr.2014.08.012 – volume: 121 start-page: 37 year: 1995 end-page: 51 ident: CR23 article-title: Expression of the heparin-binding cytokines, midkine (MK) and HB-GAM (pleiotrophin) is associated with epithelial-mesenchymal interactions during fetal development and organogenesis publication-title: Development – volume: 10 start-page: 459 year: 2009 end-page: 466 ident: CR1 article-title: Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial publication-title: Lancet Oncol. doi: 10.1016/S1470-2045(09)70025-7 – volume: 74 start-page: 2698 year: 2014 end-page: 2709 ident: CR50 article-title: Cancer stem-like cells derived from chemoresistant tumors have a unique capacity to prime tumorigenic myeloid cells publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-13-2169 – volume: 24 start-page: 167 year: 2017 end-page: 180 ident: CR64 article-title: Tetraspanin CD9 stabilizes gp130 by preventing its ubiquitin-dependent lysosomal degradation to promote STAT3 activation in glioma stem cells publication-title: Cell Death Differ. doi: 10.1038/cdd.2016.110 – volume: 11 start-page: 145 year: 2009 end-page: 156 ident: CR55 article-title: Enhanced antitumorigenic effects in glioblastoma on double targeting of pleiotrophin and its receptor ALK publication-title: Neoplasia doi: 10.1593/neo.81040 – volume: 55 start-page: 141 year: 2001 ident: BFncomms15080_CR22 publication-title: J. Neurooncol. doi: 10.1023/A:1013805915224 – volume: 84 start-page: 1926 year: 1992 ident: BFncomms15080_CR43 publication-title: J. Natl Cancer Inst. doi: 10.1093/jnci/84.24.1926 – volume: 110 start-page: 287 year: 2007 ident: BFncomms15080_CR54 publication-title: Blood doi: 10.1182/blood-2006-08-042374 – volume: 20 start-page: 3246 year: 2004 ident: BFncomms15080_CR69 publication-title: Bioinformatics doi: 10.1093/bioinformatics/bth349 – volume: 74 start-page: 2698 year: 2014 ident: BFncomms15080_CR50 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-13-2169 – volume: 397 start-page: 162 year: 2002 ident: BFncomms15080_CR29 publication-title: Arch. Biochem. Biophys. doi: 10.1006/abbi.2001.2705 – volume: 157 start-page: 580 year: 2014 ident: BFncomms15080_CR68 publication-title: Cell doi: 10.1016/j.cell.2014.02.030 – volume: 15 start-page: 457 year: 2015 ident: BFncomms15080_CR52 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc3973 – volume: 21 start-page: 4004 year: 2015 ident: BFncomms15080_CR65 publication-title: Clin Cancer Res. doi: 10.1158/1078-0432.CCR-14-2807 – volume: 106 start-page: dju16 year: 2014 ident: BFncomms15080_CR12 publication-title: J. Natl Cancer Inst. doi: 10.1093/jnci/dju162 – volume: 19 start-page: 1264 year: 2013 ident: BFncomms15080_CR14 publication-title: Nat. Med. doi: 10.1038/nm.3337 – volume: 62 start-page: 1265 year: 2003 ident: BFncomms15080_CR34 publication-title: J. Neuropathol. Exp. Neurol. doi: 10.1093/jnen/62.12.1265 – volume: 216 start-page: 15 year: 2008 ident: BFncomms15080_CR39 publication-title: J. Pathol. doi: 10.1002/path.2370 – volume: 12 start-page: 1113 year: 2010 ident: BFncomms15080_CR18 publication-title: Neuro Oncol. doi: 10.1093/neuonc/noq082 – volume: 11 start-page: 69 year: 2007 ident: BFncomms15080_CR19 publication-title: Cancer Cell doi: 10.1016/j.ccr.2006.11.020 – volume: 8 start-page: 482 year: 2011 ident: BFncomms15080_CR3 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2011.04.013 – volume: 280 start-page: 26953 year: 2005 ident: BFncomms15080_CR57 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M502614200 – volume: 82 start-page: 12 year: 1999 ident: BFncomms15080_CR16 publication-title: Int. J. Cancer doi: 10.1002/(SICI)1097-0215(19990702)82:1<12::AID-IJC3>3.0.CO;2-O – volume: 284 start-page: 699 year: 2011 ident: BFncomms15080_CR33 publication-title: Arch. Gynecol. Obstet. doi: 10.1007/s00404-010-1693-9 – volume: 104 start-page: 10888 year: 2007 ident: BFncomms15080_CR26 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0704366104 – volume: 15 start-page: 1079 year: 2013 ident: BFncomms15080_CR7 publication-title: Neuro Oncol. doi: 10.1093/neuonc/not082 – volume: 36 start-page: 229 year: 2015 ident: BFncomms15080_CR8 publication-title: Trends Immunol. doi: 10.1016/j.it.2015.02.004 – volume: 10 start-page: 7252 year: 2004 ident: BFncomms15080_CR70 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-04-0713 – volume: 81 start-page: 160 year: 2012 ident: BFncomms15080_CR24 publication-title: Kidney Int. doi: 10.1038/ki.2011.305 – volume: 68 start-page: 7090 year: 2008 ident: BFncomms15080_CR38 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-08-0643 – volume: 27 start-page: 462 year: 2015 ident: BFncomms15080_CR56 publication-title: Cancer Cell doi: 10.1016/j.ccell.2015.02.015 – volume: 23 start-page: 549 year: 2002 ident: BFncomms15080_CR9 publication-title: Trends Immunol. doi: 10.1016/S1471-4906(02)02302-5 – volume: 98 start-page: 6593 year: 2001 ident: BFncomms15080_CR30 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.041608698 – volume: 153 start-page: 139 year: 2013 ident: BFncomms15080_CR41 publication-title: Cell doi: 10.1016/j.cell.2013.02.021 – volume: 8 start-page: ra125 year: 2015 ident: BFncomms15080_CR61 publication-title: Sci. Signal doi: 10.1126/scisignal.aaa1690 – volume: 15 start-page: 501 year: 2009 ident: BFncomms15080_CR20 publication-title: Cancer Cell doi: 10.1016/j.ccr.2009.03.018 – volume: 79–80 start-page: 172 year: 2014 ident: BFncomms15080_CR2 publication-title: Adv Drug Deliv. Rev. doi: 10.1016/j.addr.2014.08.012 – volume: 17 start-page: 170 year: 2015 ident: BFncomms15080_CR13 publication-title: Nat. Cell Biol. doi: 10.1038/ncb3090 – volume: 444 start-page: 756 year: 2006 ident: BFncomms15080_CR21 publication-title: Nature doi: 10.1038/nature05236 – volume: 332 start-page: 664 year: 2005 ident: BFncomms15080_CR31 publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2005.05.007 – volume: 189 start-page: 444 year: 2012 ident: BFncomms15080_CR11 publication-title: J. Immunol. doi: 10.4049/jimmunol.1103248 – volume: 110 start-page: 6829 year: 2013 ident: BFncomms15080_CR46 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1217002110 – volume: 121 start-page: 37 year: 1995 ident: BFncomms15080_CR23 publication-title: Development doi: 10.1242/dev.121.1.37 – volume: 19 start-page: 498 year: 2011 ident: BFncomms15080_CR40 publication-title: Cancer Cell doi: 10.1016/j.ccr.2011.03.004 – volume: 34 start-page: 1407 year: 2015 ident: BFncomms15080_CR42 publication-title: Oncogene doi: 10.1038/onc.2014.75 – volume: 16 start-page: 475 year: 2010 ident: BFncomms15080_CR60 publication-title: Nat. Med. doi: 10.1038/nm.2119 – volume: 14 start-page: 368 year: 2007 ident: BFncomms15080_CR47 publication-title: Cell Death Differ. doi: 10.1038/sj.cdd.4402011 – volume: 19 start-page: 1207 year: 2013 ident: BFncomms15080_CR4 publication-title: Nat. Med. doi: 10.1038/nm.3355 – volume: 16 start-page: 1421 year: 2015 ident: BFncomms15080_CR27 publication-title: Asian Pac. J. Cancer Prev. doi: 10.7314/APJCP.2015.16.4.1421 – volume: 38 start-page: 19 year: 2000 ident: BFncomms15080_CR35 publication-title: Folia Histochem. Cytobiol. – volume: 22 start-page: 1219 year: 2015 ident: BFncomms15080_CR49 publication-title: J. Clin. Neurosci. doi: 10.1016/j.jocn.2015.02.008 – volume: 27 start-page: 2897 year: 2008 ident: BFncomms15080_CR67 publication-title: Oncogene doi: 10.1038/sj.onc.1210949 – volume: 147 start-page: 1393 year: 2014 ident: BFncomms15080_CR15 publication-title: Gastroenterology doi: 10.1053/j.gastro.2014.08.039 – volume: 34 start-page: 558 year: 2015 ident: BFncomms15080_CR45 publication-title: Oncogene doi: 10.1038/onc.2013.590 – volume: 2 start-page: 192 year: 2012 ident: BFncomms15080_CR58 publication-title: Front. Oncol. doi: 10.3389/fonc.2012.00192 – volume: 222 start-page: 155 year: 2008 ident: BFncomms15080_CR10 publication-title: Immunol. Rev. doi: 10.1111/j.1600-065X.2008.00607.x – volume: 33 start-page: D169 year: 2005 ident: BFncomms15080_CR36 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gki093 – volume: 19 start-page: 3776 year: 2013 ident: BFncomms15080_CR6 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-12-1940 – volume: 41 start-page: 49 year: 2014 ident: BFncomms15080_CR51 publication-title: Immunity doi: 10.1016/j.immuni.2014.06.010 – volume: 14 start-page: 5304 year: 2015 ident: BFncomms15080_CR48 publication-title: Genet. Mol. Res. doi: 10.4238/2015.May.18.23 – volume: 65 start-page: 683 year: 2016 ident: BFncomms15080_CR59 publication-title: Gut doi: 10.1136/gutjnl-2014-308176 – volume: 10 start-page: 459 year: 2009 ident: BFncomms15080_CR1 publication-title: Lancet Oncol. doi: 10.1016/S1470-2045(09)70025-7 – volume: 20 start-page: 180 year: 2009 ident: BFncomms15080_CR25 publication-title: Eur. Cytokine Netw. doi: 10.1684/ecn.2009.0172 – volume: 279 start-page: 328 year: 1979 ident: BFncomms15080_CR37 publication-title: Nature doi: 10.1038/279328a0 – volume: 12 start-page: 537 year: 2012 ident: BFncomms15080_CR32 publication-title: BMC Cancer doi: 10.1186/1471-2407-12-537 – volume: 580 start-page: 4051 year: 2006 ident: BFncomms15080_CR63 publication-title: FEBS Lett. doi: 10.1016/j.febslet.2006.06.041 – volume: 11 start-page: 145 year: 2009 ident: BFncomms15080_CR55 publication-title: Neoplasia doi: 10.1593/neo.81040 – volume: 97 start-page: 2603 year: 2000 ident: BFncomms15080_CR28 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.020487997 – volume: 6 start-page: 133 year: 2016 ident: BFncomms15080_CR53 publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-15-0583 – volume: 347 start-page: 70 year: 2009 ident: BFncomms15080_CR66 publication-title: J. Immunol. Methods doi: 10.1016/j.jim.2009.06.008 – volume: 25 start-page: 3029 year: 2007 ident: BFncomms15080_CR44 publication-title: Stem Cells doi: 10.1634/stemcells.2007-0372 – volume: 19 start-page: 20 year: 2015 ident: BFncomms15080_CR5 publication-title: Nat. Neurosci. doi: 10.1038/nn.4185 – volume: 6 start-page: 723 year: 2014 ident: BFncomms15080_CR17 publication-title: Cancers doi: 10.3390/cancers6020723 – volume: 33 start-page: 2236 year: 2014 ident: BFncomms15080_CR62 publication-title: Oncogene doi: 10.1038/onc.2013.168 – volume: 24 start-page: 167 year: 2017 ident: BFncomms15080_CR64 publication-title: Cell Death Differ. doi: 10.1038/cdd.2016.110 – reference: 21881556 - Kidney Int. 2012 Jan;81(2):160-9 – reference: 20305662 - Nat Med. 2010 Apr;16(4):475-82 – reference: 26713745 - Nat Neurosci. 2016 Jan;19(1):20-7 – reference: 27740621 - Cell Death Differ. 2017 Jan;24(1):167-180 – reference: 17369488 - Blood. 2007 Jul 1;110(1):287-95 – reference: 23267434 - Front Oncol. 2012 Dec 19;2:192 – reference: 18364000 - Immunol Rev. 2008 Apr;222:155-61 – reference: 18757424 - Cancer Res. 2008 Sep 1;68(17):7090-9 – reference: 15608170 - Nucleic Acids Res. 2005 Jan 1;33(Database issue):D169-73 – reference: 24100977 - Nat Med. 2013 Oct;19(10):1207-8 – reference: 25957782 - J Clin Neurosci. 2015 Aug;22(8):1219-26 – reference: 23828240 - Neuro Oncol. 2013 Aug;15(8):1079-87 – reference: 20167557 - Eur Cytokine Netw. 2009 Dec;20(4):180-90 – reference: 25580734 - Nat Cell Biol. 2015 Feb;17(2):170-82 – reference: 26645582 - Sci Signal. 2015 Dec 08;8(406):ra125 – reference: 20882291 - Arch Gynecol Obstet. 2011 Sep;284(3):699-704 – reference: 24704830 - Oncogene. 2015 Mar 12;34(11):1407-19 – reference: 17823238 - Stem Cells. 2007 Dec;25(12):3029-37 – reference: 25181692 - Gastroenterology. 2014 Dec;147(6):1393-404 – reference: 24675569 - Cancers (Basel). 2014 Mar 26;6(2):723-40 – reference: 20667896 - Neuro Oncol. 2010 Nov;12(11):1113-25 – reference: 17051156 - Nature. 2006 Dec 7;444(7120):756-60 – reference: 22664874 - J Immunol. 2012 Jul 1;189(1):444-53 – reference: 21549324 - Cell Stem Cell. 2011 May 6;8(5):482-5 – reference: 23540695 - Cell. 2013 Mar 28;153(1):139-52 – reference: 18553315 - J Pathol. 2008 Sep;216(1):15-24 – reference: 15908427 - J Biol Chem. 2005 Jul 22;280(29):26953-64 – reference: 18037961 - Oncogene. 2008 May 1;27(20):2897-909 – reference: 23741072 - Clin Cancer Res. 2013 Jul 15;19(14):3776-86 – reference: 19269895 - Lancet Oncol. 2009 May;10 (5):459-66 – reference: 26023083 - Clin Cancer Res. 2015 Sep 1;21(17):4004-13 – reference: 24726434 - Cell. 2014 Apr 24;157(3):580-94 – reference: 26125726 - Genet Mol Res. 2015 May 18;14(2):5304-9 – reference: 25035953 - Immunity. 2014 Jul 17;41(1):49-61 – reference: 15180930 - Bioinformatics. 2004 Nov 22;20(17):3246-8 – reference: 15925565 - Biochem Biophys Res Commun. 2005 Jul 8;332(3):664-9 – reference: 16814777 - FEBS Lett. 2006 Jul 24;580(17):4051-6 – reference: 25596181 - Gut. 2016 Apr;65(4):683-92 – reference: 17222791 - Cancer Cell. 2007 Jan;11(1):69-82 – reference: 25174308 - Adv Drug Deliv Rev. 2014 Dec 15;79-80:172-83 – reference: 24974128 - J Natl Cancer Inst. 2014 Jun 28;106(8):null – reference: 10360813 - Int J Cancer. 1999 Jul 2;82(1):12-6 – reference: 23686309 - Oncogene. 2014 Apr 24;33(17):2236-44 – reference: 12401408 - Trends Immunol. 2002 Nov;23(11):549-55 – reference: 26205340 - Nat Rev Cancer. 2015 Aug;15(8):457-72 – reference: 14692702 - J Neuropathol Exp Neurol. 2003 Dec;62(12):1265-75 – reference: 21481791 - Cancer Cell. 2011 Apr 12;19(4):498-511 – reference: 16841086 - Cell Death Differ. 2007 Feb;14(2):368-77 – reference: 25858805 - Cancer Cell. 2015 Apr 13;27(4):462-72 – reference: 19177199 - Neoplasia. 2009 Feb;11(2):145-56 – reference: 25770924 - Trends Immunol. 2015 Apr;36(4):229-39 – reference: 450085 - Nature. 1979 May 24;279(5711):328-31 – reference: 19477429 - Cancer Cell. 2009 Jun 2;15(6):501-13 – reference: 10706604 - Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2603-8 – reference: 24638980 - Cancer Res. 2014 May 15;74(10):2698-709 – reference: 7867507 - Development. 1995 Jan;121(1):37-51 – reference: 23170925 - BMC Cancer. 2012 Nov 21;12:537 – reference: 24488013 - Oncogene. 2015 Jan 29;34(5):558-67 – reference: 19567251 - J Immunol Methods. 2009 Aug 15;347(1-2):70-8 – reference: 15534099 - Clin Cancer Res. 2004 Nov 1;10(21):7252-9 – reference: 17578909 - Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10888-93 – reference: 10763119 - Folia Histochem Cytobiol. 2000;38(1):19-20 – reference: 23569237 - Proc Natl Acad Sci U S A. 2013 Apr 23;110(17 ):6829-34 – reference: 26503962 - Cancer Discov. 2016 Feb;6(2):133-46 – reference: 1334154 - J Natl Cancer Inst. 1992 Dec 16;84(24):1926-31 – reference: 11381105 - Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6593-8 – reference: 25743809 - Asian Pac J Cancer Prev. 2015;16(4):1421-5 – reference: 11795867 - Arch Biochem Biophys. 2002 Jan 15;397(2):162-71 – reference: 11859968 - J Neurooncol. 2001 Dec;55(3):141-7 – reference: 24056773 - Nat Med. 2013 Oct;19(10):1264-72 |
| SSID | ssj0000391844 |
| Score | 2.6263871 |
| Snippet | Intense infiltration of tumour-associated macrophages (TAMs) facilitates malignant growth of glioblastoma (GBM), but the underlying mechanisms remain... Tumour-associated macrophages (TAMs) facilitate malignant growth of glioblastoma (GBM). Here, the authors show that TAMs support glioma stem cell renewal via... |
| SourceID | doaj pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 15080 |
| SubjectTerms | 13/1 13/31 13/51 13/89 14/19 14/5 42 631/67/1922 631/67/327 631/67/580 631/67/71 Brain cancer Humanities and Social Sciences Infiltration Medical prognosis multidisciplinary Science Science (multidisciplinary) Signal transduction Stem cells Tumors |
| SummonAdditionalLinks | – databaseName: DOAJ - Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9wwEBYlEOilNG3auk2LCsmlYCLbkmwd29AQCg0hbCD0YvQYZxd27SXWHgL98R3J3mW3CfTSo6UByzMjzzd6fEPIsVC5dSBdykDylBtdpQa4ThViDcNcJhsWLgr_vJQXN_zHrbjdKvUVzoQN9MCD4k4bmzHHDdem0hwKaxAvG8ugxNwKg3m8uocxbyuZiv_gQmHqwscLeayoTls04KIP7OdsJwRFpv6n4OXjU5J_bZXGCHT-krwYoSP9Ogz5gDyD9hXZH4pJPrwmvycrTOPvUz0qHBxd6FCga4q_jJ72AR96oMs5zDofmmct9R1dxvN4QK8mV9e_MhrOc-jI002x_24-6wzia98tNA2UzzQs9PcUkS718XX0DvN4Pz0kN-ffJ2cX6VhbIbUY4n1a2MbqqoAGKl1h1M90CQbRgC4NF9yUShiRN8CcUhZzjkYoIyRvtNNKGe1E8YbstV0L7wg1kEsjS1aClRzhGz4DA8jQyswVgifky1rdtR2Jx0P9i3kdN8CLqt6yTUKON8LLgW_jabFvwW4bkUCSHRvQderRdep_uU5CjtZWr8eZ29cIkBCjhrKaCfm86cY5F_SrW-hWg4wKxHlZQt4OTrIZSV4JGXK0hJQ77rMz1N2edjaNvN6CI1ZS-G0na0fbGtZjHbz_Hzr4QJ7nAajEdaUjsufvV_ARYZY3n-KM-gNK1izZ priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Technology Collection dbid: 8FG link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fi9QwEA56Ivgi_r6ep0Q4X4RyaZu0zZOouB6CcsgeHL6UJJ3uLuy267b7cOAf70zarbfe4WOT0KaZJPPNZPINYydKx66EtAwFpDKU1uShBWlCjVjDijJKK0EXhb99T88u5NdLdTk43NohrHK3J_qNumwc-chPUXEhdqB0h-_Xv0LKGkWnq0MKjbvsXoSahkK68smX0cdC7Oe5lMO1PJHkpzW-ctUSB7rYU0Ser_82kHkzVvKfA1OvhyaP2MMBQPIPvcQfsztQP2H3-5SSV0_Z7-kWjflNaIZhh5KvDKXpmuPG0fKWUGIHfL2ERdNR8aLmXcPXPioP-Pn0_MfPiFNUh_Fs3RzrZ8tFYxFld83KcCJ-5uTubzniXd75z_EZWvPd_Bm7mHyefjoLhwwLoUNF34WJq5zJE6ggNznq_shkYBETmMxKJW2mlVVxBaLU2qHlUSltVSorUxqtrSlV8pwd1E0Nh4xbiFObZiIDl0oEcfgMAiBCWYsyUTJg73bDXbiBfpyyYCwLfwye5MU12QTsZGy87lk3bm_2keQ2NiGqbF_QbGbFsPKKykWilFYamxsJibNocFknIEPjHNGgDtjxTurFsH7b4u9sC9ibsRpXHo2vqaHZ9m000edFAXvRT5KxJ3GuUrLUApbtTZ-9ru7X1Iu5Z_dWEhGTxn97u5to17p1cwyO_t_9l-xBTEDE-42O2UG32cIrhFGdfe3Xyh_M6yQN priority: 102 providerName: ProQuest – databaseName: Springer Nature HAS Fully OA dbid: AAJSJ link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3fa9swEBajZbCXsd9z1w0NupeBmWxLsvWYjZUS2ChbCmUvRpLPSSCxQ-w8DPbH7yQrJln7sEdLZyyfTtJ30uk7Qi6ESm0FsooZSB5zo4vYANexQqxhWJXImrmLwt--y6sbPr0Vt4FnuwthlQOlpZ-m99Fhnxp8WneOvBz981PH0Y5GfTqZTH9Oxy0VR3ZecB5u4bGsOHzraN3x9Pz3Ycq7oZH_nI_6ZefyCXkc8CKdDC18Sh5A84w8HDJI_n5O_sx26LtvYx20DBVda5eVa4HzREc7Bwp7oJsVLNveFS8b2rd044PwgF7Prn_8SqgL4tCenJti_Xy1bA2C6r5da-p4nqnb3e8owlva-8_ROTrv_eIFubn8OvtyFYeECrHFdb2PM1tbXWRQQ6ELXOoTnYNBCKBzwwU3uRJGpDWwSimLjkYtlBGS17rSShldiewlOWnaBl4TaiCVRuYsBys5YjZ8BgaQYNeyKhM8Ih_36i5tYBt3SS9WpT_1zoryoG8icjEKbwaSjfvFPrt-G0UcM7YvaLfzMlhKWduEVdxwbQrNIbMG_StjGeToiyP4UxE53_d6GYZrVyIqQmDqcmlG5P1YjQPN6Vc30O4GGeXY8pKIvBqMZGxJWgjpHLOI5Efmc9TU45pmufBk3oIjQFL4bx_2hnbQrLs6OPtPuTfkUeoAiN8vOicn_XYHbxE-9eZdGDZ_AbJmIfQ priority: 102 providerName: Springer Nature |
| Title | Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth |
| URI | https://link.springer.com/article/10.1038/ncomms15080 https://www.ncbi.nlm.nih.gov/pubmed/28569747 https://www.proquest.com/docview/1904166989 https://www.proquest.com/docview/1904902311 https://pubmed.ncbi.nlm.nih.gov/PMC5461490 https://doaj.org/article/fc10d4b4ab8a4e3cb428bc0e73382649 |
| Volume | 8 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1da9swFBVdy2AvY9_z1gUNupeBN39IlvUwRhqalUBL6BIIezGSfZ0EEjuLHVhhP35XshOaNuzFxpKM5Xsl6xxZOpeQMy6DNIMocz2ImMu0il0NTLkSsYb2Mj_KPbNR-Oo6uhyzwYRPjsg2GGdrwOogtTPxpMbrxZc_v2-_Y4f_1mwZj78W6JtlZYTNkbuf4JAkTCiDqxbn209yKJHJsHZ_3r179kYkK9x_CG0-XDR578-pHZD6z8jTFknSbuP65-QIihfkcRNb8vYl-TvaIKtfu6q1P2R0qUy8rhl-QSpaGbhYA10tYF7WJnle0LqkK7s8D-hwNLz55VOzvENZ2W6K-dPFvNQIt-tyqahRgKZm3r-iCHxpbR9Hp0jr69krMu5fjHqXbhtqwU1xxK_dMM1TFYeQQ6xiBAG-EqARHCihGWdaSK55kIOXSZkiBcm51DxiucqUlFplPHxNjouygLeEaggiHQlPQBoxRHN4DR6Aj073spAzh3zemjtJWx1yEw5jkdj_4WGc3PGNQ852hVeN_MbhYufGb7siRjPbJpTradJ2wSRPfS9jmikdKwZhqpF56dQDgSwdYaF0yOnW68m2HSaIlxCymiibDvm4y8YuaOyrCig3TRlpdPR8h7xpGsmuJkHMI0PZHCL2ms9eVfdzivnMynxzhtBJ4rt92ja0O9V6aIN3_6_-e_IkMIjETiCdkuN6vYEPiKdq3SGPxETgMe7_6JCTbnfwc4Dn84vr4Q2m9qJex85UdGyf-gc_Ni2r |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Zb9QwELaqIgQviJtAASO1L0hRcziHHxDiWrb0UIW2UsVLaieT3ZV2k2WTVVWJ38RvZMY56NKKtz7GHim2Zzzz-ZqPse1AemkGYWY7EApbaBXbGoSyJWIN7WRumDv0UPjwKByeiG-nwekG-929haFrlZ1PNI46K1PaI9_FwIXYgegO3y9-2sQaRaerHYVGYxb7cHGOS7bq3d5n1O-O5w2-jD4N7ZZVwE4xuNW2n-apin3IIVYxxjtXRaAxDqpIi0DoSAY68HJwMilTRNt5IHUQilxlSkqtMmKJQJd_S_gYyell-uBrv6dD2dZjIdpngI4f7xbYhXlFOdedtcBn-AGuA7VX72b-c0Br4t7gPrvXAlb-obGwB2wDiofsdkNhefGI_Rqt5ihiq1bNkPG5IlqwCTqqileESmvgixlMy5qKpwWvS74wtwCBH4-Ov_9wOd0iUSY7OMf68WxaakT1dTlXnBJNczpeqDjia16b3_HxsjyvJ4_ZyY2M_RO2WZQFPGNcgxfqMHIiSEOBoBG_wQFw0baczA-Exd52w52kbbpzYt2YJebY3Y-TS7qx2HYvvGiyfFwv9pH01otQam5TUC7HSTvTkzx1nUxooXSsBPipxgWeTh2IfB-XckJabKvTetL6iyr5a90We9NX40yn8VUFlKtGRlK6PtdiTxsj6VvixUFIK0OLRWvms9bU9ZpiOjHZxAOBCE1i33Y6Q7vUrKtj8Pz_zX_N7gxHhwfJwd7R_gt21yMQZPastthmvVzBS4RwtX5l5g1nZzc9Uf8A7XNiXw |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF5VqUBcEO8aCixSe0GysrbXrwNClDZqKURRlUoVF7Nrj5NIiR1iR1Ulfhm_jhm_aGjFrUd7R_J65_XN7uwMY3tuaMcJeIkpwJOm1CowNUhlhog1tEgsLxV0Ufjb0Ds-l18u3Ist9ru9C0Npla1NrAx1kse0R95Hx4XYgdod9tMmLWJ0OPi4_GlSByk6aW3badQicgpXlxi-FR9ODpHX-7Y9OBp_PjabDgNmjI6uNJ04jVXgQAqBCtD3WcoHjT5R-Vq6Uvuhq107BZGEYYzIO3VD7XoyVYkKQ60S6hiB5n_bp6iox7YPjoajs26Hh2qvB1I2lwKFE_Qz_KFFQRXYxYYbrLoF3AZxb2Zq_nNcW3nBwSP2sIGv_FMtb4_ZFmRP2L26oeXVU_ZrvF4giakapkPCF4qahE3RbBW8IIxaAl_OYZaX9HqW8TLnyyonEPhoPDr7bnHKKVFVrXCO45P5LNeI8ct8oTiVneZ02FBwRNu8rD7HJ6v8spw-Y-d3svrPWS_LM9hhXIPtac8XPsSeRAiJzyAALJQ0kTiuNNj7drmjuCl-Tj045lF1CO8E0TXeGGyvI17WNT9uJzsgvnUkVKi7epGvJlGj91EaWyKRWiodKAlOrDHc07EA33EwsJOhwXZbrkeN9Siiv7JusHfdMOo9ra_KIF_XNCEV77MM9qIWkm4mduB6FCcazN8Qn42pbo5ks2lVW9yViNdC_Lf9VtCuTevmGrz8__TfsvuopNHXk-HpK_bAJkRUbWDtsl65WsNrxHOlftMoDmc_7lpX_wDORmfx |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Tumour-associated+macrophages+secrete+pleiotrophin+to+promote+PTPRZ1+signalling+in+glioblastoma+stem+cells+for+tumour+growth&rft.jtitle=Nature+communications&rft.au=Shi%2C+Yu&rft.au=Ping%2C+Yi-fang&rft.au=Zhou%2C+Wenchao&rft.au=He%2C+Zhi-cheng&rft.date=2017-06-01&rft.pub=Nature+Publishing+Group&rft.eissn=2041-1723&rft.volume=8&rft.spage=15080&rft_id=info:doi/10.1038%2Fncomms15080&rft.externalDBID=HAS_PDF_LINK&rft.externalDocID=4322636355 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon |