The regulation of lymphocyte activation and proliferation

• Published in: Current opinion in immunology Vol. 51; pp. 32 - 38
• Main Authors: Heinzel, Susanne, Marchingo, Julia M, Horton, Miles B, Hodgkin, Philip D
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2018
• Subjects: Animals; Cell Differentiation - genetics; Cell Differentiation - immunology; Cell Survival; Clonal Evolution - genetics; Clonal Evolution - immunology; Clonal Selection, Antigen-Mediated - genetics; Clonal Selection, Antigen-Mediated - immunology; Gene Expression Regulation, Developmental; Humans; Immunity; Lymphocyte Activation - genetics; Lymphocyte Activation - immunology; Lymphocytes - cytology; Lymphocytes - immunology; Lymphocytes - metabolism; Signal Transduction

•Activation induces a programmed timed division burst before return to quiescence.•Clonal integration of activation signals, stochastic probabilities and ongoing signals.•Signals are integrated by each cell in a cumulative manner.•Clonal inheritance and interclonal variation shape the response. Acti...