Short-term plasticity of the motor cortex compensates for bradykinesia in Parkinson’s disease

• Published in: Neurobiology of disease Vol. 182; p. 106137
• Main Authors: Guerra, Andrea, Colella, Donato, Cannavacciuolo, Antonio, Giangrosso, Margherita, Paparella, Giulia, Fabbrini, Giovanni, Berardelli, Alfredo, Bologna, Matteo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.06.2023; Elsevier
• Subjects: beta oscillations; bradykinesia; GABA; motor cortex; Parkinson's disease; Short-term potentiation; GABA; Short-term potentiation; motor cortex; Parkinson's disease; bradykinesia; beta oscillations

Patients with Parkinson's disease (PD) show impaired short-term potentiation (STP) mechanisms in the primary motor cortex (M1). However, the role played by this neurophysiological abnormality in bradykinesia pathophysiology is unknown. In this study, we used a multimodal neuromodulation approac...