Radiation and immune checkpoint inhibitor-mediated pneumonitis risk stratification in patients with locally advanced non-small cell lung cancer: role of functional lung radiomics?

• Published in: Discover. Oncology Vol. 13; no. 1; pp. 85 - 12
• Main Authors: Thomas, Hannah M. T., Hippe, Daniel S., Forouzannezhad, Parisa, Sasidharan, Balu Krishna, Kinahan, Paul E., Miyaoka, Robert S., Vesselle, Hubert J., Rengan, Ramesh, Zeng, Jing, Bowen, Stephen R.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.09.2022; Springer
• Subjects: Cancer Research; Functional lung imaging; Immunotherapy; Internal Medicine; Medicine; Medicine & Public Health; Molecular Medicine; Oncology; Pneumonitis; Radiation therapy; Radiomics; Radiotherapy; SPECT; Surgical Oncology; Pneumonitis; Immunotherapy; Machine learning; Radiation therapy; Functional lung imaging; SPECT; Radiomics

Background Patients undergoing chemoradiation and immune checkpoint inhibitor (ICI) therapy for locally advanced non-small cell lung cancer (NSCLC) experience pulmonary toxicity at higher rates than historical reports. Identifying biomarkers beyond conventional clinical factors and radiation dosimet...