A microRNA-initiated DNAzyme motor operating in living cells

• Published in: Nature communications Vol. 8; no. 1; pp. 14378 - 13
• Main Authors: Peng, Hanyong, Li, Xing-Fang, Zhang, Hongquan, Le, X. Chris
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.03.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 14; 14/10; 631/337/384/331; 639/638/11/942; 639/925/926/1048; Cations, Divalent; Deoxyribonucleic acid; DNA; DNA - genetics; DNA - metabolism; DNA, Catalytic - genetics; DNA, Catalytic - metabolism; Gold - chemistry; Humanities and Social Sciences; Humans; Kinetics; Manganese - chemistry; Manganese - metabolism; MCF-7 Cells; Metal Nanoparticles - chemistry; MicroRNAs; MicroRNAs - analysis; MicroRNAs - genetics; MicroRNAs - metabolism; Molecular Motor Proteins - genetics; Molecular Motor Proteins - metabolism; multidisciplinary; Proteins; Science; Science (multidisciplinary); Single-Cell Analysis - methods

Synthetic DNA motors have great potential to mimic natural protein motors in cells but the operation of synthetic DNA motors in living cells remains challenging and has not been demonstrated. Here we report a DNAzyme motor that operates in living cells in response to a specific intracellular target....