A microRNA-initiated DNAzyme motor operating in living cells

Synthetic DNA motors have great potential to mimic natural protein motors in cells but the operation of synthetic DNA motors in living cells remains challenging and has not been demonstrated. Here we report a DNAzyme motor that operates in living cells in response to a specific intracellular target....

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Published in	Nature communications Vol. 8; no. 1; pp. 14378 - 13
Main Authors	Peng, Hanyong, Li, Xing-Fang, Zhang, Hongquan, Le, X. Chris
Format	Journal Article
Language	English
Published	London Nature Publishing Group UK 06.03.2017 Nature Publishing Group Nature Portfolio
Subjects	14 14/10 631/337/384/331 639/638/11/942 639/925/926/1048 Cations, Divalent Deoxyribonucleic acid DNA DNA - genetics DNA - metabolism DNA, Catalytic - genetics DNA, Catalytic - metabolism Gold - chemistry Humanities and Social Sciences Humans Kinetics Manganese - chemistry Manganese - metabolism MCF-7 Cells Metal Nanoparticles - chemistry MicroRNAs MicroRNAs - analysis MicroRNAs - genetics MicroRNAs - metabolism Molecular Motor Proteins - genetics Molecular Motor Proteins - metabolism multidisciplinary Proteins Science Science (multidisciplinary) Single-Cell Analysis - methods
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Abstract	Synthetic DNA motors have great potential to mimic natural protein motors in cells but the operation of synthetic DNA motors in living cells remains challenging and has not been demonstrated. Here we report a DNAzyme motor that operates in living cells in response to a specific intracellular target. The whole motor system is constructed on a 20 nm gold nanoparticle (AuNP) decorated with hundreds of substrate strands serving as DNA tracks and dozens of DNAzyme molecules each silenced by a locking strand. Intracellular interaction of a target molecule with the motor system initiates the autonomous walking of the motor on the AuNP. An example DNAzyme motor responsive to a specific microRNA enables amplified detection of the specific microRNA in individual cancer cells. Activated by specific intracellular targets, these self-powered DNAzyme motors will have diverse applications in the control and modulation of biological functions. Synthetic DNA nanomachines have been designed to perform a variety of tasks in vitro . Here, the authors build a nanomotor system that integrates a DNAzyme and DNA track on a gold nanoparticle, to facilitate cellular uptake, and apply it as a real-time miRNA imaging tool in living cells.
AbstractList	Synthetic DNA motors have great potential to mimic natural protein motors in cells but the operation of synthetic DNA motors in living cells remains challenging and has not been demonstrated. Here we report a DNAzyme motor that operates in living cells in response to a specific intracellular target. The whole motor system is constructed on a 20 nm gold nanoparticle (AuNP) decorated with hundreds of substrate strands serving as DNA tracks and dozens of DNAzyme molecules each silenced by a locking strand. Intracellular interaction of a target molecule with the motor system initiates the autonomous walking of the motor on the AuNP. An example DNAzyme motor responsive to a specific microRNA enables amplified detection of the specific microRNA in individual cancer cells. Activated by specific intracellular targets, these self-powered DNAzyme motors will have diverse applications in the control and modulation of biological functions. Synthetic DNA nanomachines have been designed to perform a variety of tasksin vitro. Here, the authors build a nanomotor system that integrates a DNAzyme and DNA track on a gold nanoparticle, to facilitate cellular uptake, and apply it as a real-time miRNA imaging tool in living cells. Synthetic DNA motors have great potential to mimic natural protein motors in cells but the operation of synthetic DNA motors in living cells remains challenging and has not been demonstrated. Here we report a DNAzyme motor that operates in living cells in response to a specific intracellular target. The whole motor system is constructed on a 20 nm gold nanoparticle (AuNP) decorated with hundreds of substrate strands serving as DNA tracks and dozens of DNAzyme molecules each silenced by a locking strand. Intracellular interaction of a target molecule with the motor system initiates the autonomous walking of the motor on the AuNP. An example DNAzyme motor responsive to a specific microRNA enables amplified detection of the specific microRNA in individual cancer cells. Activated by specific intracellular targets, these self-powered DNAzyme motors will have diverse applications in the control and modulation of biological functions. Synthetic DNA nanomachines have been designed to perform a variety of tasks in vitro . Here, the authors build a nanomotor system that integrates a DNAzyme and DNA track on a gold nanoparticle, to facilitate cellular uptake, and apply it as a real-time miRNA imaging tool in living cells. Synthetic DNA motors have great potential to mimic natural protein motors in cells but the operation of synthetic DNA motors in living cells remains challenging and has not been demonstrated. Here we report a DNAzyme motor that operates in living cells in response to a specific intracellular target. The whole motor system is constructed on a 20 nm gold nanoparticle (AuNP) decorated with hundreds of substrate strands serving as DNA tracks and dozens of DNAzyme molecules each silenced by a locking strand. Intracellular interaction of a target molecule with the motor system initiates the autonomous walking of the motor on the AuNP. An example DNAzyme motor responsive to a specific microRNA enables amplified detection of the specific microRNA in individual cancer cells. Activated by specific intracellular targets, these self-powered DNAzyme motors will have diverse applications in the control and modulation of biological functions.Synthetic DNA motors have great potential to mimic natural protein motors in cells but the operation of synthetic DNA motors in living cells remains challenging and has not been demonstrated. Here we report a DNAzyme motor that operates in living cells in response to a specific intracellular target. The whole motor system is constructed on a 20 nm gold nanoparticle (AuNP) decorated with hundreds of substrate strands serving as DNA tracks and dozens of DNAzyme molecules each silenced by a locking strand. Intracellular interaction of a target molecule with the motor system initiates the autonomous walking of the motor on the AuNP. An example DNAzyme motor responsive to a specific microRNA enables amplified detection of the specific microRNA in individual cancer cells. Activated by specific intracellular targets, these self-powered DNAzyme motors will have diverse applications in the control and modulation of biological functions.
ArticleNumber	14378
Author	Li, Xing-Fang Peng, Hanyong Le, X. Chris Zhang, Hongquan
Author_xml	– sequence: 1 givenname: Hanyong surname: Peng fullname: Peng, Hanyong organization: Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta – sequence: 2 givenname: Xing-Fang orcidid: 0000-0003-1844-7700 surname: Li fullname: Li, Xing-Fang organization: Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta – sequence: 3 givenname: Hongquan surname: Zhang fullname: Zhang, Hongquan email: hongquan@ualberta.ca organization: Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta – sequence: 4 givenname: X. Chris surname: Le fullname: Le, X. Chris email: xc.le@ualberta.ca organization: Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/28262725$$D View this record in MEDLINE/PubMed
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Snippet	Synthetic DNA motors have great potential to mimic natural protein motors in cells but the operation of synthetic DNA motors in living cells remains... Synthetic DNA nanomachines have been designed to perform a variety of tasksin vitro. Here, the authors build a nanomotor system that integrates a DNAzyme and...
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SubjectTerms	14 14/10 631/337/384/331 639/638/11/942 639/925/926/1048 Cations, Divalent Deoxyribonucleic acid DNA DNA - genetics DNA - metabolism DNA, Catalytic - genetics DNA, Catalytic - metabolism Gold - chemistry Humanities and Social Sciences Humans Kinetics Manganese - chemistry Manganese - metabolism MCF-7 Cells Metal Nanoparticles - chemistry MicroRNAs MicroRNAs - analysis MicroRNAs - genetics MicroRNAs - metabolism Molecular Motor Proteins - genetics Molecular Motor Proteins - metabolism multidisciplinary Proteins Science Science (multidisciplinary) Single-Cell Analysis - methods
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Title	A microRNA-initiated DNAzyme motor operating in living cells
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