Multimodal quantitative magnetic resonance imaging for lumbar intervertebral disc degeneration
The present study investigated the application of the T1ρ and T2 relaxation mapping magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) in the evaluation of intervertebral disc degeneration (IDD). A total of 93 asymptomatic subjects were imaged with T1ρ and T2 mapping, as well as D...
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| Published in | Experimental and therapeutic medicine Vol. 14; no. 3; pp. 2078 - 2084 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Greece
D.A. Spandidos
01.09.2017
Spandidos Publications Spandidos Publications UK Ltd |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1792-0981 1792-1015 |
| DOI | 10.3892/etm.2017.4786 |
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| Abstract | The present study investigated the application of the T1ρ and T2 relaxation mapping magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) in the evaluation of intervertebral disc degeneration (IDD). A total of 93 asymptomatic subjects were imaged with T1ρ and T2 mapping, as well as DWI. Pfirrmann grading was performed and correlation analysis was conducted for T1ρ, T2 and DWI results with the grading results and age. Pfirrmann grading indicated 69 cases of grade I, 240 cases of grade II, 101 cases of grade III, 43 cases of grade IV and 12 cases of grade V. MRI showed that the T1ρ values of the nucleus pulposi at L4/5 and L5/S1 were significantly reduced (P<0.05) and no significant differences were observed in the T2 values compared with the values of the nucleus pulposus at L1/2, L2/3 and L3/4. The apparent diffusion coefficient (ADC) values of L1/2 were significantly decreased from L2/3 and L3/4 (P<0.05). Correlation analysis revealed that the T1ρ, T, and ADC values were positively correlated with each other. Moreover, the T1ρvalues were significantly decreased with the increase of Pfirrmann grades (P<0.05), with the exception of grades IV and V. However, T2 and ADC values were not significantly different between grades I and II or IV and V. In addition, the T1ρ, T2 and ADC values were significantly decreased with the increase of age in patients with IDD (P<0.05). T1ρ and T2 mapping and DWI are promising techniques for the in vivo diagnosis of IDD, which may be useful in determining the appropriate prevention and treatment options for the disease. |
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| AbstractList | The present study investigated the application of the T
and T
relaxation mapping magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) in the evaluation of intervertebral disc degeneration (IDD). A total of 93 asymptomatic subjects were imaged with T
and T
mapping, as well as DWI. Pfirrmann grading was performed and correlation analysis was conducted for T
, T
and DWI results with the grading results and age. Pfirrmann grading indicated 69 cases of grade I, 240 cases of grade II, 101 cases of grade III, 43 cases of grade IV and 12 cases of grade V. MRI showed that the T
values of the nucleus pulposi at L4/5 and L5/S1 were significantly reduced (P<0.05) and no significant differences were observed in the T
values compared with the values of the nucleus pulposus at L1/2, L2/3 and L3/4. The apparent diffusion coefficient (ADC) values of L1/2 were significantly decreased from L2/3 and L3/4 (P<0.05). Correlation analysis revealed that the T
, T, and ADC values were positively correlated with each other. Moreover, the T
values were significantly decreased with the increase of Pfirrmann grades (P<0.05), with the exception of grades IV and V. However, T
and ADC values were not significantly different between grades I and II or IV and V. In addition, the T
, T
and ADC values were significantly decreased with the increase of age in patients with IDD (P<0.05). T
and T
mapping and DWI are promising techniques for the
diagnosis of IDD, which may be useful in determining the appropriate prevention and treatment options for the disease. The present study investigated the application of the T1ρ and T2 relaxation mapping magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) in the evaluation of intervertebral disc degeneration (IDD). A total of 93 asymptomatic subjects were imaged with T1ρ and T2 mapping, as well as DWI. Pfirrmann grading was performed and correlation analysis was conducted for T1ρ, T2 and DWI results with the grading results and age. Pfirrmann grading indicated 69 cases of grade I, 240 cases of grade II, 101 cases of grade III, 43 cases of grade IV and 12 cases of grade V. MRI showed that the T1ρ values of the nucleus pulposi at L4/5 and L5/S1 were significantly reduced (P<0.05) and no significant differences were observed in the T2 values compared with the values of the nucleus pulposus at L1/2, L2/3 and L3/4. The apparent diffusion coefficient (ADC) values of L1/2 were significantly decreased from L2/3 and L3/4 (P<0.05). Correlation analysis revealed that the T1ρ, T, and ADC values were positively correlated with each other. Moreover, the T1ρvalues were significantly decreased with the increase of Pfirrmann grades (P<0.05), with the exception of grades IV and V. However, T2 and ADC values were not significantly different between grades I and II or IV and V. In addition, the T1ρ, T2 and ADC values were significantly decreased with the increase of age in patients with IDD (P<0.05). T1ρ and T2 mapping and DWI are promising techniques for the in vivo diagnosis of IDD, which may be useful in determining the appropriate prevention and treatment options for the disease. The present study investigated the application of the T 1ρ and T 2 relaxation mapping magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) in the evaluation of intervertebral disc degeneration (IDD). A total of 93 asymptomatic subjects were imaged with T 1ρ and T 2 mapping, as well as DWI. Pfirrmann grading was performed and correlation analysis was conducted for T 1ρ , T 2 and DWI results with the grading results and age. Pfirrmann grading indicated 69 cases of grade I, 240 cases of grade II, 101 cases of grade III, 43 cases of grade IV and 12 cases of grade V. MRI showed that the T 1ρ values of the nucleus pulposi at L4/5 and L5/S1 were significantly reduced (P<0.05) and no significant differences were observed in the T 2 values compared with the values of the nucleus pulposus at L1/2, L2/3 and L3/4. The apparent diffusion coefficient (ADC) values of L1/2 were significantly decreased from L2/3 and L3/4 (P<0.05). Correlation analysis revealed that the T 1ρ , T, and ADC values were positively correlated with each other. Moreover, the T 1ρ values were significantly decreased with the increase of Pfirrmann grades (P<0.05), with the exception of grades IV and V. However, T 2 and ADC values were not significantly different between grades I and II or IV and V. In addition, the T 1ρ , T 2 and ADC values were significantly decreased with the increase of age in patients with IDD (P<0.05). T 1ρ and T 2 mapping and DWI are promising techniques for the in vivo diagnosis of IDD, which may be useful in determining the appropriate prevention and treatment options for the disease. The present study investigated the application of the [T.sub.1[rho]] and [T.sub.2] relaxation mapping magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) in the evaluation of intervertebral disc degeneration (IDD). A total of 93 asymptomatic subjects were imaged with [T.sub.1[rho]] and [T.sub.2] mapping, as well as DWI. Pfirrmann grading was performed and correlation analysis was conducted for [T.sub.1[rho]], [T.sub.2] and DWI results with the grading results and age. Pfirrmann grading indicated 69 cases of grade I, 240 cases of grade II, 101 cases of grade III, 43 cases of grade IV and 12 cases of grade V. MRI showed that the [T.sub.1[rho]] values of the nucleus pulposi at L4/5 and L5/S1 were significantly reduced (P < 0.05) and no significant differences were observed in the [T.sub.2] values compared with the values of the nucleus pulposus at L1/2, L2/3 and L3/4. The apparent diffusion coefficient (ADC) values of L1/2 were significantly decreased from L2/3 and L3/4 (P < 0.05). Correlation analysis revealed that the [T.sub.1[rho]], T, and ADC values were positively correlated with each other. Moreover, the [T.sub.1[rho]]values were significantly decreased with the increase of Pfirrmann grades (P < 0.05), with the exception of grades IV and V. However, [T.sub.2] and ADC values were not significantly different between grades I and II or IV and V. In addition, the [T.sub.1[rho]], [T.sub.2] and ADC values were significantly decreased with the increase of age in patients with IDD (P < 0.05). [T.sub.1[rho]] and [T.sub.2] mapping and DWI are promising techniques for the in vivo diagnosis of IDD, which may be useful in determining the appropriate prevention and treatment options for the disease. Key words: intervertebral disc degeneration, magnetic resonance imaging, [T.sub.1[rho]], [T.sub.2], diffusion-weighted imaging The present study investigated the application of the T1ρ and T2 relaxation mapping magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) in the evaluation of intervertebral disc degeneration (IDD). A total of 93 asymptomatic subjects were imaged with T1ρ and T2 mapping, as well as DWI. Pfirrmann grading was performed and correlation analysis was conducted for T1ρ, T2 and DWI results with the grading results and age. Pfirrmann grading indicated 69 cases of grade I, 240 cases of grade II, 101 cases of grade III, 43 cases of grade IV and 12 cases of grade V. MRI showed that the T1ρ values of the nucleus pulposi at L4/5 and L5/S1 were significantly reduced (P<0.05) and no significant differences were observed in the T2 values compared with the values of the nucleus pulposus at L1/2, L2/3 and L3/4. The apparent diffusion coefficient (ADC) values of L1/2 were significantly decreased from L2/3 and L3/4 (P<0.05). Correlation analysis revealed that the T1ρ, T, and ADC values were positively correlated with each other. Moreover, the T1ρvalues were significantly decreased with the increase of Pfirrmann grades (P<0.05), with the exception of grades IV and V. However, T2 and ADC values were not significantly different between grades I and II or IV and V. In addition, the T1ρ, T2 and ADC values were significantly decreased with the increase of age in patients with IDD (P<0.05). T1ρ and T2 mapping and DWI are promising techniques for the in vivo diagnosis of IDD, which may be useful in determining the appropriate prevention and treatment options for the disease.The present study investigated the application of the T1ρ and T2 relaxation mapping magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) in the evaluation of intervertebral disc degeneration (IDD). A total of 93 asymptomatic subjects were imaged with T1ρ and T2 mapping, as well as DWI. Pfirrmann grading was performed and correlation analysis was conducted for T1ρ, T2 and DWI results with the grading results and age. Pfirrmann grading indicated 69 cases of grade I, 240 cases of grade II, 101 cases of grade III, 43 cases of grade IV and 12 cases of grade V. MRI showed that the T1ρ values of the nucleus pulposi at L4/5 and L5/S1 were significantly reduced (P<0.05) and no significant differences were observed in the T2 values compared with the values of the nucleus pulposus at L1/2, L2/3 and L3/4. The apparent diffusion coefficient (ADC) values of L1/2 were significantly decreased from L2/3 and L3/4 (P<0.05). Correlation analysis revealed that the T1ρ, T, and ADC values were positively correlated with each other. Moreover, the T1ρvalues were significantly decreased with the increase of Pfirrmann grades (P<0.05), with the exception of grades IV and V. However, T2 and ADC values were not significantly different between grades I and II or IV and V. In addition, the T1ρ, T2 and ADC values were significantly decreased with the increase of age in patients with IDD (P<0.05). T1ρ and T2 mapping and DWI are promising techniques for the in vivo diagnosis of IDD, which may be useful in determining the appropriate prevention and treatment options for the disease. The present study investigated the application of the [T.sub.1[rho]] and [T.sub.2] relaxation mapping magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) in the evaluation of intervertebral disc degeneration (IDD). A total of 93 asymptomatic subjects were imaged with [T.sub.1[rho]] and [T.sub.2] mapping, as well as DWI. Pfirrmann grading was performed and correlation analysis was conducted for [T.sub.1[rho]], [T.sub.2] and DWI results with the grading results and age. Pfirrmann grading indicated 69 cases of grade I, 240 cases of grade II, 101 cases of grade III, 43 cases of grade IV and 12 cases of grade V. MRI showed that the [T.sub.1[rho]] values of the nucleus pulposi at L4/5 and L5/S1 were significantly reduced (P < 0.05) and no significant differences were observed in the [T.sub.2] values compared with the values of the nucleus pulposus at L1/2, L2/3 and L3/4. The apparent diffusion coefficient (ADC) values of L1/2 were significantly decreased from L2/3 and L3/4 (P < 0.05). Correlation analysis revealed that the [T.sub.1[rho]], T, and ADC values were positively correlated with each other. Moreover, the [T.sub.1[rho]]values were significantly decreased with the increase of Pfirrmann grades (P < 0.05), with the exception of grades IV and V. However, [T.sub.2] and ADC values were not significantly different between grades I and II or IV and V. In addition, the [T.sub.1[rho]], [T.sub.2] and ADC values were significantly decreased with the increase of age in patients with IDD (P < 0.05). [T.sub.1[rho]] and [T.sub.2] mapping and DWI are promising techniques for the in vivo diagnosis of IDD, which may be useful in determining the appropriate prevention and treatment options for the disease. |
| Audience | Academic |
| Author | Han, Hongbin Liang, Wen Wang, Wei Hou, Jin Quan, Xianyue Jiang, Xinqing Lv, Deyong |
| AuthorAffiliation | 3 Department of Radiology and Beijing MRI Technology Research Laboratory, Peking University Third Hospital, Beijing 100191, P.R. China 2 Department of Radiology, Guangzhou First People's Hospital, Guangzhou, Guangdong 510180, P.R. China 1 Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510280, P.R. China 5 Department of Radiology, Dongying People's Hospital of Shandong, Dongying, Shandong 257091, P.R. China 4 Department of Radiology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510260, P.R. China |
| AuthorAffiliation_xml | – name: 2 Department of Radiology, Guangzhou First People's Hospital, Guangzhou, Guangdong 510180, P.R. China – name: 5 Department of Radiology, Dongying People's Hospital of Shandong, Dongying, Shandong 257091, P.R. China – name: 1 Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510280, P.R. China – name: 4 Department of Radiology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510260, P.R. China – name: 3 Department of Radiology and Beijing MRI Technology Research Laboratory, Peking University Third Hospital, Beijing 100191, P.R. China |
| Author_xml | – sequence: 1 givenname: Wei surname: Wang fullname: Wang, Wei organization: 1Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510280, P.R. China – sequence: 2 givenname: Jin surname: Hou fullname: Hou, Jin organization: 4Department of Radiology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510260, P.R. China – sequence: 3 givenname: Deyong surname: Lv fullname: Lv, Deyong organization: 5Department of Radiology, Dongying People's Hospital of Shandong, Dongying, Shandong 257091, P.R. China – sequence: 4 givenname: Wen surname: Liang fullname: Liang, Wen organization: 1Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510280, P.R. China – sequence: 5 givenname: Xinqing surname: Jiang fullname: Jiang, Xinqing organization: 2Department of Radiology, Guangzhou First People's Hospital, Guangzhou, Guangdong 510180, P.R. China – sequence: 6 givenname: Hongbin surname: Han fullname: Han, Hongbin organization: 3Department of Radiology and Beijing MRI Technology Research Laboratory, Peking University Third Hospital, Beijing 100191, P.R. China – sequence: 7 givenname: Xianyue surname: Quan fullname: Quan, Xianyue organization: 1Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510280, P.R. China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28962127$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1186_s43055_019_0042_7 crossref_primary_10_3390_ijms21113748 crossref_primary_10_1055_s_0043_1772823 crossref_primary_10_1371_journal_pone_0227894 crossref_primary_10_1177_1753425919895086 crossref_primary_10_7759_cureus_59966 crossref_primary_10_1016_j_ejrad_2022_110358 crossref_primary_10_1371_journal_pone_0314021 |
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| Copyright | Copyright: © Wang et al. COPYRIGHT 2017 Spandidos Publications Copyright Spandidos Publications UK Ltd. 2017 Copyright: © Wang et al. 2017 |
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| Keywords | intervertebral disc degeneration magnetic resonance imaging T1ρ diffusion-weighted imaging T2 |
| Language | English |
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| Snippet | The present study investigated the application of the T1ρ and T2 relaxation mapping magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) in... The present study investigated the application of the T and T relaxation mapping magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) in the... The present study investigated the application of the [T.sub.1[rho]] and [T.sub.2] relaxation mapping magnetic resonance imaging (MRI) and diffusion-weighted... The present study investigated the application of the T 1ρ and T 2 relaxation mapping magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) in... |
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| SubjectTerms | Age Diagnosis diffusion-weighted imaging intervertebral disc degeneration Magnetic resonance imaging Methods Neurodegenerative diseases NMR Nuclear magnetic resonance Statistical analysis Studies T1ρ T2 |
| Title | Multimodal quantitative magnetic resonance imaging for lumbar intervertebral disc degeneration |
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