Central and peripheral markers of neurodegeneration and monocyte activation in HIV-associated neurocognitive disorders

• Published in: Journal of neurovirology Vol. 21; no. 4; pp. 439 - 448
• Main Authors: McGuire, Jennifer L, Gill, Alexander J, Douglas, Steven D, Kolson, Dennis L
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2015
• Subjects: Adult; AIDS Dementia Complex - cerebrospinal fluid; AIDS Dementia Complex - immunology; AIDS Dementia Complex - pathology; Biomarkers - analysis; Biomedical and Life Sciences; Biomedicine; Cross-Sectional Studies; Female; Humans; Immunology; Infectious Diseases; Macrophage Activation; Male; Middle Aged; Monocytes - immunology; Nerve Degeneration - virology; Neurofilament Proteins - cerebrospinal fluid; Neurology; Neuropsychological Tests; Neurosciences; Retrospective Studies; Virology; Neurofilament; sCD14; HIV; pNFH; NFL; Neurodegeneration; sCD163; Neuroinflammation; Monocyte activation; HAND; Macrophage

HIV-associated neurocognitive disorders (HAND) affect up to 50 % of HIV-infected adults, independently predict HIV morbidity/mortality, and are associated with neuronal damage and monocyte activation. Cerebrospinal fluid (CSF) neurofilament subunits (NFL, pNFH) are sensitive surrogate markers of neu...