Intracellular Activation of Protein Kinase C and Regulation of the Surface Transferrin Receptor by Diacylglycerol is a Spontaneously Reversible Process That is Associated with Rapid Formation of Phosphatidic Acid

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 83; no. 5; pp. 1281 - 1284
• Main Authors: May, W. Stratford, Lapetina, Eduardo G., Cuatrecasas, Pedro
• Format: Journal Article
• Language: English
• Published: Washington, DC National Academy of Sciences of the United States of America 01.03.1986; National Acad Sciences
• Subjects: Biological and medical sciences; Calcimycin - pharmacology; Cell receptors; Cell structures and functions; Chromatography; Diglycerides; Diglycerides - pharmacology; Down regulation; Drug Synergism; Enzyme Activation - drug effects; Fundamental and applied biological sciences. Psychology; Glycerides - pharmacology; Humans; Molecular and cellular biology; Phorbol esters; Phosphatidic acids; Phosphatidic Acids - physiology; Phospholipids; Phosphorylation; Protein Kinase C - metabolism; Protein metabolism; Receptors; Receptors, Cell Surface - metabolism; Receptors, Transferrin; Transferrin receptors; Human origin; Cell culture; Regulation(control); Transferrin; Diglyceride; Protein kinase; Internalization; Activation; Intracellular; Phosphatidic acid; Biological receptor

The effect of the synthetic diacylglycerol, sn-1,2-dioctanoylglycerol (diC8), on the expression of the surface transferrin receptor reveals that exogenous diC8 can act as an intracellular activator of protein kinase C and stimulate both down-regulation and increased receptor phosphorylation in a man...