Tumour angiogenesis: The gap between theory and experiments

• Published in: Journal of theoretical biology Vol. 274; no. 1; pp. 97 - 102
• Main Authors: Schofield, J.W., Gaffney, E.A., Gatenby, R.A., Maini, P.K.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 07.04.2011; Elsevier
• Subjects: angiogenesis; Animals; Avascular; blood vessels; Cell Proliferation; Cornea; Cornea - blood supply; Cornea - pathology; Humans; image analysis; Kinetics; Life Sciences; mathematical models; Mice; Modelling; Models, Biological; neoplasms; Neoplasms - blood supply; Neoplasms - pathology; Neovascularization, Pathologic - pathology; Spheroid; Cornea; Avascular; Spheroid; Modelling

A common experimental technique for viewing in vivo angiogenesis utilises tumours implanted into a test animal cornea. The cornea is avascular but the tumour promotes vascularisation from the limbus and the new blood vessels can be readily observed through the transparent cornea. Many of the early m...