Neuroprotection by dihydrotestosterone in LPS-induced neuroinflammation

• Published in: Neurobiology of disease Vol. 140; p. 104814
• Main Authors: Yang, Lei, Zhou, Renyuan, Tong, Yu, Chen, Pengfei, Shen, Yu, Miao, Shuai, Liu, Xiaoqiang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2020; Elsevier
• Subjects: Cognitive impairment; Dihydrotestosterone; Lipopolysaccharide; Neuroinflammation; Sickness behavior; NO; COX-2; PT; LPS; Aβ; DHT; NF-κB; Dihydrotestosterone; RT-PCR; Lipopolysaccharide; CCK-8; iNOS; OFT; Cognitive impairment; PGE2; MWM; AD; IL; MS; Neuroinflammation; MAPK; Sickness behavior; PD; TNF-α; TLR4; ELISA

Microglia-induced neuroinflammation plays a vital role in the etiology and progression of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and multiple sclerosis. The neuroprotective role of androgens, including testosterone and its metabolite dihydrotestoster...