A Clinical Overview of Centrosome Amplification in Human Cancers
The turn of the 21st century had witnessed a surge of interest in the centrosome and its causal relation to human cancer development - a postulate that has existed for almost a century. Centrosome amplification (CA) is frequently detected in a growing list of human cancers, both solid and haematolog...
Saved in:
| Published in | International journal of biological sciences Vol. 7; no. 8; pp. 1122 - 1144 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Australia
Ivyspring International Publisher
01.01.2011
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The turn of the 21st century had witnessed a surge of interest in the centrosome and its causal relation to human cancer development - a postulate that has existed for almost a century. Centrosome amplification (CA) is frequently detected in a growing list of human cancers, both solid and haematological, and is a candidate "hallmark" of cancer cells. Several lines of evidence support the progressive involvement of CA in the transition from early to advanced stages of carcinogenesis, being also found in pre-neoplastic lesions and even in histopathologically-normal tissue. CA constitutes the major mechanism leading to chromosomal instability and aneuploidy, via the formation of multipolar spindles and chromosomal missegregation. Clinically, CA may translate to a greater risk for initiation of malignant transformation, tumour progression, chemoresistance and ultimately, poor patient prognosis. As mechanisms underlying CA are progressively being unravelled, the centrosome has emerged as a novel candidate target for cancer treatment. This Review summarizes mainly the clinical studies performed to date focusing on the mechanisms underlying CA in human neoplasia, and highlights the potential utility of centrosomes in the diagnosis, prognosis and treatment of human cancers. |
|---|---|
| AbstractList | The turn of the 21st century had witnessed a surge of interest in the centrosome and its causal relation to human cancer development - a postulate that has existed for almost a century. Centrosome amplification (CA) is frequently detected in a growing list of human cancers, both solid and haematological, and is a candidate "hallmark" of cancer cells. Several lines of evidence support the progressive involvement of CA in the transition from early to advanced stages of carcinogenesis, being also found in pre-neoplastic lesions and even in histopathologically-normal tissue. CA constitutes the major mechanism leading to chromosomal instability and aneuploidy, via the formation of multipolar spindles and chromosomal missegregation. Clinically, CA may translate to a greater risk for initiation of malignant transformation, tumour progression, chemoresistance and ultimately, poor patient prognosis. As mechanisms underlying CA are progressively being unravelled, the centrosome has emerged as a novel candidate target for cancer treatment. This Review summarizes mainly the clinical studies performed to date focusing on the mechanisms underlying CA in human neoplasia, and highlights the potential utility of centrosomes in the diagnosis, prognosis and treatment of human cancers. The turn of the 21st century had witnessed a surge of interest in the centrosome and its causal relation to human cancer development - a postulate that has existed for almost a century. Centrosome amplification (CA) is frequently detected in a growing list of human cancers, both solid and haematological, and is a candidate "hallmark" of cancer cells. Several lines of evidence support the progressive involvement of CA in the transition from early to advanced stages of carcinogenesis, being also found in pre-neoplastic lesions and even in histopathologically-normal tissue. CA constitutes the major mechanism leading to chromosomal instability and aneuploidy, via the formation of multipolar spindles and chromosomal missegregation. Clinically, CA may translate to a greater risk for initiation of malignant transformation, tumour progression, chemoresistance and ultimately, poor patient prognosis. As mechanisms underlying CA are progressively being unravelled, the centrosome has emerged as a novel candidate target for cancer treatment. This Review summarizes mainly the clinical studies performed to date focusing on the mechanisms underlying CA in human neoplasia, and highlights the potential utility of centrosomes in the diagnosis, prognosis and treatment of human cancers.The turn of the 21st century had witnessed a surge of interest in the centrosome and its causal relation to human cancer development - a postulate that has existed for almost a century. Centrosome amplification (CA) is frequently detected in a growing list of human cancers, both solid and haematological, and is a candidate "hallmark" of cancer cells. Several lines of evidence support the progressive involvement of CA in the transition from early to advanced stages of carcinogenesis, being also found in pre-neoplastic lesions and even in histopathologically-normal tissue. CA constitutes the major mechanism leading to chromosomal instability and aneuploidy, via the formation of multipolar spindles and chromosomal missegregation. Clinically, CA may translate to a greater risk for initiation of malignant transformation, tumour progression, chemoresistance and ultimately, poor patient prognosis. As mechanisms underlying CA are progressively being unravelled, the centrosome has emerged as a novel candidate target for cancer treatment. This Review summarizes mainly the clinical studies performed to date focusing on the mechanisms underlying CA in human neoplasia, and highlights the potential utility of centrosomes in the diagnosis, prognosis and treatment of human cancers. |
| Author | Chan, Jason Yongsheng |
| AuthorAffiliation | Medical Resident, Ministry of Health Holdings, Singapore |
| AuthorAffiliation_xml | – name: Medical Resident, Ministry of Health Holdings, Singapore |
| Author_xml | – sequence: 1 givenname: Jason Yongsheng surname: Chan fullname: Chan, Jason Yongsheng |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22043171$$D View this record in MEDLINE/PubMed |
| BookMark | eNptkc1vGyEUxFGVqkncnnqv9tZDZffxtcClqrVqmkiRcskdsSykWLvgwtpR__viOImSqicQzPuN3sw5OokpOoQ-YlgJzOFr2PRlJVYYE_IGnWHG1JIQKU9e3E_ReSkbANpyCe_QKSHAKBb4DH1fN90YYrBmbG72Lu-Du2-SbzoX55xKmlyznrZj8FUxhxSbEJvL3WRi05loXS7v0VtvxuI-PJ4LdHvx47a7XF7f_Lzq1tdLyzGZl7iVvRMCy96Ckj21mLWt4hKDJV5Ywj2ovufcgRqUF0YyPxBCpTFECQJ0ga6O2CGZjd7mMJn8RycT9MNDynfa5DnY0WkrOYCnILkZmMFKqgEck3ZwQKkZ-sr6dmRtd_3kBntY1YyvoK9_Yvil79Je0xobq8kt0OdHQE6_d67MegrFunE00aVd0Qpwy7CEtio_vbR69ngqoArwUWBr2iU7r22YH5KuzmHUGPShZH0oWQt9KLnOfPln5gn7P_VfAcin6w |
| CitedBy_id | crossref_primary_10_1016_j_canlet_2012_02_006 crossref_primary_10_1146_annurev_biochem_013118_111153 crossref_primary_10_3390_ijms21082772 crossref_primary_10_1007_s10577_015_9507_3 crossref_primary_10_1073_pnas_1519388112 crossref_primary_10_1007_s10577_023_09741_9 crossref_primary_10_1016_j_devcel_2018_10_026 crossref_primary_10_1371_journal_pcbi_1006832 crossref_primary_10_15252_embj_2023113510 crossref_primary_10_1016_j_molmed_2019_04_004 crossref_primary_10_18632_oncotarget_27623 crossref_primary_10_1186_s40364_016_0059_2 crossref_primary_10_1155_2012_541906 crossref_primary_10_1007_s10147_017_1182_2 crossref_primary_10_15252_embr_201643030 crossref_primary_10_1038_nature13277 crossref_primary_10_1080_00365521_2024_2411405 crossref_primary_10_1002_cjp2_272 crossref_primary_10_1016_j_copbio_2016_03_011 crossref_primary_10_1016_j_jid_2020_11_012 crossref_primary_10_1016_j_ejogrb_2014_11_001 crossref_primary_10_1158_1078_0432_CCR_16_1562 crossref_primary_10_3109_10428194_2013_845883 crossref_primary_10_1016_j_drup_2015_11_002 crossref_primary_10_1002_jcp_24272 crossref_primary_10_1007_s00418_018_1698_1 crossref_primary_10_15252_embr_202050893 crossref_primary_10_3892_ijo_2019_4762 crossref_primary_10_1111_jnc_15660 crossref_primary_10_1016_j_isci_2022_105745 crossref_primary_10_3389_fgene_2018_00738 crossref_primary_10_1158_1535_7163_MCT_18_0864 crossref_primary_10_3390_molecules25081778 crossref_primary_10_1007_s12185_018_2406_6 crossref_primary_10_1242_jcs_240838 crossref_primary_10_1091_mbc_E22_12_0572 crossref_primary_10_1002_1878_0261_12687 crossref_primary_10_1080_15384047_2023_2279241 crossref_primary_10_1371_journal_pone_0133769 crossref_primary_10_1146_annurev_pharmtox_010818_021649 crossref_primary_10_1016_j_bbcan_2016_06_002 crossref_primary_10_1016_j_ijbiomac_2024_132347 crossref_primary_10_1111_gtc_12741 crossref_primary_10_1158_1078_0432_CCR_19_1272 crossref_primary_10_14348_molcells_2021_0220 crossref_primary_10_3390_ijms22189680 crossref_primary_10_1016_j_bcp_2017_11_003 crossref_primary_10_18632_aging_204711 crossref_primary_10_1016_j_acthis_2014_11_009 crossref_primary_10_18632_oncotarget_13249 crossref_primary_10_1016_j_freeradbiomed_2024_11_001 crossref_primary_10_1016_j_compbiolchem_2024_108317 crossref_primary_10_18632_oncotarget_18139 crossref_primary_10_3390_ijms20092112 crossref_primary_10_1042_BST20200833 crossref_primary_10_1016_j_isci_2019_07_018 crossref_primary_10_1111_cas_13717 crossref_primary_10_4161_cc_29061 crossref_primary_10_1038_ncb2958 crossref_primary_10_4161_cc_24602 crossref_primary_10_1111_ahg_12529 crossref_primary_10_1038_s41598_020_68629_4 crossref_primary_10_1186_s12964_017_0204_z crossref_primary_10_1007_s00432_019_02994_0 crossref_primary_10_1517_14728222_2015_1018823 crossref_primary_10_1007_s12079_021_00661_z crossref_primary_10_15252_embj_201798576 crossref_primary_10_1016_j_pbj_2017_07_019 crossref_primary_10_1016_j_semcdb_2020_04_019 crossref_primary_10_1083_jcb_201711191 crossref_primary_10_1016_j_stem_2019_11_014 crossref_primary_10_1016_j_ydbio_2024_09_006 crossref_primary_10_1091_mbc_E18_10_0674 crossref_primary_10_1038_ncomms2752 crossref_primary_10_1038_s42003_021_02887_4 crossref_primary_10_1038_srep43984 crossref_primary_10_1016_j_drudis_2013_10_022 crossref_primary_10_1073_pnas_1518376112 crossref_primary_10_1038_s44319_024_00260_0 crossref_primary_10_7554_eLife_73944 crossref_primary_10_3390_cancers14020442 crossref_primary_10_3390_jpm11121361 crossref_primary_10_1016_j_mrgentox_2019_02_004 crossref_primary_10_1007_s10555_012_9413_5 crossref_primary_10_1038_s41388_019_0995_z crossref_primary_10_1002_slct_202104218 crossref_primary_10_1186_s40880_016_0121_3 crossref_primary_10_1007_s41745_020_00213_1 crossref_primary_10_1242_jcs_261150 crossref_primary_10_1007_s00018_021_03928_1 crossref_primary_10_21769_BioProtoc_3396 crossref_primary_10_1038_cddis_2014_505 crossref_primary_10_1016_j_isci_2022_104217 crossref_primary_10_1016_j_celrep_2015_08_045 crossref_primary_10_18632_oncotarget_4958 crossref_primary_10_1042_BST20190034 crossref_primary_10_1016_j_cub_2021_01_028 crossref_primary_10_1080_19420889_2018_1526605 crossref_primary_10_18632_aging_204141 crossref_primary_10_1016_j_sjbs_2022_103436 crossref_primary_10_1158_1541_7786_MCR_20_0798 crossref_primary_10_1007_s00018_022_04258_6 crossref_primary_10_15252_embj_201899422 crossref_primary_10_7554_eLife_54565 crossref_primary_10_1083_jcb_201502088 crossref_primary_10_1158_1535_7163_MCT_17_1108 crossref_primary_10_3727_096504018X15213115046567 crossref_primary_10_1371_journal_pone_0061664 crossref_primary_10_1111_cas_14859 crossref_primary_10_1242_jcs_213579 crossref_primary_10_1016_j_genrep_2021_101481 crossref_primary_10_1091_mbc_E18_10_0651 crossref_primary_10_3389_fonc_2021_587554 crossref_primary_10_1098_rsob_200060 crossref_primary_10_1016_j_sbi_2020_09_011 crossref_primary_10_1038_cdd_2016_122 crossref_primary_10_1038_s41467_020_20208_x crossref_primary_10_1074_jbc_M113_499319 crossref_primary_10_1038_s41598_023_29712_8 crossref_primary_10_1007_s00277_013_1772_7 crossref_primary_10_1007_s10555_020_09937_z crossref_primary_10_1101_gad_314351_118 crossref_primary_10_1007_s12032_021_01494_x crossref_primary_10_1083_jcb_202107134 crossref_primary_10_18632_oncotarget_7572 crossref_primary_10_1038_modpathol_2012_120 crossref_primary_10_1016_j_toxlet_2024_01_001 crossref_primary_10_1016_j_canlet_2018_12_004 crossref_primary_10_1038_s41598_017_00363_w crossref_primary_10_3389_fonc_2024_1370565 crossref_primary_10_1038_s41585_023_00845_9 crossref_primary_10_1038_s41598_020_65975_1 crossref_primary_10_1091_mbc_E19_04_0195 crossref_primary_10_1016_j_ijscr_2025_110890 crossref_primary_10_1016_j_mam_2015_05_001 crossref_primary_10_1038_oncsis_2015_37 crossref_primary_10_3390_jcm8020225 crossref_primary_10_1016_j_bbrc_2022_10_092 crossref_primary_10_3390_cells8070701 crossref_primary_10_1083_jcb_202311140 crossref_primary_10_1016_j_ejca_2013_07_015 crossref_primary_10_1038_s41420_024_02190_1 crossref_primary_10_1186_s13008_022_00077_0 crossref_primary_10_1186_s12885_016_2083_x crossref_primary_10_1038_s41467_018_03283_z crossref_primary_10_1080_15384101_2016_1138185 crossref_primary_10_18632_oncotarget_8799 crossref_primary_10_1146_annurev_cellbio_120219_051400 crossref_primary_10_1158_1541_7786_MCR_19_0509 crossref_primary_10_1016_j_bpj_2021_05_030 crossref_primary_10_1038_nrm4062 crossref_primary_10_1115_1_4028855 crossref_primary_10_1073_pnas_2303487120 crossref_primary_10_1186_s13039_019_0429_1 crossref_primary_10_1158_0008_5472_CAN_13_2049 crossref_primary_10_1038_s41419_023_05618_1 crossref_primary_10_1158_1535_7163_MCT_20_0741 crossref_primary_10_1186_2041_9414_4_5 crossref_primary_10_15252_embr_202153805 crossref_primary_10_1083_jcb_201704102 crossref_primary_10_1080_15384101_2021_1950386 crossref_primary_10_3892_ol_2017_5633 crossref_primary_10_1038_s44319_024_00361_w crossref_primary_10_3389_fphys_2022_948965 crossref_primary_10_3390_cancers13184531 crossref_primary_10_1016_j_redox_2025_103582 crossref_primary_10_1038_bjc_2015_264 crossref_primary_10_3390_cancers12020517 crossref_primary_10_1093_toxsci_kfx229 crossref_primary_10_1002_jcp_27813 crossref_primary_10_1093_nar_gkt1126 crossref_primary_10_1371_journal_pone_0090332 crossref_primary_10_1083_jcb_201910019 crossref_primary_10_1158_1541_7786_MCR_20_0639 crossref_primary_10_3892_or_2015_4014 crossref_primary_10_1038_s41392_024_01767_7 crossref_primary_10_1158_1541_7786_MCR_17_0197 crossref_primary_10_18632_oncotarget_26714 crossref_primary_10_3390_genes12040558 crossref_primary_10_4161_org_25144 crossref_primary_10_1517_14728222_2013_731396 crossref_primary_10_1158_0008_5472_CAN_16_1144 crossref_primary_10_1007_s00428_020_02895_5 crossref_primary_10_1016_j_bbagen_2022_130099 crossref_primary_10_1098_rsob_220229 crossref_primary_10_1371_journal_pcbi_1008765 crossref_primary_10_1016_j_mrgentox_2019_03_005 crossref_primary_10_3390_ijms24043733 crossref_primary_10_1007_s10555_024_10224_4 crossref_primary_10_1016_j_bmc_2017_02_030 crossref_primary_10_1080_15384101_2015_1068478 crossref_primary_10_1038_ncomms9450 crossref_primary_10_1093_toxsci_kfv146 crossref_primary_10_1101_sqb_2017_82_034421 crossref_primary_10_1371_journal_pone_0191734 crossref_primary_10_1016_j_chembiol_2013_09_012 crossref_primary_10_26508_lsa_202201499 crossref_primary_10_1186_1757_2215_6_55 crossref_primary_10_3390_cells11030432 crossref_primary_10_15252_embj_2020105106 crossref_primary_10_1016_j_devcel_2016_12_022 crossref_primary_10_1038_onc_2016_74 crossref_primary_10_1091_mbc_E22_10_0485 crossref_primary_10_1371_journal_pgen_1011343 crossref_primary_10_1016_j_canep_2013_04_018 crossref_primary_10_1038_cddis_2014_164 crossref_primary_10_1186_s12976_016_0042_5 crossref_primary_10_1016_j_ddmec_2013_03_002 crossref_primary_10_1098_rsob_170202 crossref_primary_10_1002_gcc_22426 crossref_primary_10_1016_j_tice_2019_09_003 crossref_primary_10_1074_jbc_M113_532333 crossref_primary_10_1016_j_prp_2023_154742 crossref_primary_10_1007_s10577_015_9505_5 crossref_primary_10_1007_s10549_017_4147_2 crossref_primary_10_4236_abb_2016_73015 crossref_primary_10_1016_j_bbadis_2024_167138 crossref_primary_10_1038_s41467_018_04122_x crossref_primary_10_1371_journal_pone_0129648 crossref_primary_10_1242_jcs_238931 crossref_primary_10_1111_cas_13595 crossref_primary_10_1038_srep26580 crossref_primary_10_1111_cmi_13397 crossref_primary_10_1093_carcin_bgw014 crossref_primary_10_1038_s41467_023_41840_3 crossref_primary_10_1371_journal_pone_0296779 crossref_primary_10_3109_10428194_2013_764416 crossref_primary_10_3390_molecules23051166 crossref_primary_10_3892_or_2015_3751 crossref_primary_10_1016_j_devcel_2019_04_002 crossref_primary_10_1016_j_molmed_2020_01_011 crossref_primary_10_1007_s00277_020_04007_4 crossref_primary_10_1038_nrc3995 crossref_primary_10_1038_s41467_019_10241_w crossref_primary_10_18632_oncotarget_27810 crossref_primary_10_1038_s41467_024_46306_8 crossref_primary_10_1098_rstb_2013_0467 crossref_primary_10_5483_BMBRep_2023_0025 crossref_primary_10_3748_wjg_v22_i41_9069 crossref_primary_10_1038_nrm_2017_127 crossref_primary_10_1038_s41388_022_02317_7 crossref_primary_10_3390_cells11223564 crossref_primary_10_1016_j_cub_2016_08_020 crossref_primary_10_3390_ijms221910883 crossref_primary_10_1111_jcmm_18135 crossref_primary_10_1186_1757_2215_7_53 crossref_primary_10_1530_ERC_17_0072 crossref_primary_10_1371_journal_pgen_1005039 crossref_primary_10_3390_cancers15010154 crossref_primary_10_4236_abb_2015_63017 crossref_primary_10_1158_1535_7163_MCT_19_0987 crossref_primary_10_3390_genes11080842 crossref_primary_10_4161_15384101_2014_964973 crossref_primary_10_18632_oncotarget_1198 crossref_primary_10_1158_0008_5472_CAN_16_3233 crossref_primary_10_1080_15384101_2018_1502567 crossref_primary_10_1111_cpr_12549 crossref_primary_10_18632_oncotarget_20765 crossref_primary_10_1007_s10549_012_2244_9 crossref_primary_10_3389_fcell_2023_1210983 crossref_primary_10_1126_sciadv_adk0564 crossref_primary_10_1038_s41467_018_03641_x crossref_primary_10_1186_s13578_021_00557_w crossref_primary_10_1016_j_bbcan_2019_05_008 crossref_primary_10_1002_pmic_201800197 crossref_primary_10_1038_ncomms15289 crossref_primary_10_1038_s41467_024_52129_4 crossref_primary_10_1186_s12964_024_01664_0 crossref_primary_10_1038_nature11941 |
| ContentType | Journal Article |
| Copyright | Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. 2011 |
| Copyright_xml | – notice: Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. 2011 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM DOA |
| DOI | 10.7150/ijbs.7.1122 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1449-2288 |
| EndPage | 1144 |
| ExternalDocumentID | oai_doaj_org_article_c8500f3085ad4a1989d0e48cde033adb PMC3204404 22043171 10_7150_ijbs_7_1122 |
| Genre | Journal Article Review |
| GroupedDBID | --- 29J 2WC 4.4 53G 5GY 5VS AAYXX ACGFO ACIWK ACPRK ADBBV ADRAZ AENEX AEUYN AFKRA AFRAH ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV BENPR C1A CCPQU CITATION DIK DU5 E3Z EBS EJD EMOBN F5P GROUPED_DOAJ GX1 HYE KQ8 M48 M~E O5R O5S OK1 OVT PGMZT PHGZM PHGZT PIMPY RNS RPM TR2 WOQ WOW XSB CGR CUY CVF ECM EIF NPM 7X8 5PM |
| ID | FETCH-LOGICAL-c512t-168be7718bc098b3c146695810c2f7c25f09bb55e09d9f7a84fd2238aa297203 |
| IEDL.DBID | M48 |
| ISSN | 1449-2288 |
| IngestDate | Wed Aug 27 01:14:42 EDT 2025 Thu Aug 21 14:27:02 EDT 2025 Fri Jul 11 04:42:15 EDT 2025 Thu Apr 03 07:06:01 EDT 2025 Thu Apr 24 22:56:47 EDT 2025 Tue Jul 01 04:07:33 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 8 |
| Keywords | aneuploidy aurora kinase Boveri hypothesis centrosome chromosomal instability p53 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c512t-168be7718bc098b3c146695810c2f7c25f09bb55e09d9f7a84fd2238aa297203 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Conflict of Interests: The authors have declared that no conflict of interest exists. |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.7150/ijbs.7.1122 |
| PMID | 22043171 |
| PQID | 901641806 |
| PQPubID | 23479 |
| PageCount | 23 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_c8500f3085ad4a1989d0e48cde033adb pubmedcentral_primary_oai_pubmedcentral_nih_gov_3204404 proquest_miscellaneous_901641806 pubmed_primary_22043171 crossref_citationtrail_10_7150_ijbs_7_1122 crossref_primary_10_7150_ijbs_7_1122 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2011-01-01 |
| PublicationDateYYYYMMDD | 2011-01-01 |
| PublicationDate_xml | – month: 01 year: 2011 text: 2011-01-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Australia |
| PublicationPlace_xml | – name: Australia – name: Sydney |
| PublicationTitle | International journal of biological sciences |
| PublicationTitleAlternate | Int J Biol Sci |
| PublicationYear | 2011 |
| Publisher | Ivyspring International Publisher |
| Publisher_xml | – name: Ivyspring International Publisher |
| SSID | ssj0036580 |
| Score | 2.4271271 |
| SecondaryResourceType | review_article |
| Snippet | The turn of the 21st century had witnessed a surge of interest in the centrosome and its causal relation to human cancer development - a postulate that has... |
| SourceID | doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 1122 |
| SubjectTerms | Aneuploidy Cell Transformation, Neoplastic - pathology Centrosome - pathology Chromosomal Instability - physiology Humans Models, Biological Neoplasms - etiology Review |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9wwEBYlEOilNOnLTVN02FPBjV62pFs3S8NSaHvZQm5CT7oltUt2N6H_vhrLu-yWQC8Fn2yBxXz2vDTzDUKTbOGSpVzUPrU5QNFU1CrkKAVmF7k2fwDJQe_w5y_t_Jv4dN1c7436gpqwQg9cBHfhVUNI4tkzsEFYqPAJJArlQySc2-BA-2abtw2mig7m2a4OrZBC6JoxpUpnnszez8Xyh1u9l9A6ww5s0UDZ_5Cf-Xe55J79uXqKnoyOI56WDZ-gR7E7RcdllOTvZ-jDFI8Unzf46x0ogHiP-4SH7G2_6n9GPIXi8TTm6PCyw0MCH88A99vVc7S4-riYzetxOkLts5Fe17RVLspsWpwnWjnus85rdaMo8SxJz5pEtHNNE4kOOkmrRArZF1DWMg1nry_QUdd38RXCMkrvuKRO-Siko44LaZkIsY1KBp8q9G4rJuNH5nAYYHFjcgQBMjUgUyMNyLRCk93iX4Uw4-FllyDv3RJguR5uZOzNiL35F_YVwlu0TP4r4KjDdrHfrIwG5jCqSFuhlwW83ZsYdANTSSskD2A92Mrhk275fSDe5gwGdIvX_2PvZ-hxSU_D9QYdrW838Tz7N2v3dviU_wBAfPiE priority: 102 providerName: Directory of Open Access Journals |
| Title | A Clinical Overview of Centrosome Amplification in Human Cancers |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/22043171 https://www.proquest.com/docview/901641806 https://pubmed.ncbi.nlm.nih.gov/PMC3204404 https://doaj.org/article/c8500f3085ad4a1989d0e48cde033adb |
| Volume | 7 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwdV1LT9wwELYQFVIvFS19BFrkA6dK2dqxEzsnSqsihAQnkLhZfrZbQdJuFgn-PTN5rLpoK-WUOE40Y_ubsWfmI-QIEC5ZLmTuUwUOSs1lrgN4Kchd5CoYAMlh7vDFZXV2Lc9vypstMpFxjgLsNrp2yCd1vbidPfx9PIYJD_brTIE982X-23UzhckwsBa_AEhSSGVwIVfHCQJglg3Jec9fwGLAmB7KFV9Dpr6A_yar83nw5D9odLpLXo1mJD0Z9P6abMXmDdkZiCUf98jXEzqlPFKM0cT9f9om2vfWdu1dpBZDydO4Y0fnDe3Z-qjHUbDo3pKr0x9X38_ykSsh9wDZy5xX2kUFQOM8q7UTHlbAqi41Z75IyhdlYrVzZRlZHeqkrJYpgGWgrS1qPIl9R7abtokfCFVReScUd9pHqRx3QipbyBCrqFXwKSOfJzEZP9YRRzqLWwP-BIrXoHiNMijejBytGv8ZymdsbvYN5b1qgjWv-xvt4qcZp5DxumQsCbARbZAWY70Ci1L7EJkQNriM0ElbBuYIHnzYJrb3namxjhjXrMrI-0F5qy9Nys-IWlPr2q-sP2nmv_oy3KJAum65_98-D8jLYQcar49ke7m4j5_AhFm6w971P-wH6ROgYvGH |
| linkProvider | Scholars Portal |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+clinical+overview+of+centrosome+amplification+in+human+cancers&rft.jtitle=International+journal+of+biological+sciences&rft.au=Chan%2C+Jason+Yongsheng&rft.date=2011-01-01&rft.eissn=1449-2288&rft.volume=7&rft.issue=8&rft.spage=1122&rft_id=info:doi/10.7150%2Fijbs.7.1122&rft_id=info%3Apmid%2F22043171&rft.externalDocID=22043171 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1449-2288&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1449-2288&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1449-2288&client=summon |