25-hydroxycholesterol: an integrator of antiviral ability and signaling

• Published in: Frontiers in immunology Vol. 14; p. 1268104
• Main Authors: Zhang, Jialu, Zhu, Yaohong, Wang, Xiaojia, Wang, Jiufeng
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 13.09.2023
• Subjects: antiviral effect; cholesterol metabolism; Immunology; interferon-independent pathways; oxysterol; signaling regulation

Cholesterol, as an important component in mammalian cells, is efficient for viral entry, replication, and assembly. Oxysterols especially hydroxylated cholesterols are recognized as novel regulators of the innate immune response. The antiviral ability of 25HC (25-Hydroxycholesterol) is uncovered due...