fMRI reveals that non-local processing in ventral retinotopic cortex underlies perceptual grouping by temporal synchrony

• Published in: Human brain mapping Vol. 29; no. 6; pp. 651 - 661
• Main Authors: Caplovitz, Gideon P., Barroso, Diego J., Hsieh, Po-Jang, Tse, Peter U.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.06.2008; Wiley-Liss
• Subjects: Biological and medical sciences; Brain Mapping; feedback; Fixation, Ocular - physiology; fMRI; form; Form Perception - physiology; Fundamental and applied biological sciences. Psychology; Humans; Investigative techniques, diagnostic techniques (general aspects); Language; Linear Models; Magnetic Resonance Imaging; Medical sciences; Miscellaneous; Models, Neurological; Nervous system; Photic Stimulation; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Reaction Time - physiology; retinotopic cortex; Time Perception - physiology; top-down processing; Visual Cortex - physiology; Visual Fields - physiology; feedback; fMRI; top-down processing; Nervous system diseases; Radiodiagnosis; form; retinotopic cortex; Nuclear magnetic resonance imaging
• ISSN: 1065-9471; 1097-0193; 1097-0193
• DOI: 10.1002/hbm.20429

When spatially separated objects appear and disappear in a synchronous manner, they perceptually group into a single global object that itself appears and disappears. We employed functional magnetic resonance imaging (fMRI) to identify brain regions involved in this type of perceptual grouping. Subjects viewed four chromatically‐defined disks (one per visual quadrant) that flashed on and off. We contrasted %BOLD signal changes between blocks of synchronously flashing disks (Grouping) with blocks of asynchronously flashing disks (no‐Grouping). Results: A region of interest analysis revealed %BOLD signal change in the Grouping condition was significantly greater than in the no‐Grouping condition within retinotopic areas V2, V3, and V4v. Within a single quadrant of the visual field, the spatio‐temporal information present in the image was identical across the two stimulus conditions. As such, the two conditions could not be distinguished from each other on the basis of the rate or pattern of flashing within a single visual quadrant. The observed results must therefore arise through nonlocal interactions between or within these retinotopic areas, or arise from outside these retinotopic areas. Furthermore, when V2 and V3 were split into ventral and dorsal sub‐ROIs, ventral retinotopic areas V2v and V3v preferentially differentiated between the two conditions whereas the corresponding dorsal areas V2d and V3d did not. In contrast, within hMT+, %BOLD signal was significantly greater in the no‐Grouping condition. Conclusion: Nonlocal processing within, between, or to ventral retinotopic cortex at least as early as V2v, and including V3v, and V4v, underlies perceptual grouping via temporal synchrony. Hum Brain Mapp, 2008. © 2007 Wiley‐Liss, Inc.