Actin-related protein Arp4 regulates euchromatic gene expression and development through H2A.Z deposition in blood-stage Plasmodium falciparum

• Published in: Parasites & vectors Vol. 13; no. 1; p. 314
• Main Authors: Liu, Hui, Cui, Xin-Yu, Xu, Dan-Dan, Wang, Fei, Meng, Lin-Wen, Zhao, Yue-Meng, Liu, Meng, Shen, Shi-Jun, He, Xiao-Hui, Fang, Qiang, Tao, Zhi-Yong, Jiang, Ci-Zong, Zhang, Qing-Feng, Gu, Liang, Xia, Hui
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.06.2020; BioMed Central; BMC
• Subjects: Actin; Analysis; Antibodies; Antimalarial agents; Antimalarials; Arp4; Bioinformatics; Blood; Catalytic RNA; Cell cycle; Cell Cycle - genetics; Cell Nucleus - metabolism; Centromere - genetics; Centromere - metabolism; Chromatin structure; Cloning; CRISPR; Deoxyribonucleic acid; Depletion; Deposition; Developmental stages; DNA; DNA methylation; DNA, Intergenic; Epigenesis, Genetic; Epigenetic inheritance; Epigenetics; Erythrocytes; Euchromatin - genetics; Euchromatin - metabolism; Gene editing; Gene expression; Gene Expression Regulation, Developmental; Gene regulation; Genes; Genetic engineering; Genomes; Glucosamine; Growth curves; Health aspects; Health risks; Histone H2A; Histones; Histones - genetics; Histones - metabolism; Human diseases; Life Cycle Stages - genetics; Malaria; Microfilament Proteins - genetics; Microfilament Proteins - metabolism; Muscle proteins; Nucleic acids; Parasites; Plasmodium falciparum; Plasmodium falciparum - genetics; Plasmodium falciparum - growth & development; Plasmodium falciparum - physiology; Promoter Regions, Genetic; Protein Binding; Proteins; Protozoan Proteins - genetics; Protozoan Proteins - metabolism; Public health; Regions; Regulatory mechanisms (biology); Ribonucleic acid; RNA; Transcription; Transcription (Genetics); Vector-borne diseases; United Kingdom > UK; United States > US; Plasmodium falciparum; Arp4; Malaria; Gene regulation; Chromatin structure

Malaria caused by Plasmodium spp. is still a major threat to public health globally. The various approaches to developing new antimalarial agents rely on the understanding of the complex regulatory mechanisms of dynamic gene expression in the life-cycle of these malaria parasites. The nuclear member...