Use of ECG Restitution (Beat-to-Beat QT-TQ Interval Analysis) to Assess Arrhythmogenic Risk of QTc Prolongation with Guanfacine

• Published in: Annals of noninvasive electrocardiology Vol. 19; no. 6; pp. 582 - 594
• Main Authors: Fossa, Anthony A., Zhou, Meijian, Robinson, Antoine, Purkayastha, Jaideep, Martin, Patrick
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.11.2014; John Wiley & Sons, Inc; John Wiley and Sons Inc
• Subjects: Adrenergic alpha-2 Receptor Agonists - pharmacology; arrhythmia; Arrhythmias, Cardiac - chemically induced; Attention Deficit Hyperactivity Disorder; beat-to-beat; Cardiac Safety; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug therapy; Electrocardiography, Ambulatory - drug effects; Electrocardiography, Ambulatory - methods; Female; Fluoroquinolones - administration & dosage; guanfacine; Guanfacine - pharmacology; Humans; Long QT Syndrome - chemically induced; Male; Moxifloxacin; QTc/QT prolongation; Reference Values; Restitution; Retrospective Studies; risk assessment; Risk Assessment - methods; QTc/QT prolongation; risk assessment; beat-to-beat; restitution; guanfacine; arrhythmia

Background Guanfacine (Intuniv) is a centrally active alpha‐2A adrenergic agonist for the new indication of attention‐deficit/hyperactivity disorder. QTc (QTcF and QTcNi) was prolonged at both therapeutic (4 mg) and supratherapeutic (8 mg) doses of a thorough QT study even though guanfacine has had...