Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling

• Published in: The EMBO journal Vol. 25; no. 6; pp. 1242 - 1252
• Main Authors: Georgakopoulos, Anastasios, Litterst, Claudia, Ghersi, Enrico, Baki, Lia, Xu, ChiJie, Serban, Geo, Robakis, Nikolaos K
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 22.03.2006; Blackwell Publishing Ltd
• Subjects: Adaptor Proteins, Signal Transducing - metabolism; Alzheimer's disease; Animals; Cells, Cultured; CSK Tyrosine-Protein Kinase; Enzymes; Ephrin-B2 - metabolism; ephrinB; Fibroblasts - cytology; Fibroblasts - metabolism; Genes, Dominant; Humans; Kidney - cytology; Kidney - metabolism; Membrane Proteins - antagonists & inhibitors; Membrane Proteins - genetics; Membrane Proteins - physiology; Metalloproteases - metabolism; Mice; Mice, Knockout; Nervous system; Oncogene Proteins - metabolism; Peptides; Phosphorylation; Phosphotransferases - metabolism; Presenilin-1; presenilin1; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins - metabolism; Proto-Oncogene Proteins pp60(c-src) - metabolism; Receptor, EphB2 - metabolism; Signal Transduction; Src kinase; src-Family Kinases; γ-secretase

Bidirectional signaling triggered by interacting ephrinB receptors (EphB) and ephrinB ligands is crucial for development and function of the vascular and nervous systems. A signaling cascade triggered by this interaction involves activation of Src kinase and phosphorylation of ephrinB. The mechanism...