Genome-Wide Association Study of Loneliness Demonstrates a Role for Common Variation

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 42; no. 4; pp. 811 - 821
• Main Authors: Gao, Jianjun, Davis, Lea K, Hart, Amy B, Sanchez-Roige, Sandra, Han, Lide, Cacioppo, John T, Palmer, Abraham A
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.03.2017
• Subjects: Adults; Aged; Depression - genetics; Estimates; Extraversion (Psychology); Female; Genes; Genome-Wide Association Study; Genomes; Humans; Loneliness; Longitudinal studies; Male; Mental Disorders - genetics; Middle Aged; Mortality; Neuroticism; Original; Phenotype; Social isolation; Twins; La Jolla California; Chicago Illinois; California; United States > US

Loneliness is a complex biological trait that has been associated with numerous negative health outcomes. The measurement and environmental determinants of loneliness are well understood, but its genetic basis is not. Previous studies have estimated the heritability of loneliness between 37 and 55%...