Discovery of facile amides-functionalized rhodanine-3-acetic acid derivatives as potential anticancer agents by disrupting microtubule dynamics

• Published in: Journal of enzyme inhibition and medicinal chemistry Vol. 36; no. 1; pp. 1996 - 2009
• Main Authors: Zhou, Xiang, Liu, Jiamin, Meng, Jiao, Fu, Yihong, Wu, Zhibin, Ouyang, Guiping, Wang, Zhenchao
• Format: Journal Article
• Language: English
• Published: ABINGDON Taylor & Francis 01.01.2021; Taylor & Francis Group
• Subjects: antiproliferative activity; Biochemistry & Molecular Biology; Chemistry, Medicinal; Life Sciences & Biomedicine; Microtubule; Pharmacology & Pharmacy; Research Paper; Science & Technology; taxol binding domains; tubulin stabiliser; TARGET; MIGRATION; APOPTOSIS; taxol binding domains; DESIGN; tubulin stabiliser; TUBULIN POLYMERIZATION; ANTITUMOR-ACTIVITY; CANCER; antiproliferative activity; BIOLOGICAL EVALUATION; Microtubule; INHIBITORS; BINDING

Microtubule dynamics are crucial for multiple cell functions, and cancer cells are particularly sensitive to microtubule-modulating agents. Here, we describe the design and synthesis of a series of (Z)-2-(5-benzylidene-4-oxo-2-thioxothiazolidin-3-yl)-N-phenylacetamide derivatives and evaluation of t...