Lipid-Lowering and Antioxidant Functions of Bottle Gourd (Lagenaria siceraria) Extract in Human Dyslipidemia
The study validated the antidyslipidemic, antioxidant, and antihyperglycemic effects of Lagenaria siceraria fruit extract in human subjects with dyslipidemia along with subjects of normal health. A total of 200 mL of freshly prepared Lagenaria siceraria fruit extract was administered daily on empty...
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| Published in | Journal of evidence-based complementary & alternative medicine Vol. 19; no. 2; pp. 112 - 118 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Los Angeles, CA
SAGE Publications
01.04.2014
SAGE Publishing |
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| Online Access | Get full text |
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| Abstract | The study validated the antidyslipidemic, antioxidant, and antihyperglycemic effects of Lagenaria siceraria fruit extract in human subjects with dyslipidemia along with subjects of normal health. A total of 200 mL of freshly prepared Lagenaria siceraria fruit extract was administered daily on empty stomach for 90 days. Significant reductions (P < .01) were found in triglycerides and total cholesterol levels in blood. Cardiac risk ratio, atherogenic coefficient, and atherogenicity index of plasma were also improved. Appreciable reductions in body mass index (P < .01) and blood pressure (systolic P < .01, diastolic P < .05) along with a significant reduction (P < .05) in fasting blood glucose levels were also observed in these subjects. Lagenaria siceraria fruit extract exhibited significant antioxidant activity in dyslipidemic subjects as evident from elevations in SOD (P < .05) and GSH levels (P < .01) with marked improvement in catalase (P < .01) and TBARS levels (P < .05). Phytochemical screening confirmed the presence of saponins, glycosides, flavonoids, terpenoids, and phenolic compounds. Lagenaria siceraria fruit extract serves as dietary adjunct in treatment of human dyslipidemia and cardiovascular disease. |
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| AbstractList | The study validated the antidyslipidemic, antioxidant, and antihyperglycemic effects of Lagenaria siceraria fruit extract in human subjects with dyslipidemia along with subjects of normal health. A total of 200 mL of freshly prepared Lagenaria siceraria fruit extract was administered daily on empty stomach for 90 days. Significant reductions ( P < .01) were found in triglycerides and total cholesterol levels in blood. Cardiac risk ratio, atherogenic coefficient, and atherogenicity index of plasma were also improved. Appreciable reductions in body mass index ( P < .01) and blood pressure (systolic P < .01, diastolic P < .05) along with a significant reduction ( P < .05) in fasting blood glucose levels were also observed in these subjects. Lagenaria siceraria fruit extract exhibited significant antioxidant activity in dyslipidemic subjects as evident from elevations in SOD ( P < .05) and GSH levels ( P < .01) with marked improvement in catalase ( P < .01) and TBARS levels ( P < .05). Phytochemical screening confirmed the presence of saponins, glycosides, flavonoids, terpenoids, and phenolic compounds. Lagenaria siceraria fruit extract serves as dietary adjunct in treatment of human dyslipidemia and cardiovascular disease. The study validated the antidyslipidemic, antioxidant, and antihyperglycemic effects of Lagenaria siceraria fruit extract in human subjects with dyslipidemia along with subjects of normal health. A total of 200 mL of freshly prepared Lagenaria siceraria fruit extract was administered daily on empty stomach for 90 days. Significant reductions (P < .01) were found in triglycerides and total cholesterol levels in blood. Cardiac risk ratio, atherogenic coefficient, and atherogenicity index of plasma were also improved. Appreciable reductions in body mass index (P < .01) and blood pressure (systolic P < .01, diastolic P < .05) along with a significant reduction (P < .05) in fasting blood glucose levels were also observed in these subjects. Lagenaria siceraria fruit extract exhibited significant antioxidant activity in dyslipidemic subjects as evident from elevations in SOD (P < .05) and GSH levels (P < .01) with marked improvement in catalase (P < .01) and TBARS levels (P < .05). Phytochemical screening confirmed the presence of saponins, glycosides, flavonoids, terpenoids, and phenolic compounds. Lagenaria siceraria fruit extract serves as dietary adjunct in treatment of human dyslipidemia and cardiovascular disease.The study validated the antidyslipidemic, antioxidant, and antihyperglycemic effects of Lagenaria siceraria fruit extract in human subjects with dyslipidemia along with subjects of normal health. A total of 200 mL of freshly prepared Lagenaria siceraria fruit extract was administered daily on empty stomach for 90 days. Significant reductions (P < .01) were found in triglycerides and total cholesterol levels in blood. Cardiac risk ratio, atherogenic coefficient, and atherogenicity index of plasma were also improved. Appreciable reductions in body mass index (P < .01) and blood pressure (systolic P < .01, diastolic P < .05) along with a significant reduction (P < .05) in fasting blood glucose levels were also observed in these subjects. Lagenaria siceraria fruit extract exhibited significant antioxidant activity in dyslipidemic subjects as evident from elevations in SOD (P < .05) and GSH levels (P < .01) with marked improvement in catalase (P < .01) and TBARS levels (P < .05). Phytochemical screening confirmed the presence of saponins, glycosides, flavonoids, terpenoids, and phenolic compounds. Lagenaria siceraria fruit extract serves as dietary adjunct in treatment of human dyslipidemia and cardiovascular disease. The study validated the antidyslipidemic, antioxidant, and antihyperglycemic effects of Lagenariasiceraria fruit extract in human subjects with dyslipidemia along with subjects of normal health. A total of 200 mL of freshly prepared Lagenariasiceraria fruit extract was administered daily on empty stomach for 90 days. Significant reductions (P < .01) were found in triglycerides and total cholesterol levels in blood. Cardiac risk ratio, atherogenic coefficient, and atherogenicity index of plasma were also improved. Appreciable reductions in body mass index (P < .01) and blood pressure (systolic P < .01, diastolic P < .05) along with a significant reduction (P < .05) in fasting blood glucose levels were also observed in these subjects. Lagenariasiceraria fruit extract exhibited significant antioxidant activity in dyslipidemic subjects as evident from elevations in SOD (P < .05) and GSH levels (P < .01) with marked improvement in catalase (P < .01) and TBARS levels (P < .05). Phytochemical screening confirmed the presence of saponins, glycosides, flavonoids, terpenoids, and phenolic compounds. Lagenariasiceraria fruit extract serves as dietary adjunct in treatment of human dyslipidemia and cardiovascular disease. The study validated the antidyslipidemic, antioxidant, and antihyperglycemic effects of Lagenariasiceraria fruit extract in human subjects with dyslipidemia along with subjects of normal health. A total of 200 mL of freshly prepared Lagenariasiceraria fruit extract was administered daily on empty stomach for 90 days. Significant reductions (P < .01) were found in triglycerides and total cholesterol levels in blood. Cardiac risk ratio, atherogenic coefficient, and atherogenicity index of plasma were also improved. Appreciable reductions in body mass index (P < .01) and blood pressure (systolic P < .01, diastolic P < .05) along with a significant reduction (P < .05) in fasting blood glucose levels were also observed in these subjects. Lagenariasiceraria fruit extract exhibited significant antioxidant activity in dyslipidemic subjects as evident from elevations in SOD (P < .05) and GSH levels (P < .01) with marked improvement in catalase (P < .01) and TBARS levels (P < .05). Phytochemical screening confirmed the presence of saponins, glycosides, flavonoids, terpenoids, and phenolic compounds. Lagenariasiceraria fruit extract serves as dietary adjunct in treatment of human dyslipidemia and cardiovascular disease. Adapted from source document |
| Author | Katare, Charu Bisen, Prakash Singh Joseph, Anish Zacharia Prasad, G. B. K. S. Saxena, Sonali Agrawal, Supriya Yadav, Dhananjay Singh, Nita Subramani, Senthil Kumar |
| Author_xml | – sequence: 1 givenname: Charu surname: Katare fullname: Katare, Charu email: cskatare@gmail.com – sequence: 2 givenname: Sonali surname: Saxena fullname: Saxena, Sonali – sequence: 3 givenname: Supriya surname: Agrawal fullname: Agrawal, Supriya – sequence: 4 givenname: Anish Zacharia surname: Joseph fullname: Joseph, Anish Zacharia – sequence: 5 givenname: Senthil Kumar surname: Subramani fullname: Subramani, Senthil Kumar – sequence: 6 givenname: Dhananjay surname: Yadav fullname: Yadav, Dhananjay – sequence: 7 givenname: Nita surname: Singh fullname: Singh, Nita – sequence: 8 givenname: Prakash Singh surname: Bisen fullname: Bisen, Prakash Singh – sequence: 9 givenname: G. B. K. S. surname: Prasad fullname: Prasad, G. B. K. S. |
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| Cites_doi | 10.1161/circ.106.25.3143 10.1016/j.freeradbiomed.2007.12.029 10.1373/clinchem.2004.037556 10.4103/0971-5916.93424 10.3923/pjn.2006.79.82 10.1007/s11745-997-0138-5 10.2337/diab.39.11.1420 10.5138/ijaps.2010.0976.1055.01005 10.1016/0003-2697(72)90132-7 10.1373/clinchem.2003.022558 10.1016/j.jep.2003.09.022 10.1016/S0140-6736(03)14234-1 10.1093/clinchem/23.5.882 10.4103/0250-474X.39441 10.4314/thrb.v11i2.45206 10.1016/0003-9861(59)90090-6 10.1093/clinchem/28.10.2077 10.1093/clinchem/18.6.499 10.2165/00129784-200808040-00004 10.1001/jama.282.21.2043 10.1016/0003-2697(79)90738-3 10.1021/np9904509 10.1016/S0002-9149(98)00035-6 10.3109/00365516009065404 10.4103/0975-9476.74431 |
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| References | Ohkawa, Ohishi, Yagi 1979; 95 Sinha 1972; 47 Sharma 2004; 90 Kolovou, Kostakou, Anagnostopoulou, Cokkinos 2008; 8 Pier 2000; 63 Sharma, Puri, Jain 2012; 135 Stockbrige, Glueck 1989; 114 Ghule, Ghante, Yeole, Saoji 2007; 69 Frohlich, Dobiásová 2003; 49 Raobdo, Terkildsen 1960; 12 Usoro, Nsonwu 2006; 5 Durrington 2003; 362 Erasto, Mbwambo 2009; 11 Fossati, Prencipe 1982; 28 Mali, Bodhankar 2010; 1 Hunt, Smith, Wolff 1990; 39 Steinberg, Gotto 1999; 282 Mantena, King, Andringa, Eccleston, Bailey 2008; 44 Fukushima, Matsuda, Yamagishi, Nakano 1997; 32 Deshpande, Choudhari, Mishra, Meghre, Wadodkar, Dorale 2008; 46 Henry, Ginsberg 1998; 81 Lopes-Virella, Stone, Ellis, Colwell 1977; 23 2002; 106 Friedewald, Levy, Friedrickson 1972; 18 Brehm, Pfeiler, Pacini, Vierhapper, Roden 2004; 50 Milind, Kaur 2011; 2 Shirwaikar, Sreenivasan 1996; 58 Ellman 1959; 82 Winterbourn, Hawkins, Brian, Carrell 1975; 85 Prajapati, Kalariya, Parmar, Sheth 2010; 1 bibr33-2156587214524229 bibr20-2156587214524229 Stockbrige H (bibr13-2156587214524229) 1989; 114 bibr25-2156587214524229 bibr3-2156587214524229 Harbone JB (bibr22-2156587214524229) 1998 bibr7-2156587214524229 bibr12-2156587214524229 bibr29-2156587214524229 Deshpande JR (bibr6-2156587214524229) 2008; 46 bibr16-2156587214524229 Shirwaikar A (bibr8-2156587214524229) 1996; 58 bibr21-2156587214524229 bibr26-2156587214524229 bibr34-2156587214524229 bibr17-2156587214524229 Brunzell JD (bibr4-2156587214524229) 1995 Milind P (bibr27-2156587214524229) 2011; 2 bibr30-2156587214524229 bibr14-2156587214524229 bibr5-2156587214524229 bibr35-2156587214524229 bibr31-2156587214524229 bibr9-2156587214524229 bibr15-2156587214524229 bibr2-2156587214524229 bibr10-2156587214524229 bibr28-2156587214524229 bibr23-2156587214524229 bibr24-2156587214524229 bibr1-2156587214524229 bibr11-2156587214524229 Winterbourn CC (bibr18-2156587214524229) 1975; 85 bibr32-2156587214524229 bibr19-2156587214524229 |
| References_xml | – volume: 114 start-page: 142 year: 1989 end-page: 151 article-title: Public cholesterol screening: motivation for participation, follow-up outcome, self-knowledge and coronary heart disease risk factor intervention publication-title: J Lab Clin Med – volume: 47 start-page: 389 year: 1972 end-page: 394 article-title: Colorimetric assay of catalase publication-title: Anal Biochem – volume: 81 start-page: 32B issue: 4 year: 1998 end-page: 35B article-title: Effects of statins on triglyceride metabolism publication-title: Am J Cardiol – volume: 12 start-page: 402 year: 1960 end-page: 407 article-title: On the enzymatic determination of blood glucose publication-title: Scand J Clin Lab Invest – volume: 5 start-page: 79 year: 2006 end-page: 82 article-title: Lipid profile of postmenopausal women in Calabar, Nigeria publication-title: Pak J Nutr – volume: 23 start-page: 882 year: 1977 end-page: 883 article-title: Cholesterol determination in high-density lipoproteins separated by three different methods publication-title: Clin Chem – volume: 50 start-page: 2316 year: 2004 end-page: 2322 article-title: Relationship between serum lipoprotein ratios and insulin resistance in obesity publication-title: Clin Chem – volume: 69 start-page: 817 year: 2007 end-page: 819 article-title: Diuretic activity of fruit extract in rats publication-title: Indian J Pharm Sci – volume: 362 start-page: 717 year: 2003 end-page: 731 article-title: Dyslipidemia publication-title: Lancet – volume: 8 start-page: 243 year: 2008 end-page: 255 article-title: Therapeutic effects of fibrates in postprandial lipemia publication-title: Am J Cardiovasc Drugs – volume: 2 start-page: 13 issue: 6 year: 2011 end-page: 17 article-title: Is bottle gourd a natural guard? publication-title: Int Res J Pharm – volume: 28 start-page: 2077 year: 1982 end-page: 2080 article-title: Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide publication-title: Clin Chem – volume: 95 start-page: 351 year: 1979 end-page: 358 article-title: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction publication-title: Anal Biochem – volume: 11 start-page: 79 issue: 2 year: 2009 end-page: 83 article-title: Antioxidant activity and HPTLC profile of fruits publication-title: Tanzania J Health Res – volume: 1 start-page: 50 year: 2010 end-page: 53 article-title: Effect of (LS) powder on dexamethasone induced hypertension in rats publication-title: Int J Adv Pharm Sci – volume: 46 start-page: 234 year: 2008 end-page: 242 article-title: Beneficial effect of (Mol.) Standly fruit epicarp in animal models publication-title: Indian J Exp Biol – volume: 82 start-page: 70 year: 1959 end-page: 77 article-title: Tissue sulfhydryl groups publication-title: Arch Biochem – volume: 32 start-page: 1069 year: 1997 end-page: 1074 article-title: Comparative hypocholesterolemic effects of six dietary oils in cholesterol-fed rats after long-term feeding publication-title: Lipids – volume: 135 start-page: 49 year: 2012 end-page: 55 article-title: Assessment of effects on health due to consumption of bitter bottle gourd ( ) juice publication-title: Indian J Med Res – volume: 90 start-page: 63 year: 2004 end-page: 68 article-title: Hypolipidemic effect of different extracts of Walp in normal and high-fat diet fed rats publication-title: J Ethnopharmacol – volume: 49 start-page: 1873 year: 2003 end-page: 1880 article-title: Fractional esterification rate of cholesterol and ratio of triglycerides to HDL-cholesterol are powerful predictors of positive findings on coronary angiography publication-title: Clin Chem – volume: 63 start-page: 1035 year: 2000 end-page: 1042 article-title: Flavonoids as antioxidants publication-title: J Nat Prod – volume: 58 start-page: 197 year: 1996 article-title: Chemical investigation and antihepatotoxic activity of the fruit of publication-title: Indian J Pharm Sci – volume: 18 start-page: 499 year: 1972 end-page: 502 article-title: Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge publication-title: Clin Chem – volume: 1 start-page: 266 year: 2010 end-page: 272 article-title: Phytochemical and pharmacological review of publication-title: J Ayurveda Integr Med – volume: 282 start-page: 2043 year: 1999 end-page: 2050 article-title: Preventing coronary artery disease by lowering cholesterol levels: fifty years from bench to bedside publication-title: JAMA – volume: 85 start-page: 337 year: 1975 end-page: 341 article-title: Estimation of red cell superoxide dismutase activity publication-title: J Lab Clin Med – volume: 39 start-page: 1420 year: 1990 end-page: 1424 article-title: Autoxidation glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucose publication-title: Diabetes – volume: 106 start-page: 3143 year: 2002 end-page: 3421 article-title: Third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report publication-title: Circulation – volume: 44 start-page: 1259 year: 2008 end-page: 1272 article-title: Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol and obesity-induced fatty liver diseases publication-title: Free Radic Biol Med – ident: bibr9-2156587214524229 doi: 10.1161/circ.106.25.3143 – ident: bibr31-2156587214524229 doi: 10.1016/j.freeradbiomed.2007.12.029 – ident: bibr16-2156587214524229 doi: 10.1373/clinchem.2004.037556 – volume-title: Phytochemical Methods: A Guide to Modern Techniques of Plant Analysis year: 1998 ident: bibr22-2156587214524229 – volume: 58 start-page: 197 year: 1996 ident: bibr8-2156587214524229 publication-title: Indian J Pharm Sci – ident: bibr10-2156587214524229 doi: 10.4103/0971-5916.93424 – ident: bibr28-2156587214524229 doi: 10.3923/pjn.2006.79.82 – ident: bibr25-2156587214524229 doi: 10.1007/s11745-997-0138-5 – ident: bibr2-2156587214524229 doi: 10.2337/diab.39.11.1420 – ident: bibr35-2156587214524229 doi: 10.5138/ijaps.2010.0976.1055.01005 – ident: bibr19-2156587214524229 doi: 10.1016/0003-2697(72)90132-7 – ident: bibr33-2156587214524229 – ident: bibr17-2156587214524229 doi: 10.1373/clinchem.2003.022558 – volume: 2 start-page: 13 issue: 6 year: 2011 ident: bibr27-2156587214524229 publication-title: Int Res J Pharm – ident: bibr26-2156587214524229 doi: 10.1016/j.jep.2003.09.022 – ident: bibr1-2156587214524229 doi: 10.1016/S0140-6736(03)14234-1 – volume: 46 start-page: 234 year: 2008 ident: bibr6-2156587214524229 publication-title: Indian J Exp Biol – ident: bibr14-2156587214524229 doi: 10.1093/clinchem/23.5.882 – ident: bibr34-2156587214524229 doi: 10.4103/0250-474X.39441 – ident: bibr29-2156587214524229 doi: 10.4314/thrb.v11i2.45206 – ident: bibr20-2156587214524229 doi: 10.1016/0003-9861(59)90090-6 – ident: bibr12-2156587214524229 doi: 10.1093/clinchem/28.10.2077 – ident: bibr15-2156587214524229 doi: 10.1093/clinchem/18.6.499 – start-page: 1913 volume-title: The Metabolic and Molecular Bases of Inherited Disease year: 1995 ident: bibr4-2156587214524229 – ident: bibr5-2156587214524229 doi: 10.2165/00129784-200808040-00004 – volume: 85 start-page: 337 year: 1975 ident: bibr18-2156587214524229 publication-title: J Lab Clin Med – ident: bibr30-2156587214524229 doi: 10.1001/jama.282.21.2043 – ident: bibr21-2156587214524229 doi: 10.1016/0003-2697(79)90738-3 – volume: 114 start-page: 142 year: 1989 ident: bibr13-2156587214524229 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| Title | Lipid-Lowering and Antioxidant Functions of Bottle Gourd (Lagenaria siceraria) Extract in Human Dyslipidemia |
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