Toxicity and possible mechanisms of action of honokiol from Magnolia denudata seeds against four mosquito species

This study was performed to determine the toxicity and possible mechanism of the larvicidal action of honokiol, extracted from Magnolia denudata seeds, and its 10 related compounds against third-instar larvae of insecticide-susceptible Culex pipiens pallens , Aedes aegypti , and Aedes albopictus and...

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Published inScientific reports Vol. 9; no. 1; p. 411
Main Authors Wang, Zhangqian, Perumalsamy, Haribalan, Wang, Xue, Ahn, Young-Joon
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 23.01.2019
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Abstract This study was performed to determine the toxicity and possible mechanism of the larvicidal action of honokiol, extracted from Magnolia denudata seeds, and its 10 related compounds against third-instar larvae of insecticide-susceptible Culex pipiens pallens , Aedes aegypti , and Aedes albopictus and Anopheles sinensis resistant to deltamethrin and temephos. Honokiol (LC 50 , 6.13–7.37 mg/L) was highly effective against larvae of all of the four mosquito species, although the toxicity of the compound was lower than that of the synthetic larvicide temephos. Structure–activity relationship analyses indicated that electron donor and/or bulky groups at the ortho or para positions of the phenol were required for toxicity. Honokiol moderately inhibited acetylcholinesterase and caused a considerable increase in cyclic AMP levels, indicating that it might act on both acetylcholinesterase and octopaminergic receptors. Microscopy analysis clearly indicated that honokiol was mainly targeted to the midgut epithelium and anal gills, resulting in variably dramatic degenerative responses of the midgut through sequential epithelial disorganization. Honokiol did not affect the AeCS1 mRNA expression level in Ae . aegypti larvae, but did enhance expression of the genes encoding vacuolar-type H + -ATPase and aquaporin 4, indicating that it may disturb the Na + , Cl − and K + co-transport systems. These results demonstrate that honokiol merits further study as a potential larvicide, with a specific target site, and as a lead molecule for the control of mosquito populations.
AbstractList This study was performed to determine the toxicity and possible mechanism of the larvicidal action of honokiol, extracted from Magnolia denudata seeds, and its 10 related compounds against third-instar larvae of insecticide-susceptible Culex pipiens pallens , Aedes aegypti , and Aedes albopictus and Anopheles sinensis resistant to deltamethrin and temephos. Honokiol (LC 50 , 6.13–7.37 mg/L) was highly effective against larvae of all of the four mosquito species, although the toxicity of the compound was lower than that of the synthetic larvicide temephos. Structure–activity relationship analyses indicated that electron donor and/or bulky groups at the ortho or para positions of the phenol were required for toxicity. Honokiol moderately inhibited acetylcholinesterase and caused a considerable increase in cyclic AMP levels, indicating that it might act on both acetylcholinesterase and octopaminergic receptors. Microscopy analysis clearly indicated that honokiol was mainly targeted to the midgut epithelium and anal gills, resulting in variably dramatic degenerative responses of the midgut through sequential epithelial disorganization. Honokiol did not affect the AeCS1 mRNA expression level in Ae . aegypti larvae, but did enhance expression of the genes encoding vacuolar-type H + -ATPase and aquaporin 4, indicating that it may disturb the Na + , Cl − and K + co-transport systems. These results demonstrate that honokiol merits further study as a potential larvicide, with a specific target site, and as a lead molecule for the control of mosquito populations.
This study was performed to determine the toxicity and possible mechanism of the larvicidal action of honokiol, extracted from Magnolia denudata seeds, and its 10 related compounds against third-instar larvae of insecticide-susceptible Culex pipiens pallens, Aedes aegypti, and Aedes albopictus and Anopheles sinensis resistant to deltamethrin and temephos. Honokiol (LC50, 6.13–7.37 mg/L) was highly effective against larvae of all of the four mosquito species, although the toxicity of the compound was lower than that of the synthetic larvicide temephos. Structure–activity relationship analyses indicated that electron donor and/or bulky groups at the ortho or para positions of the phenol were required for toxicity. Honokiol moderately inhibited acetylcholinesterase and caused a considerable increase in cyclic AMP levels, indicating that it might act on both acetylcholinesterase and octopaminergic receptors. Microscopy analysis clearly indicated that honokiol was mainly targeted to the midgut epithelium and anal gills, resulting in variably dramatic degenerative responses of the midgut through sequential epithelial disorganization. Honokiol did not affect the AeCS1 mRNA expression level in Ae. aegypti larvae, but did enhance expression of the genes encoding vacuolar-type H+-ATPase and aquaporin 4, indicating that it may disturb the Na+, Cl− and K+ co-transport systems. These results demonstrate that honokiol merits further study as a potential larvicide, with a specific target site, and as a lead molecule for the control of mosquito populations.
This study was performed to determine the toxicity and possible mechanism of the larvicidal action of honokiol, extracted from Magnolia denudata seeds, and its 10 related compounds against third-instar larvae of insecticide-susceptible Culex pipiens pallens, Aedes aegypti, and Aedes albopictus and Anopheles sinensis resistant to deltamethrin and temephos. Honokiol (LC , 6.13-7.37 mg/L) was highly effective against larvae of all of the four mosquito species, although the toxicity of the compound was lower than that of the synthetic larvicide temephos. Structure-activity relationship analyses indicated that electron donor and/or bulky groups at the ortho or para positions of the phenol were required for toxicity. Honokiol moderately inhibited acetylcholinesterase and caused a considerable increase in cyclic AMP levels, indicating that it might act on both acetylcholinesterase and octopaminergic receptors. Microscopy analysis clearly indicated that honokiol was mainly targeted to the midgut epithelium and anal gills, resulting in variably dramatic degenerative responses of the midgut through sequential epithelial disorganization. Honokiol did not affect the AeCS1 mRNA expression level in Ae. aegypti larvae, but did enhance expression of the genes encoding vacuolar-type H -ATPase and aquaporin 4, indicating that it may disturb the Na , Cl and K co-transport systems. These results demonstrate that honokiol merits further study as a potential larvicide, with a specific target site, and as a lead molecule for the control of mosquito populations.
ArticleNumber 411
Author Wang, Xue
Wang, Zhangqian
Perumalsamy, Haribalan
Ahn, Young-Joon
Author_xml – sequence: 1
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  surname: Wang
  fullname: Wang, Zhangqian
  organization: Department of Agricultural Biotechnology, Seoul National University, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, and Wuhan University School of Pharmaceutical Sciences
– sequence: 2
  givenname: Haribalan
  surname: Perumalsamy
  fullname: Perumalsamy, Haribalan
  organization: Research Institute of Agriculture and Life Sciences, Seoul National University
– sequence: 3
  givenname: Xue
  surname: Wang
  fullname: Wang, Xue
  organization: School of Pharmaceutical Science, Wenzhou Medical University
– sequence: 4
  givenname: Young-Joon
  surname: Ahn
  fullname: Ahn, Young-Joon
  email: yjahn@snu.ac.kr
  organization: Department of Agricultural Biotechnology, Seoul National University, Research Institute of Agriculture and Life Sciences, Seoul National University
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Snippet This study was performed to determine the toxicity and possible mechanism of the larvicidal action of honokiol, extracted from Magnolia denudata seeds, and its...
This study was performed to determine the toxicity and possible mechanism of the larvicidal action of honokiol, extracted from Magnolia denudata seeds, and its...
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StartPage 411
SubjectTerms 101/58
101/6
13
13/51
38/77
631/45/880
631/61/185
82
82/58
82/80
96/34
96/63
Acetylcholinesterase
Aedes aegypti
Animals
Aquaporin 4
Aquatic insects
Biphenyl Compounds - chemistry
Biphenyl Compounds - pharmacokinetics
Biphenyl Compounds - pharmacology
Culicidae - metabolism
Cyclic AMP
Deltamethrin
Epithelium
Gene expression
Gills
H+-transporting ATPase
Humanities and Social Sciences
Insecticides
Insecticides - chemistry
Insecticides - pharmacokinetics
Insecticides - pharmacology
Larva - metabolism
Larvae
Larvicides
Lignans - chemistry
Lignans - pharmacokinetics
Lignans - pharmacology
Magnolia - chemistry
Magnolia denudata
Midgut
Mosquito Control
Mosquitoes
multidisciplinary
Octopamine
Phenols
Science
Science (multidisciplinary)
Seeds
Seeds - chemistry
Species Specificity
Toxicity
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Title Toxicity and possible mechanisms of action of honokiol from Magnolia denudata seeds against four mosquito species
URI https://link.springer.com/article/10.1038/s41598-018-36558-y
https://www.ncbi.nlm.nih.gov/pubmed/30674912
https://www.proquest.com/docview/2170389966
https://pubmed.ncbi.nlm.nih.gov/PMC6344527
Volume 9
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