NMDA Receptors in Retrosplenial Cortex Are Necessary for Retrieval of Recent and Remote Context Fear Memory

• Published in: The Journal of neuroscience Vol. 31; no. 32; pp. 11655 - 11659
• Main Authors: Corcoran, Kevin A., Donnan, Michael D., Tronson, Natalie C., Guzmán, Yomayra F., Gao, Can, Jovasevic, Vladimir, Guedea, Anita L., Radulovic, Jelena
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 10.08.2011
• Subjects: Animals; Brief Communications; Conditioning, Psychological - physiology; Excitatory Amino Acid Antagonists - pharmacology; Fear - drug effects; Fear - physiology; Male; Memory - drug effects; Memory - physiology; Memory, Long-Term - drug effects; Memory, Long-Term - physiology; Mice; Mice, Inbred C57BL; Neocortex - drug effects; Neocortex - physiology; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate - physiology

Over time, memory retrieval is thought to transfer from the hippocampus to a distributed network of neocortical sites. Of these sites, the retrosplenial cortex (RSC) is robustly activated during retrieval of remotely acquired, emotionally valenced memories. It is unclear, however, whether RSC is spe...