Aberrant Alternative Splicing Events in Parkinson's Disease

• Published in: Cell Transplantation Vol. 22; no. 4; pp. 653 - 661
• Main Authors: Fu, Ru-Huei, Liu, Shih-Ping, Huang, Shyh-Jer, Chen, Hung-Jen, Chen, Pin-Ru, Lin, Ya-Hsien, Ho, Yu-Chen, Chang, Wen-Lin, Tsai, Chang-Hai, Shyu, Woei-Cherng, Lin, Shinn-Zong
• Format: Book Review Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.04.2013; SAGE Publishing
• Subjects: Alternative Splicing - genetics; Animals; Humans; Parkinson Disease - diagnosis; Parkinson Disease - genetics; Parkinson Disease - therapy; Prognosis; Alternative splicing (AS); Trans-acting splicing factors; Cis-regulatory elements; Parkinson's disease (PD)

Alternative splicing (AS) using a sole gene to express multiple transcripts with diverse protein coding sequences and/or RNA regulatory elements raises genomic complexities. In the nervous system, several thousand AS events play important roles in ion transportation, receptor recognition, neurotrans...