Increased Plasma Plasminogen Activator Inhibitor-1 Levels: A Possible Marker of Hypertensive Target Organ Damage

• Published in: Clinical and experimental hypertension (1993) Vol. 25; no. 1; pp. 1 - 9
• Main Authors: Diamantopoulos, Emmanuel J., Andreadis, Emmanuel A., Vassilopoulos, Charalambos V., Theodorides, Theodoros G., Giannakopoulos, Nikolaos S., Chatzis, Nikolaos A., Christopoulou-Kokkinou, Vana D.
• Format: Journal Article
• Language: English
• Published: Colchester Informa UK Ltd 2003; Taylor & Francis
• Subjects: Adult; Aged; Albuminuria - urine; Antihypertensive agents; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Biomarkers - blood; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiovascular system; Carotid Arteries - diagnostic imaging; Carotid intima-media thickness; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Echocardiography; Female; Humans; Hypertension - blood; Hypertension - complications; Hypertension - diagnostic imaging; Hypertension - urine; Hypertrophy, Left Ventricular - diagnostic imaging; Hypertrophy, Left Ventricular - etiology; Left ventricular mass; Male; Medical sciences; Microalbuminuria; Middle Aged; Pharmacology. Drug treatments; Plasminogen Activator Inhibitor 1 - blood; Plasminogen activator inhibitor-1; Tunica Intima - diagnostic imaging; Tunica Media - diagnostic imaging; Human; Hypertension; Nervous system diseases; Stroke; Urinary system disease; Target organ; Albumin; Biological marker; Cardiovascular disease; Left ventricular mass; Plasminogen activator inhibitor-1; Coronary heart disease; Carotid intima- media thickness; Left ventricle; Cerebral disorder; Vascular disease; Plasminogen activator inhibitor 1; Chemotherapy; Carotid; Central nervous system disease; Antihypertensive agent; Cerebrovascular disease; Microalbuminuria; Proteinuria

High plasma plasminogen-activator inhibitor-1 (PAI-1) concentrations have been reported in coronary artery disease and stroke. We therefore, prospectively studied the association of PAI-1 with early target organ damage in patients with arterial hypertension has not been clearly established. We there...