Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock

• Published in: Cell Vol. 148; no. 1-2; pp. 46 - 57
• Main Authors: Rando, Thomas A., Chang, Howard Y.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.01.2012
• Subjects: Aging - genetics; Aging - pathology; Animals; Biological Clocks; epigenetics; Epigenomics; Gene Expression Regulation, Developmental; genotype-environment interaction; Humans; Rejuvenation; senescence (aging); tissues

The underlying cause of aging remains one of the central mysteries of biology. Recent studies in several different systems suggest that not only may the rate of aging be modified by environmental and genetic factors, but also that the aging clock can be reversed, restoring characteristics of youthfu...