Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock

The underlying cause of aging remains one of the central mysteries of biology. Recent studies in several different systems suggest that not only may the rate of aging be modified by environmental and genetic factors, but also that the aging clock can be reversed, restoring characteristics of youthfu...

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Bibliographic Details
Published inCell Vol. 148; no. 1-2; pp. 46 - 57
Main Authors Rando, Thomas A., Chang, Howard Y.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 20.01.2012
Subjects
Aging - genetics
Aging - pathology
Animals
Biological Clocks
epigenetics
Epigenomics
Gene Expression Regulation, Developmental
genotype-environment interaction
Humans
Rejuvenation
senescence (aging)
tissues
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Summary:The underlying cause of aging remains one of the central mysteries of biology. Recent studies in several different systems suggest that not only may the rate of aging be modified by environmental and genetic factors, but also that the aging clock can be reversed, restoring characteristics of youthfulness to aged cells and tissues. This Review focuses on the emerging biology of rejuvenation through the lens of epigenetic reprogramming. By defining youthfulness and senescence as epigenetic states, a framework for asking new questions about the aging process emerges.
Bibliography:http://dx.doi.org/10.1016/j.cell.2012.01.003
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ISSN:0092-8674
1097-4172
1097-4172
DOI:10.1016/j.cell.2012.01.003