Chronic intake of 4-Methylimidazole induces Hyperinsulinemia and Hypoglycaemia via Pancreatic Beta Cell Hyperplasia and Glucose Dyshomeostasis

• Published in: Scientific reports Vol. 8; no. 1; pp. 17037 - 13
• Main Authors: Rekha, Balakrishnan, Velmurugan, Ganesan, Freddy, Allen J., Anusha, Sivakumar, Ramprasath, Tharmarajan, Karthik, Karuppusamy V., Suresh, Shanmugarajan, Kulshrestha, Prerna, Mithieux, Gilles, Lyon, Alexander R., Selvam, Govindan Sadasivam, Ramasamy, Subbiah
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.11.2018; Nature Publishing Group
• Subjects: 13; 13/2; 13/51; 14/63; 38; 38/77; 631/45/776; 64; 692/163/2743; 82; 82/1; Animals; Apoptosis - drug effects; Beta cells; Beverages; Blood Glucose - metabolism; Caramel; Cholesterol; Diabetes mellitus; Endocrine disorders; Female; Food additives; Food Coloring Agents - administration & dosage; Food Coloring Agents - toxicity; Glucose; Homeostasis; Homeostasis - drug effects; Humanities and Social Sciences; Humans; Hyperinsulinemia; Hyperinsulinism - chemically induced; Hyperplasia; Hyperplasia - pathology; Hypoglycemia; Hypoglycemia - chemically induced; Imidazoles - administration & dosage; Imidazoles - toxicity; Insulin - blood; Insulin-Secreting Cells - metabolism; Insulin-Secreting Cells - pathology; Life Sciences; Lipid Metabolism - drug effects; Lipogenesis; Low density lipoprotein; Mice; Mice, Inbred BALB C; multidisciplinary; Neurons and Cognition; Neurotoxicity; Oxidative Stress - drug effects; Pancreatic cancer; Science; Science (multidisciplinary); Sweeteners; Triglycerides; Caramel Color; Soft Drink Consumers; Theoretical Maximum Daily Intake (TMDI); Intraperitoneal Insulin Tolerance Test; Increased Insulin Synthesis

Caramel colours are the preferential food colouring agent globally, reaches wide age groups through eatables. Colas, a sweetened carbonated drink are most common caramel coloured beverage and its consumption is linked with diabetes, obesity, pancreatic cancer and other endocrine disorders. A major b...