LPS-induced lung inflammation is linked to increased epithelial permeability: role of MLCK

• Published in: The European respiratory journal Vol. 25; no. 5; pp. 789 - 796
• Main Authors: Eutamene, H, Theodorou, V, Schmidlin, F, Tondereau, V, Garcia-Villar, R, Salvador-Cartier, C, Chovet, M, Bertrand, C, Bueno, L
• Format: Journal Article
• Language: English
• Published: Leeds Eur Respiratory Soc 01.05.2005; Maney; European Respiratory Society
• Subjects: Animals; Azepines - pharmacology; Biological and medical sciences; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors - pharmacology; Humans; Life Sciences; Lipopolysaccharides; Lung - enzymology; Male; Medical sciences; Myosin-Light-Chain Kinase - drug effects; Myosin-Light-Chain Kinase - metabolism; Naphthalenes - pharmacology; Permeability; Peroxidase - metabolism; Pneumology; Pneumonia - chemically induced; Pneumonia - enzymology; Rats; Rats, Wistar; Reference Values; Respiratory Mucosa - drug effects; Respiratory Mucosa - enzymology; Enzyme; Transferases; Lung; Lipopolysaccharide; Inflammation; Permeability; Airway epithelium; Epithelium; myosin light chain kinase; Myosin-light-chain kinase

The respiratory system is directly exposed to low levels of lipopolysaccharide (LPS), present as a contaminant on airborne particles. In cystic fibrosis, the prevailing data identify structural changes of the airway epithelium, as well as tight junction dilatation. This study was aimed at determinin...