Paracrine Mechanisms of Mesenchymal Stem Cell-Based Therapy: Current Status and Perspectives

• Published in: Cell transplantation Vol. 23; no. 9; pp. 1045 - 1059
• Main Authors: Liang, Xiaoting, Ding, Yue, Zhang, Yuelin, Tse, Hung-Fat, Lian, Qizhou
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.09.2014; SAGE Publishing
• Subjects: Angiogenesis Inducing Agents - metabolism; Antioxidants - metabolism; Cell- and Tissue-Based Therapy - trends; Humans; Immunologic Factors - metabolism; Mesenchymal Stem Cell Transplantation - trends; Mesenchymal Stromal Cells - cytology; Mesenchymal Stromal Cells - metabolism; Paracrine Communication; Tissue Engineering; Paracrine effects; Mesenchymal stem cells (MSCs); Mechanism

Mesenchymal stem cells (MSCs) are one of a few stem cell types to be applied in clinical practice as therapeutic agents for immunomodulation and ischemic tissue repair. In addition to their multipotent differentiation potential, a strong paracrine capacity has been proposed as the principal mechanis...