Effect of Corticosterone and Cortisol on Corticosteroidogenesis in Isolated Rat Adrenal Cells

Isolated rat adrenal cells were incubated with corticosterone or cortisol in the presence of ACTH. When the corticosterone production in the absence of exogenous corticoids was taken as 100%, it was decreased to 77±3 and 62±4% by the addition of 1.0 and 2.0 μg of corticosterone to 1ml of incubation...

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Bibliographic Details
Published inThe Tohoku Journal of Experimental Medicine Vol. 112; no. 2; pp. 195 - 196
Main Authors ABE, KIICHIRO, HIROSE, TAEKO
Format Journal Article
LanguageEnglish
Published Japan Tohoku University Medical Press 01.01.1974
Subjects
Adrenal Cortex Hormones - biosynthesis
Adrenal Glands - metabolism
Adrenocorticotropic Hormone - pharmacology
Animals
Corticosterone - pharmacology
Depression, Chemical
Feedback
Hydrocortisone - pharmacology
In Vitro Techniques
isolated rat adrenal cell
Male
negative feedback at the adrenal level
negative feedback on corticosteroidogenesis
Rats
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Summary:Isolated rat adrenal cells were incubated with corticosterone or cortisol in the presence of ACTH. When the corticosterone production in the absence of exogenous corticoids was taken as 100%, it was decreased to 77±3 and 62±4% by the addition of 1.0 and 2.0 μg of corticosterone to 1ml of incubation medium, respectively. However, the same concentration of cortisol did not show any inhibitory effect on corticosterone production.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0040-8727
1349-3329
DOI:10.1620/tjem.112.195