p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells
p53 and tau are both associated with neurodegenerative disorders. Here, we show by Western blotting that p53 is upregulated approximately 2-fold in the superior temporal gyrus of Alzheimer's patients compared to healthy elderly control subjects. Moreover, p53 was found to induce phosphorylation...
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| Published in | Neuroscience letters Vol. 418; no. 1; pp. 34 - 37 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Shannon
Elsevier Ireland Ltd
11.05.2007
Elsevier Elsevier Scientific Publishers Ireland |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0304-3940 1872-7972 |
| DOI | 10.1016/j.neulet.2007.03.026 |
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| Abstract | p53 and tau are both associated with neurodegenerative disorders. Here, we show by Western blotting that p53 is upregulated approximately 2-fold in the superior temporal gyrus of Alzheimer's patients compared to healthy elderly control subjects. Moreover, p53 was found to induce phosphorylation of human 2N4R tau at the tau-1/AT8 epitope in HEK293a cells. Confocal microscopy revealed that tau and p53 were spatially separated intracellularly. Tau was found in the cytoskeletal compartment, whilst p53 was located in the nucleus, indicating that the effects of p53 on tau phosphorylation are indirect. Collectively, these findings have ramifications for neuronal death associated with Alzheimer's disease and other tauopathies. |
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| AbstractList | p53 and tau are both associated with neurodegenerative disorders. Here, we show by Western blotting that p53 is upregulated approximately 2-fold in the superior temporal gyrus of Alzheimer's patients compared to healthy elderly control subjects. Moreover, p53 was found to induce phosphorylation of human 2N4R tau at the tau-1/AT8 epitope in HEK293a cells. Confocal microscopy revealed that tau and p53 were spatially separated intracellularly. Tau was found in the cytoskeletal compartment, whilst p53 was located in the nucleus, indicating that the effects of p53 on tau phosphorylation are indirect. Collectively, these findings have ramifications for neuronal death associated with Alzheimer's disease and other tauopathies. p53 and tau are both associated with neurodegenerative disorders. Here, we show by Western blotting that p53 is upregulated approximately 2-fold in the superior temporal gyrus of Alzheimer's patients compared to healthy elderly control subjects. Moreover, p53 was found to induce phosphorylation of human 2N4R tau at the tau-1/AT8 epitope in HEK293a cells. Confocal microscopy revealed that tau and p53 were spatially separated intracellularly. Tau was found in the cytoskeletal compartment, whilst p53 was located in the nucleus, indicating that the effects of p53 on tau phosphorylation are indirect. Collectively, these findings have ramifications for neuronal death associated with Alzheimer's disease and other tauopathies.p53 and tau are both associated with neurodegenerative disorders. Here, we show by Western blotting that p53 is upregulated approximately 2-fold in the superior temporal gyrus of Alzheimer's patients compared to healthy elderly control subjects. Moreover, p53 was found to induce phosphorylation of human 2N4R tau at the tau-1/AT8 epitope in HEK293a cells. Confocal microscopy revealed that tau and p53 were spatially separated intracellularly. Tau was found in the cytoskeletal compartment, whilst p53 was located in the nucleus, indicating that the effects of p53 on tau phosphorylation are indirect. Collectively, these findings have ramifications for neuronal death associated with Alzheimer's disease and other tauopathies. |
| Author | Hooper, Claudie Meimaridou, Eirini Melino, Gerry Killick, Richard Tavassoli, Mahvash Lovestone, Simon |
| AuthorAffiliation | b Cancer Gene Therapy Group, King's College London, The Rayne Institute, 123 Coldharbour Lane, London SE5 9NU, UK a King's College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK c Biochemistry Lab, Instituto Dermopatico Immacolata, c/o Department of Experimental Medicine, University of Roma Tor Vergata, Italy d Medical Research Council, Toxicology Unit, Leicester, UK |
| AuthorAffiliation_xml | – name: a King's College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK – name: c Biochemistry Lab, Instituto Dermopatico Immacolata, c/o Department of Experimental Medicine, University of Roma Tor Vergata, Italy – name: b Cancer Gene Therapy Group, King's College London, The Rayne Institute, 123 Coldharbour Lane, London SE5 9NU, UK – name: d Medical Research Council, Toxicology Unit, Leicester, UK |
| Author_xml | – sequence: 1 givenname: Claudie surname: Hooper fullname: Hooper, Claudie organization: King's College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK – sequence: 2 givenname: Eirini surname: Meimaridou fullname: Meimaridou, Eirini organization: King's College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK – sequence: 3 givenname: Mahvash surname: Tavassoli fullname: Tavassoli, Mahvash organization: Cancer Gene Therapy Group, King's College London, The Rayne Institute, 123 Coldharbour Lane, London SE5 9NU, UK – sequence: 4 givenname: Gerry surname: Melino fullname: Melino, Gerry organization: Biochemistry Lab, Instituto Dermopatico Immacolata, c/o Department of Experimental Medicine, University of Roma Tor Vergata, Italy – sequence: 5 givenname: Simon surname: Lovestone fullname: Lovestone, Simon organization: King's College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK – sequence: 6 givenname: Richard surname: Killick fullname: Killick, Richard email: r.killick@iop.kcl.ac.uk organization: King's College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK |
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| Keywords | Tau Alzheimer's disease Microtubules p53 Nervous system diseases Phosphorylation Alzheimer disease p53 Protein Cerebral disorder Tau protein Central nervous system disease Cytoskeleton Degenerative disease Microtubule |
| Language | English |
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| Snippet | p53 and tau are both associated with neurodegenerative disorders. Here, we show by Western blotting that p53 is upregulated approximately 2-fold in the... |
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| SubjectTerms | Aged Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Biological and medical sciences Blotting, Western Cell Line, Tumor Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Humans Medical sciences Microscopy, Confocal Microtubules Neurology p53 Phosphorylation Tau tau Proteins - metabolism Temporal Lobe - metabolism Temporal Lobe - pathology Tumor Suppressor Protein p53 - metabolism Vertebrates: nervous system and sense organs |
| Title | p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells |
| URI | https://dx.doi.org/10.1016/j.neulet.2007.03.026 https://www.ncbi.nlm.nih.gov/pubmed/17399897 https://www.proquest.com/docview/70416532 https://pubmed.ncbi.nlm.nih.gov/PMC1885960 |
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