A Randomized Trial Comparing Skin Antiseptic Agents at Cesarean Delivery

• Published in: The New England journal of medicine Vol. 374; no. 7; pp. 647 - 55
• Main Authors: Tuuli, Methodius G, Liu, Jingxia, Stout, Molly J, Martin, Shannon, Cahill, Alison G, Odibo, Anthony O, Colditz, Graham A, Macones, George A
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 18.02.2016
• Subjects: Adult; Anti-Infective Agents, Local - adverse effects; Anti-Infective Agents, Local - therapeutic use; Antimicrobial agents; Antisepsis - methods; Cesarean Section; Chlorhexidine; Chlorhexidine - adverse effects; Chlorhexidine - therapeutic use; Clinical trials; Evidence-based medicine; Female; Humans; Infections; Iodine; Iodine - adverse effects; Iodine - therapeutic use; Motivation; Pathogens; Pregnancy; Prevention; Skin; Skin - drug effects; Surgical site infections; Surgical Wound Infection - prevention & control

In this single-center trial comparing chlorhexidine–alcohol with iodine–alcohol for skin antisepsis before cesarean delivery, the use of chlorhexidine–alcohol resulted in a risk of surgical-site infection that was significantly lower than that associated with iodine–alcohol. Cesarean delivery is the...