Shock wave treatment induces angiogenesis and mobilizes endogenous CD31/CD34-positive endothelial cells in a hindlimb ischemia model: Implications for angiogenesis and vasculogenesis

• Published in: The Journal of thoracic and cardiovascular surgery Vol. 146; no. 4; pp. 971 - 978
• Main Authors: Tepeköylü, Can, Wang, Feng-Sheng, Kozaryn, Radoslaw, Albrecht-Schgoer, Karin, Theurl, Markus, Schaden, Wolfgang, Ke, Huei-Jin, Yang, Yaju, Kirchmair, Rudolf, Grimm, Michael, Wang, Ching-Jen, Holfeld, Johannes
• Format: Journal Article
• Language: English
• Published: United States Mosby, Inc 01.10.2013
• Subjects: Animals; Antigens, CD34 - metabolism; Biomarkers - metabolism; Cardiothoracic Surgery; Cell Movement; Chemokine CXCL12 - genetics; Chemokine CXCL12 - metabolism; Disease Models, Animal; Endothelial Cells - metabolism; High-Energy Shock Waves - therapeutic use; Hindlimb; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Ischemia - genetics; Ischemia - metabolism; Ischemia - physiopathology; Ischemia - therapy; Muscle, Skeletal - blood supply; Neovascularization, Physiologic; Platelet Endothelial Cell Adhesion Molecule-1 - metabolism; Rats; Rats, Sprague-Dawley; Receptors, CXCR4 - genetics; Receptors, CXCR4 - metabolism; Recovery of Function; Regional Blood Flow; Time Factors; Vascular Endothelial Growth Factor A - genetics; Vascular Endothelial Growth Factor A - metabolism; CTR; Ct; SWT; 39.2; PCNA; 39.4; VEGF; SDF-1; EPC; HIF-1α; hypoxia-inducible factor 1α; shock wave therapy; cycle threshold; endothelial progenitor cell; control; proliferating cell nuclear antigen; vascular endothelial growth factor; stromal cell-derived factor-1

Shock waves have been shown to induce recruitment of intravenously injected endothelial progenitor cells to ischemic hind limbs in rats. We hypothesized that shock wave treatment as sole therapy would induce angiogenesis in this ischemia model and would lead to mobilization of endogenous endothelial...