Efficacy of trabectedin (ecteinascidin-743) in advanced pretreated myxoid liposarcomas: a retrospective study

• Published in: The lancet oncology Vol. 8; no. 7; pp. 595 - 602
• Main Authors: Grosso, Federica, Dr, Jones, Robin L, MD, Demetri, George D, MD, Judson, Ian R, Prof, Blay, Jean-Yves, Prof, Le Cesne, Axel, MD, Sanfilippo, Roberta, MD, Casieri, Paola, PhD, Collini, Paola, MD, Dileo, Palma, MD, Spreafico, Carlo, MD, Stacchiotti, Silvia, MD, Tamborini, Elena, PhD, Tercero, Juan Carlos, PhD, Jimeno, Josè, MD, D'Incalci, Maurizio, MD, Gronchi, Alessandro, MD, Fletcher, Jonathan A, PhD, Pilotti, Silvana, MD, Casali, Paolo G, MD
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2007; Elsevier Limited
• Subjects: Adult; Antineoplastic Agents, Alkylating - therapeutic use; Chemotherapy; Dioxoles - therapeutic use; Disease-Free Survival; Female; Hematology, Oncology and Palliative Medicine; Humans; Liposarcoma; Liposarcoma, Myxoid - drug therapy; Liposarcoma, Myxoid - pathology; Magnetic Resonance Imaging; Male; Medical prognosis; Metastasis; Middle Aged; Oncogene Proteins, Fusion - genetics; Oncogene Proteins, Fusion - metabolism; Patients; Response rates; Retrospective Studies; Sarcoma; Tetrahydroisoquinolines - therapeutic use; Tomography, X-Ray Computed; United States > US

Summary Background Previous studies have suggested that trabectedin (ecteinascidin-743) could have antitumour activity in soft-tissue sarcoma. We aimed to study the usefulness of trabectedin in the treatment of patients with myxoid liposarcomas, a subtype of liposarcoma that is associated with speci...