Downregulation of PRMT1 promotes the senescence and migration of a non-MYCN amplified neuroblastoma SK-N-SH cells

• Published in: Scientific reports Vol. 9; no. 1; p. 1771
• Main Authors: Lee, Yu-Jen, Chang, Wen-Wei, Chang, Chien-Ping, Liu, Tsung-Yun, Chuang, Chun-Yi, Qian, Kun, Zheng, Y. George, Li, Chuan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.02.2019; Nature Publishing Group
• Subjects: 13; 14; 14/1; 38; 38/1; 38/77; 631/80/458/1648; 631/80/509; Arginine; Cancer; Cell cycle; DNA damage; Growth rate; Humanities and Social Sciences; Metastases; multidisciplinary; Neuroblastoma; p53 Protein; Phenotypes; Protein arginine methyltransferase; Science; Science (multidisciplinary); Senescence

Protein arginine methyltransferase 1 (PRMT1) catalyzing the formation of asymmetric dimethylarginines has been implicated in cancer development, metastasis, and prognosis. In this study, we investigated the effects of low PRMT1 levels on a non- MYCN amplified neuroblastoma SK-N-SH cell line. Stable...