Differential redox regulation of ORAI ion channels: a mechanism to tune cellular calcium signaling

• Published in: Science signaling Vol. 3; no. 115; p. ra24
• Main Authors: Bogeski, Ivan, Kummerow, Carsten, Al-Ansary, Dalia, Schwarz, Eva C, Koehler, Richard, Kozai, Daisuke, Takahashi, Nobuaki, Peinelt, Christine, Griesemer, Desiree, Bozem, Monika, Mori, Yasuo, Hoth, Markus, Niemeyer, Barbara A
• Format: Journal Article
• Language: English
• Published: United States 30.03.2010
• Subjects: Calcium Channels - metabolism; Calcium Signaling; Cell Differentiation; Cell Proliferation; Cell Survival; Humans; Hydrogen Peroxide - chemistry; Hydrogen Peroxide - metabolism; Interleukin-2 - metabolism; Jurkat Cells; ORAI1 Protein; Oxidation-Reduction; Patch-Clamp Techniques; Protein Isoforms; Reactive Oxygen Species; RNA, Small Interfering - metabolism; T-Lymphocytes - metabolism

Reactive oxygen species (ROS) are involved in many physiological and pathophysiological cellular processes. We used lymphocytes, which are exposed to highly oxidizing environments during inflammation, to study the influence of ROS on cellular function. Calcium ion (Ca(2+)) influx through Ca(2+) rele...