SWI/SNF complex-deficient soft tissue neoplasms: An update

• Published in: Seminars in diagnostic pathology Vol. 38; no. 3; pp. 222 - 231
• Main Authors: Schaefer, Inga-Marie, Hornick, Jason L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2021
• Subjects: BAF; Mesenchymal; Sarcoma; SMARCA2; SMARCA4; SMARCB1; Soft tissue; SWI/SNF complex; SMARCB1; Sarcoma; SWI/SNF complex; BAF; Soft tissue; SMARCA2; Mesenchymal; SMARCA4

•Mutations of the SWI/SNF chromatin remodeling complex are found in >20% of cancers.•SMARCB1 is most frequently inactivated in SWI/SNF-deficient soft tissue neoplasms.•SMARCA4-deficient thoracic sarcomas are characterized by SMARCA4 and SMARCA2 loss.•Most SWI-SNF-deficient soft tissue neoplasms s...