The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 42; no. 3; pp. 598 - 605
• Main Authors: Polimanti, Renato, Wang, Qian, Meda, Shashwath A, Patel, Krishna T, Pearlson, Godfrey D, Zhao, Hongyu, Farrer, Lindsay A, Kranzler, Henry R, Gelernter, Joel
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.02.2017
• Subjects: Adult; Alcohol use; Alcoholism; Alcoholism - genetics; Amygdala - diagnostic imaging; Female; Genetics; Genome-Wide Association Study; Genomes; Gyrus Cinguli - diagnostic imaging; Humans; Inorganic Pyrophosphatase - genetics; Male; Medical imaging; Medicine; Middle Aged; Monetary incentives; Neuroimaging; Neurosciences; Original; Prefrontal Cortex - diagnostic imaging; Psychiatry; Public health; Risk-Taking; Sexual behavior; Sexual Behavior - physiology; Sexually transmitted diseases; STD; United States > US

To identify genetic mechanisms involved in the interplay of risky sexual behaviors (RSBs) and alcohol dependence (AD), we conducted genome-wide gene-by-AD (GW-GxAD) analyses of RSB in 3924 alcohol-exposed and sexually experienced subjects. RSBs were defined as a score based on lifetime experiences o...