The Prognostic Model Established by the Differential Expression Genes Based on CD8+ T Cells to Evaluate the Prognosis and the Response to Immunotherapy in Osteosarcoma

• Published in: Mediators of inflammation Vol. 2023; pp. 6563609 - 11
• Main Authors: Chen, Yu, Yan, Wei, Wang, Hongqing, Ou, Zhiliang, Chen, Huihong, Huang, Zhenhua, Yang, Jinlian, Liu, Biqiong, Ou, Fanjie, Zhang, Huang
• Format: Journal Article
• Language: English
• Published: United States Hindawi 09.02.2023; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Analysis; Bone cancer; Bone Neoplasms; Brain cancer; CD8 antigen; CD8-Positive T-Lymphocytes; Cells; Cluster analysis; Datasets; Genes; Humans; Immune checkpoint inhibitors; Immunotherapy; Lymphocytes; Lymphocytes T; Medical prognosis; Monoclonal antibodies; Osteosarcoma; Prognosis; Risk factors; RNA sequencing; Sarcoma; T cells; Tumors; China; Taiwan

Osteosarcoma (OS) is a malignant tumor with an extremely poor prognosis, especially in progressive patients. Immunotherapy based on immune checkpoint inhibitors (ICIs) is considered to be a promising treatment option for OS. Due to tumor heterogeneity, only a minority of patients benefit from immuno...