Relationship of Omega-3 fatty acids DHA and EPA with the inflammatory biomarker hs-CRP in children with sickle cell anemia

• Published in: Prostaglandins, leukotrienes and essential fatty acids Vol. 146; pp. 11 - 18
• Main Authors: Setty, B N Yamaja, Betal, Suhita Gayen, Miller, Robin E, Brown, Dawn S, Meier, Maureen, Cahill, Michele, Lerner, Norma B, Apollonsky, Nataly, Stuart, Marie J
• Format: Journal Article
• Language: English
• Published: Scotland Elsevier Ltd 01.07.2019
• Subjects: Adolescent; Anemia, Sickle Cell - blood; Anemia, Sickle Cell - diagnosis; Arachidonic Acid - blood; Biomarkers - blood; C-reactive protein; C-Reactive Protein - metabolism; Child; Child, Preschool; Docosahexaenoic acid; Docosahexaenoic Acids - blood; Eicosapentaenoic Acid - blood; Erythrocytes - metabolism; Fatty Acids, Omega-3 - blood; Humans; Inflammation - blood; Inflammatory biomarkers; Omega-3 fatty acids; Phosphatidylcholines - blood; Phosphatidylethanolamines - blood; Polyunsaturated fatty acids; Risk Factors; Sickle cell anemia; Inflammatory biomarkers; Sickle cell anemia; C-reactive protein; Docosahexaenoic acid; Polyunsaturated fatty acids; Omega-3 fatty acids

•Chronic inflammation is one of the hallmarks of sickle cell disease (SCD). We have previously demonstrated that the inflammatory biomarker hs-CRP positively correlated with vaso-occlusive pain in SCD.•In children with SCD, ratios of pro-inflammatory arachidonic acid (AA) to anti-inflammatory docosa...