Role of a Lateral Orbital Frontal Cortex-Basolateral Amygdala Circuit in Cue-Induced Cocaine-Seeking Behavior

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 42; no. 3; pp. 727 - 735
• Main Authors: Arguello, Amy A, Richardson, Ben D, Hall, Jacob L, Wang, Rong, Hodges, Matthew A, Mitchell, Marshall P, Stuber, Garret D, Rossi, David J, Fuchs, Rita A
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.02.2017
• Subjects: Abstinence; Addictions; Adeno-associated virus; Animals; Basolateral Nuclear Complex - physiopathology; Behavior, Animal - physiology; Brain; Cocaine; Cocaine - pharmacology; Cocaine-Related Disorders - physiopathology; Cues; Disease Models, Animal; Dopamine Uptake Inhibitors - pharmacology; Drug-Seeking Behavior; Experiments; Laboratory animals; Male; Neurosciences; Optogenetics; Original; Physiology; Prefrontal Cortex - physiopathology; Rats; Rats, Sprague-Dawley; Veterinary colleges; Veterinary medicine; United States > US

Cocaine addiction is a disease characterized by chronic relapse despite long periods of abstinence. The lateral orbitofrontal cortex (lOFC) and basolateral amygdala (BLA) promote cocaine-seeking behavior in response to drug-associated conditioned stimuli (CS) and share dense reciprocal connections....