Role of H3K27 methylation in the regulation of lncRNA expression

• Published in: Cell research Vol. 20; no. 10; pp. 1109 - 1116
• Main Authors: Wu, Susan C, Kallin, Eric M, Zhang, Yi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2010; Nature Publishing Group
• Subjects: 631/208/176; 631/208/191/2018; 631/337/384/2568; Animals; Biomedical and Life Sciences; Cell Biology; DNA Methylation; Embryonic Stem Cells - metabolism; Enhancer of Zeste Homolog 2 Protein; Gene Silencing; Histone-Lysine N-Methyltransferase - genetics; Histone-Lysine N-Methyltransferase - metabolism; Histone-Lysine N-Methyltransferase - physiology; Histones - genetics; Histones - metabolism; Histones - physiology; Life Sciences; Methylation; Mice; Microarray Analysis; original-article; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Promoter Regions, Genetic; Repressor Proteins - metabolism; RNA, Untranslated - metabolism; histone methylation; Polycomb repressive complex 2; lncRNA

Once thought to be transcriptional noise, large non-coding RNAs (lncRNAs) have recently been demonstrated to be functional molecules. The cell-type-specific expression patterns of lncRNAs suggest that their transcription may be regulated epigenetically. Using a custom-designed microarray, here we ex...