Nutrient control of insulin secretion in perifused adult pig islets

• Published in: Diabetes & metabolism Vol. 33; no. 6; pp. 430 - 438
• Main Authors: Dufrane, D, Nenquin, M, Henquin, J.C
• Format: Journal Article
• Language: English
• Published: Paris Elsevier Masson SAS 01.12.2007; Masson
• Subjects: Amino Acids - pharmacology; Animals; Associated diseases and complications; Biological and medical sciences; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinology & Metabolism; Endocrinopathies; Glucose - pharmacology; Human islets; Insulin - metabolism; Insulin Secretion; Internal Medicine; Islets of Langerhans - drug effects; Islets of Langerhans - metabolism; Isolated islets; Kinetics; Medical sciences; Perfusion; Pig islets; Swine; Sécrétion d'insuline; Transplantation; Îlots humains; Îlots isolés; Îlots porcins; Îlots porcins; Sécrétion d'insuline; Human islets; Transplantation; Isolated islets; Pig islets; Îlots isolés; Insulin secretion; Îlots humains; Endocrinopathy; Pancreatic hormone; Secretion; Diabetes mellitus; Langerhans islet; Heterograft; Insulin; Pig; Vertebrata; Mammalia; Treatment; Animal; Nutrient; Artiodactyla; Ungulata; Endocrine pancreas

Abstract Objectives Xenotransplantation of pig islets is a potential solution to the shortage of human islets, but our knowledge of how these islets secrete insulin in response to nutrients is still fragmentary. This was the question addressed in the present study. Methods After 24 h culture adult p...