Molecular dynamic simulation insights into the normal state and restoration of p53 function

• Published in: International journal of molecular sciences Vol. 13; no. 8; pp. 9709 - 9740
• Main Authors: Fu, Ting, Min, Hanyi, Xu, Yong, Chen, Jianzhong, Li, Guohui
• Format: Journal Article Book Review
• Language: English
• Published: Switzerland MDPI AG 01.08.2012; Molecular Diversity Preservation International (MDPI)
• Subjects: Animals; conformational change; Drug Design; Humans; MDM2; MDMX; Models, Molecular; molecular dynamic simulation; Molecular Dynamics Simulation; p53; Protein Conformation; protein-ligand interaction; protein-protein interaction; Review; Tumor Suppressor Protein p53 - chemistry; Tumor Suppressor Protein p53 - metabolism; MDMX; protein-ligand interaction; MDM2; protein-protein interaction; conformational change; molecular dynamic simulation; p53

As a tumor suppressor protein, p53 plays a crucial role in the cell cycle and in cancer prevention. Almost 50 percent of all human malignant tumors are closely related to a deletion or mutation in p53. The activity of p53 is inhibited by over-active celluar antagonists, especially by the over-expres...