1D network simulations for evaluating regional flow and pressure distributions in healthy and asthmatic human lungs

• Published in: Journal of applied physiology (1985) Vol. 127; no. 1; pp. 122 - 133
• Main Authors: Choi, Sanghun, Yoon, Sujin, Jeon, Jichan, Zou, Chunrui, Choi, Jiwoong, Tawhai, Merryn H., Hoffman, Eric A., Delvadia, Renishkumar, Babiskin, Andrew, Walenga, Ross, Lin, Ching-Long
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.07.2019
• Subjects: Aerodynamics; Asthma; Boundary conditions; Computational fluid dynamics; Computed tomography; Computer applications; Computer simulation; Constrictions; Dilation; Energy balance; Flow distribution; Flow resistance; Fluid dynamics; Hydrodynamics; Hysteresis; Hysteresis models; Lungs; Mathematical models; Pressure; Pressure distribution; Pressure drop; Regional analysis; Respiratory tract; Simulation; Stress concentration; Workload; boundary condition; lung compliance; airway diameter; airway resistance; lung hysteresis

This study aimed to introduce a one-dimensional (1D) computational fluid dynamics (CFD) model for airway resistance and lung compliance to examine the relationship between airway resistance, pressure, and regional flow distribution. We employed five healthy and five asthmatic subjects who had dynami...